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排序方式: 共有989条查询结果,搜索用时 15 毫秒
121.
Dr. Ezgi Ozyerli-Goknar Dr. Sheikh Nizamuddin Prof. Dr. H. T. Marc Timmers 《ChemMedChem》2021,16(9):1391-1402
Targeting protein-protein interactions (PPIs) with small-molecule inhibitors has become a hotbed of modern drug development. In this review, we describe a new class of PPI inhibitors that block menin from binding to MLL proteins. Menin is encoded by the MEN1 tumor suppressor, but acts as an essential cofactor for MLL/KMT2A-rearranged leukemias. The most promising menin-MLL inhibitors belong to the thienopyrimidine class and have recently entered phase I/II clinical trials for treating acute leukemias characterized by MLL/KMT2A translocations or NPM1 mutations. As single agents, thienopyrimidine compounds eradicate leukemia in a xenograft models of primary leukemic cells belonging to the MLL-rearranged or NPM1-mutant subtypes. These compounds are well tolerated with few or no side effects, which is remarkable given the tumor-suppressor function of menin. The menin-MLL inhibitors highlight how leukemia patients could benefit from a targeted epigenetic therapy with novel PPI inhibitors obtained by directed chemical evolution. 相似文献
122.
Hurrah Nasir N. Parah Shabir A. Sheikh Javaid A. 《Multimedia Tools and Applications》2020,79(29-30):21441-21470
Multimedia Tools and Applications - In e-healthcare applications integrity of the received information is of prime importance for ensuring the accurate diagnosis. The integrity of electronic... 相似文献
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124.
Over the last decade, dendritic structures including hyperbranched polymers, dendrigrafts, dendrons, and dendrimers due to their distinct structural design such as highly branched structure and a large number of reactive end groups have received considerable attention. Among various kind of dendrimer, particularly amine-terminated dendritic materials like polyamidoamine (PAMAM), polypropylene imine (PPI), and polyethylene imine (PEI) have been introduced as the potential candidates in a wide range of areas, particularly in the field of textiles engineering. Hence, this review provides an introduction of amine-terminated dendritic polymers and new potential applications of them in textiles engineering such as improvement of dyeability, salt-free dyeability, antimicrobial activity, long-lasting fragrant fabric, anti-ultraviolet property, drug delivery through fabric, flame retardancy, and wastewater treatment. Regarding the complex synthesis of dendrimers which makes them expensive products, application of amine-terminated hyperbranched polymers provides affordable dendritic polymers to create novel features. 相似文献
125.
Bahador Akbari Asghar Lashanizadegan Parviz Darvishi Abdolrasoul Pouranfard 《中国化学工程学报》2020,28(6):1566-1581
In this study, poly(vinilydene fluoride-co-hexafluoropropylene)(PVDF-HFP) was used for preparation of hydrophobic membranes using non-solvent induced phase inversion(NIPS) technique. PVDF-HFP copolymer with concentrations of 10 wt% and 12 wt% was prepared to investigate the effect of polymer concentration on pore structure,morphology, hydrophobicity and performance of prepared membranes. Besides, the use of two coagulation baths with the effects of parameters such as coagulant time, polymer type and concentration, and the amount of nonsolvent were studied. The performance of prepared membranes was evaluated based on the permeability and selectivity of oxygen and nitrogen from a gas mixture of nitrogen/oxygen under operating conditions of feed flow rate(1–5 L·min~(-1)), inlet pressure to membrane module(0.1–0.5 MPa) and temperatures between 25 and 45 °C. The results showed that the use of two coagulation baths with different compositions of distillated water and isopropanol,coagulant time, polymer type and concentration, and the amount of non-solvent additive have the most effect on pore structure, morphology, thickness, roughness and crystallinity of fabricated membranes. Porosity ranges for the three fabricated membranes were determined, where the maximum porosity was 73.889% and the minimum value was 56.837%. Also, the maximum and minimum average thicknesses of membrane were 320.85 μm and115 μm. Besides, the values of 4.7504 × 10~(-7) mol· m~(-2)· s~(-1)· Pa~(-1), 0.525 and 902.126 nm were achieved for maximum oxygen permeance, O_2/N_2 selectivity and roughness, respectively. 相似文献
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127.
Muhammad Zafar Mushtaq Ahmad Shazia Sultana Lubna Adnan Amin Hafiz Muhammad Naseer Zafar Jamal Sheikh Zain Ul Abidin Sajid Mehmood Amir Shehzad Khan 《Microscopy research and technique》2019,82(5):550-557
The use of quality control tool for authentication of Jadwar (Delphinium denudatum Wall. ex Hook.f. & Thomson), a folk herbal drug used for the treatment of different ailments, was studied. People face problems of adulteration for this drug at global, regional, national and local levels. Two different plant species are commercially marketed in the Indo‐Pak Subcontinent under the same trade name of Jadwar. One is D. denudatum Wall. ex Hook.f. & Thomson and the other is Aconitum heterophyllum Wall. ex Royle. To focus on this problem, a marketable available drug sample of Jadwar was authenticated by using basic microscopy tools (LM) and advanced chemo‐taxonomic markers. Authentication, quality and standardization of this drug was achieved using morphology, organoleptography, UV and IR analyses, scanning electron microscopy of pollen and anatomical investigations. The techniques used for authentication marked the clear difference between the studied plants. Microscopic studies, chemotaxonomic investigation and other techniques used in this project provided the basis for the authentication of this species. 相似文献
128.
Ehsan Akbari Seyed Mehdi Alavi Mehran Rezaei Afsanehsadat Larimi 《International Journal of Hydrogen Energy》2021,46(7):5181-5196
In this study, a series of BaO-MnOx mixed oxide catalysts were synthesized by the mechanochemical method and employed in lean methane catalytic combustion (MCC) at low temperatures. The synthesized catalysts were characterized by XRD, BET, TGA, FT-IR, H2-TPR, O2-TPD, and FESEM analyses. The results indicated that the 10 wt% BaO-MnOx catalyst with a BET surface area of 25 m2 g?1 possessed the best catalytic performance. The higher activity of the 10 wt% BaO-MnOx catalyst was due to the higher ability to supply oxygen through the components during the MCC process. The light-off temperature corresponding to 50% of the methane conversion was about 330 °C, which was about 50 °C lower than the pure MnOx. Moreover, for the BaO(10)-MnOx catalyst, the 10 and 90% of methane conversion temperatures were about 305 and 427 °C, respectively. Also, the 10 wt% BaO-MnOx catalyst exhibited high catalytic stability under dry feed condition at 450 °C for 50 h. Furthermore, the influence of various parameters such as calcination temperature, feed ratio, GHSV, pretreatment condition, and presence of water vapor in the feedstock was studied on the catalytic performance. 相似文献
129.
Kalantary Samira Akbari Torkestani Javad Shahidinejad Ali 《The Journal of supercomputing》2021,77(12):13806-13827
The Journal of Supercomputing - Due to high and unpredictable connection delays, privacy gaps, and traffic load of networks connecting cloud computing to end users in many of the Internet of Things... 相似文献
130.
Wang Zhen Hu Zhenbiao Suo Tao Zhou Fenghua Li Yulong Muhammad Zakir Sheikh Wang Xiang Wang Yinmao 《Ceramics International》2018,44(10):11239-11256
Quasi-static and dynamic three-point-bending experiments were conducted on both annealed and chemically strengthened aluminosilicate glass scratched by different normal loads. Scratched areas were observed by optical microscope and atomic force microscope. Chemically strengthened glass shows better resistance to surface scratch. These dynamic experiments were carried out using a modified Split Hopkinson Pressure Bar (SHPB) device and a pulse-shaping technique was used to keep constant loading speed to the specimens. In tests, high-speed photography was also used to observe the failure process of the specimens. The test results showed that the flexural strength of aluminosilicate glass (AG) strongly depends on the applied loading speed. Compared with its annealed counterpart, the chemically strengthened glass (CSG) showed higher flexural strength to both static and dynamic loadings. Moreover, the three-point bending experiments were conducted on scratched AG and CSG specimens and decrease of 20–40% in flexural strength was observed. The fractography analysis showed that in dynamic loading conditions the fracture surface was not smooth and has more secondary cracks as compared to static loading. 相似文献