Evolution of the serum amyloid A (SAA) protein superfamily

The serum amyloid A (SAA) superfamily comprises a number of genes and proteins characterized from a range of mammalian species. The majority of members described to date are dramatically induced during the acute-phase response, suggesting an important short-term beneficial role in the response to tissue injury and inflammation. However, important disease associations have also been proposed for certain SAAs during chronic inflammation. The nomenclature of many of the superfamily members has been the result of comparisons with previously reported sequences implying disease association and/or functional relatedness between such members. The evolutionary relationships of the SAA superfamily members have been investigated by comparisons at both the amino acid and the nucleotide level. The results indicate that all members of the superfamily within a species have been undergoing concerted evolution. This has important implications in ascribing functions and disease associations to individual SAA superfamily members and indicates that designations should not be based on the extent of amino acid identity alone but should be made only following direct experimental observation of the proteins themselves.     

Self-defeating personality, depression, and pleasure from activities

Prior research has shown people who scored high on a measure of self-defeating personality experienced less pleasure from various activities and accomplishments. The present research replicated the initial study with 55 men and 60 women, while controlling for the effects of depression. Analyses indicated that, while depression and self-defeating personality were related, depression was not the entire answer for why people with self-defeating personality derive less pleasure from activities.     

Soldering a 3D Wire Lattice Structure

Soldering the junctions in a novel woven structure constructed from metallic wires is expected to significantly enhance the mechanical properties of that structure. The ideal bond geometry has solder localized at wire junctions and a uniform amount of solder at each junction throughout the structure. By examining the effects of solvent variations, liquid flux concentration, and solder powder concentration on the soldered joint geometry and distribution, we have developed a new procedure to bond these wire junctions using a very fine solder powder suspended in a flux solution.     

The Relation Between Television Exposure and Theory of Mind Among Preschoolers

This study explored the relation between preschoolers' television exposure and one important indicator of cognitive processing called theory of mind (ToM). A total of 107 preschoolers and their parents provided data on the preschoolers' television exposure (including both intentional viewing and exposure via background television), parent–child discussion of television, and preschoolers' ToM. The results indicated that preschoolers who were exposed to more background television and who had a television in their bedroom performed more poorly on ToM assessments compared with other children. Parent–child discussion of television was positively related to ToM performance, however. These results have implications for how we understand the effects of television on preschoolers.     

Evaluation of the degree of cure of a coating

Coating cure is compared using pencil hardness, MEK rubs, and thumb twist test to evaporation rate analysis (ERA). ERA is rated most objective and reproducible. Department of Polymer Science, Hattiesburg, MS. Rockville, MD.     

A randomized double‐blind crossover study of indoor air filtration and acute changes in cardiorespiratory health in a First Nations community

Few studies have examined indoor air quality in First Nations communities and its impact on cardiorespiratory health. To address this need, we conducted a crossover study on a First Nations reserve in Manitoba, Canada, including 37 residents in 20 homes. Each home received an electrostatic air filter and a placebo filter for 1 week in random order, and lung function, blood pressure, and endothelial function measures were collected at the beginning and end of each week. Indoor air pollutants were monitored throughout the study period. Indoor PM_2.5 decreased substantially during air filter weeks relative to placebo (mean difference: 37 μg/m³, 95% CI: 10, 64) but remained approximately five times greater than outdoor concentrations owing to a high prevalence of indoor smoking. On average, air filter use was associated with a 217‐ml (95% CI: 23, 410) increase in forced expiratory volume in 1 s, a 7.9‐mm Hg (95% CI: ?17, 0.82) decrease in systolic blood pressure, and a 4.5‐mm Hg (95% CI: ?11, 2.4) decrease in diastolic blood pressure. Consistent inverse associations were also observed between indoor PM_2.5 and lung function. In general, our findings suggest that reducing indoor PM_2.5 may contribute to improved lung function in First Nations communities.     

‘Day Labour’ and ‘Xenophobia’ in South Africa: the Need for Mixed Methods Approaches in Policy-Orientated Research

Much policy-orientated research in South Africa relies solely on large-scale surveys. Little or no case study research is undertaken as part of studies despite broad international acknowledgement of the benefits of mixing methods. In the South African poverty and demographic literature, strong arguments have been made for the incorporation of case study approaches to arrive at a deeper and more accurate understanding of social phenomena. This paper, which draws on an ethnographic study of ‘day labourers’ (both South African and foreign) in Cape Town, together with an extensive range of relevant literature, extends this line of argument to research on casual employment and relations between South Africans and foreign nationals. It highlights a number of questionable assumptions and superficial analyses present in previous survey-based research on these topics. It also discusses the potential contribution of more case study work and some of the practical issues associated with linking methodologies in development research.     

Comparison of coagulation performance and floc properties using a novel zirconium coagulant against traditional ferric and alum coagulants

Coagulation in drinking water treatment has relied upon iron (Fe) and aluminium (Al) salts throughout the last century to provide the bulk removal of contaminants from source waters containing natural organic matter (NOM). However, there is now a need for improved treatment of these waters as their quality deteriorates and water quality standards become more difficult to achieve. Alternative coagulant chemicals offer a simple and inexpensive way of doing this. In this work a novel zirconium (Zr) coagulant was compared against traditional Fe and Al coagulants. The Zr coagulant was able to provide between 46 and 150% lower dissolved organic carbon (DOC) residual in comparison to the best traditional coagulant (Fe). In addition floc properties were significantly improved with larger and stronger flocs forming when the Zr coagulant was used with the median floc sizes being 930 μm for Zr; 710 μm for Fe and 450 μm for Al. In pilot scale experiments, a similar improved NOM and particle removal was observed. The results show that when optimised for combined DOC removal and low residual turbidity, the Zr coagulant out-performed the other coagulants tested at both bench and pilot scale.