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排序方式: 共有304条查询结果,搜索用时 31 毫秒
81.
Koichiro Nakanishi Shigeto Fujita Hiroshi Kurita Akio Kishi Taketoshi Hasegawa Yoshikazu Shibuya 《Electrical Engineering in Japan》2000,132(4):45-52
Switching operations in gas insulated switchgear (GIS) can generate very fast transient overvoltages (VFTO) which propagate in the GIS with little attenuation. When a transformer is directly connected to the GIS through a gas/oil bushing, the VFTO can enter the transformer and excite the voltage oscillation in the windings. In the paper, we firstly show a resonance phenomenon due to the superposition of the traveling waves which was found in the experiments using the coil windings of a 500 kV transformer. The fundamental resonance frequency ranged at about 2 MHz, and its voltage at the interturn (turn‐to‐turn) of the coil could reach 0.25 times of the applied voltage in the worst case. Secondly, the electrical breakdown properties of interturn insulation in oil were studied, applying the unipolar and bipolar voltages with 2 MHz oscillatory frequency. The breakdown voltages at the unipolar and bipolar VFT oscillatory stresses were about 1.25 and 1.40 times higher than that at the standard lighting impulse, respectively. We discuss the experimental breakdown stresses with the ones estimated from the analysis of VFTO in the transformer windings and also show the methods to cope with the VFTO. © 2000 Scripta Technica, Electr Eng Jpn, 132(4): 45–52, 2000 相似文献
82.
Y Mori M Takayasu Y Suzuki M Shibuya J Yoshida H Hidaka 《Canadian Metallurgical Quarterly》1997,330(2-3):195-198
The effects of adrenomedullin on isolated rat intracerebral arterioles were investigated and compared with those of calcitonin gene-related peptide (CGRP) and amylin. Adrenomedullin produced dose-dependent vasodilation (maximum dilation 27.1 +/- 2.1% at 3 x 10(-7) M, median effective dose (EC50)) 1.6 x 10(-9) M). CGRP produced similar vasodilation (19.8 +/- 4.1%) at 10(-7) M with a lower EC50 of 2.8 x 10(-11) M. Amylin did not cause vasodilation at concentrations up to 10(-6) M. Adrenomedullin-induced vasodilation was significantly suppressed by CGRP-(8-37). These data suggest that adrenomedullin is a potent vasodilator for arterioles in the cerebral microcirculation that acts through CGRP receptors. 相似文献
83.
K Tanaka I Shibuya Y Uezono Y Ueta Y Toyohira N Yanagihara F Izumi T Kanno H Yamashita 《Canadian Metallurgical Quarterly》1998,70(4):1652-1661
Pituitary adenylate cyclase-activating polypeptide (PACAP) causes both Ca2+ release and Ca2+ influx in bovine adrenal chromaffin cells. To elucidate the mechanisms of PACAP-induced Ca2+ release, we investigated expression of PACAP receptors and measured inositol trisphosphates (IP3), cyclic AMP, and the intracellular Ca2+ concentration in bovine adrenal medullary cells maintained in primary culture. RT-PCR analysis revealed that bovine adrenal medullary cells express the PACAP receptor hop, which is known to couple with both IP3 and cyclic AMP pathways. The two naturally occurring forms of PACAP, PACAP38 and PACAP27, both increased cyclic AMP and IP3, and PACAP38 was more potent than PACAP27 in both effects. Despite the effects of PACAP on IP3 production, the Ca2+ release induced by PA-CAP38 or by PACAP27 was unaffected by cinnarizine, a blocker of IP3 channels. The potencies of the peptides to cause Ca2+ release in the presence of cinnarizine were similar. The Ca2+ release induced by PACAP38 or by PACAP27 was strongly inhibited by ryanodine and caffeine. In the presence of ryanodine and caffeine, PACAP38 was more potent than PACAP27. PACAP-induced Ca2+ release was unaffected by Rp-adenosine 3',5'-cyclic monophosphothioate, an inhibitor of protein kinase A. Ca2+ release induced by bradykinin and angiotensin II was also inhibited by ryanodine and caffeine, but unaffected by cinnarizine. Although IP3 production stimulated by PACAP38 or bradykinin was abolished by the phospholipase C inhibitor, U-73122, Ca2+ release in response to the peptides was unaffected by U-73122. These results suggest that PACAP induces Ca2+ release from ryanodine/caffeine stores through a novel intracellular mechanism independent of both IP3 and cyclic AMP and that the mechanism may be the common pathway through which peptides release Ca2+ in adrenal chromaffin cells. 相似文献
84.
In the accompanying paper (Luo et al., Cancer Res., 58: 2652-2660, 1998), we demonstrated that vascular endothelial growth factor (VEGF), also designated vascular permeability factor (VPF), significantly accumulated in all mouse malignant ascites tested, suggesting its fundamental role in ascites tumors. Removal of VEGF may inhibit the development of ascites tumors. In this study, using a goat antimouse VEGF-neutralizing antibody, we tested this hypothesis with two well-defined syngeneic mouse ascites tumors: MM2 breast adenocarcinoma and OG/Gardner lymphoma 6C3HED (expressing moderate and low levels of VEGF, respectively). This antibody significantly inhibited MM2 and OG cell-free ascites fluid-induced hyperpermeability of mouse peritoneal microvessels and in vitro endothelial cell growth. Mice bearing tumors were administered i.p. daily with the antibody or normal goat IgG as controls for 8 days, at doses of 20-fold (for MM2-bearing mice) or 40-fold (for OG-bearing mice) the estimated amounts of VEGF that kinetically accumulated in the ascites fluid after the tumor inoculation. The average volume of ascites fluid, number of tumor cells and leaked RBCs, and the peritoneal microvessel permeability in MM2-bearing mice that received the antibody treatment were significantly lower than those in the matched controls (P < 0.01). Unexpectedly, OG-bearing mice did not show satisfactory response to the anti-VEGF treatment. This discrepancy was not likely due to inadequate doses or different host immune responses, but it was quite possibly to the different characteristics of MM2 carcinoma and OG lymphoma tumors, the latter being strongly invasive, and/or the existence of an inflammatory mediator(s), such as bradykinin or cytokine(s) other than VEGF. In summary, our results directly demonstrated, for the first time, differential roles for VEGF in ascites tumors in vivo and suggest the potential of VEGF inhibition as a specific therapy for ascites tumors of carcinoma origin, which are the major cause of the malignant ascites in adult humans. 相似文献
85.
B Olofsson E Korpelainen MS Pepper SJ Mandriota K Aase V Kumar Y Gunji MM Jeltsch M Shibuya K Alitalo U Eriksson 《Canadian Metallurgical Quarterly》1998,95(20):11709-11714
The vascular endothelial growth factor (VEGF) family has recently expanded by the identification and cloning of three additional members, namely VEGF-B, VEGF-C, and VEGF-D. In this study we demonstrate that VEGF-B binds selectively to VEGF receptor-1/Flt-1. This binding can be blocked by excess VEGF, indicating that the interaction sites on the receptor are at least partially overlapping. Mutating the putative VEGF receptor-1/Flt-1 binding determinants Asp63, Asp64, and Glu67 to alanine residues in VEGF-B reduced the affinity to VEGF receptor-1 but did not abolish binding. Mutational analysis of conserved cysteines contributing to VEGF-B dimer formation suggest a structural conservation with VEGF and platelet-derived growth factor. Proteolytic processing of the 60-kDa VEGF-B186 dimer results in a 34-kDa dimer containing the receptor-binding epitopes. The binding of VEGF-B to its receptor on endothelial cells leads to increased expression and activity of urokinase type plasminogen activator and plasminogen activator inhibitor 1, suggesting a role for VEGF-B in the regulation of extracellular matrix degradation, cell adhesion, and migration. 相似文献
86.
JC Bitangcol AS Chau E Stadnick MJ Lohka B Dicken EK Shibuya 《Canadian Metallurgical Quarterly》1998,9(2):451-467
We have added constitutively active MAP kinase/ERK kinase (MEK), an activator of the mitogen-activated protein kinase (MAPK) signaling pathway, to cycling Xenopus egg extracts at various times during the cell cycle. p42MAPK activation during entry into M-phase arrested the cell cycle in metaphase, as has been shown previously. Unexpectedly, p42MAPK activation during interphase inhibited entry into M-phase. In these interphase-arrested extracts, H1 kinase activity remained low, Cdc2 was tyrosine phosphorylated, and nuclei continued to enlarge. The interphase arrest was overcome by recombinant cyclin B. In other experiments, p42MAPK activation by MEK or by Mos inhibited Cdc2 activation by cyclin B. PD098059, a specific inhibitor of MEK, blocked the effects of MEK(QP) and Mos. Mos-induced activation of p42MAPK did not inhibit DNA replication. These results indicate that, in addition to the established role of p42MAPK activation in M-phase arrest, the inappropriate activation of p42MAPK during interphase prevents normal entry into M-phase. 相似文献
87.
Inositol 1,4,5-trisphosphate (InsP3) is a key second messenger in many cell types and also in distinct subcellular regions of single living cells; however, little is examined about the subcellular dynamics of InsP3 in a variety of cell types. We have developed fluorescent indicators to locate InsP3 dynamics in single living cells based on an intramolecular fluorescence resonance energy transfer. Our indicator has visualized InsP3 dynamics in the cytoplasm of cultured cells and even in single thin dendrites of hippocampal neurons, which has been unseen previously. We have further localized the present indicator in the nucleus and pinpointed nuclear InsP3 dynamics. The observation with our nuclear InsP3 indicator has solved a question on nuclear propagation of InsP3 from the cytoplasm and has drawn a conclusion that the nuclear InsP3 dynamics synchronously occurs with cytosolic InsP3 dynamics evoked by agonist stimulations. The present approach contributes to the understanding of when, where, and how InsP3 is generated and removed in a variety of living cells. 相似文献
88.
Akira Onuki Yoshio Shibuya Shinichiro Kozaki 《Journal of Low Temperature Physics》1974,15(1-2):161-168
An exact solution of the parabolic partial differential equation with a moving boundary condition is found. Applications to the problem of ice formation are discussed. 相似文献
89.
Sato K Uematsu Y Isagawa S Tateba H Tomizawa M Oosaki K Hasebe A Shibuya S Nii H Higashinaka R Watanabe I Yamazaki T Tanamoto K Maitani T 《Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan》2004,45(6):302-306
Headspace GC using the standard addition method has been developed for the simultaneous determination of organic solvents in natural flavorings. The procedure can be outlined as follows: an aliquot of the sample is transferred to a 10 mL vial. To each vial, a DMSO solution containing solvents at different concentrations is added as the standard solution. The vials are kept at 50 degrees C (for automatic injection) or 40 degrees C (for hand-operated injection) for 40 minutes. One mL of the vapor phase in each vial is injected into a gas chromatograph equipped with an Aquatic-2 column (0.25 mm i.d. x 60 m). To evaluate this method, we conducted a performance study in collaboration with 10 laboratories, using ginger oleoresin. We analyzed 6 solvents (methanol, 2-propanol, acetone, dichloromethane, hexane, and 1,1,2-trichloroethene) for which the maximum residue limits are established in Japan's Specifications and Standards for Food Additives. Methanol and acetone existed in the ginger oleoresin, so only the other that four kinds of solvents were added to it. Eight of the laboratories used automatic injection, while the remaining two used hand-operated injection. Statistical analyses were conducted on the data obtained from the 8 laboratories. Repeatability standard deviations (RSDr) ranged from 4.3 to 11.4%, and reproducibility standard deviations (RSDR) ranged from 8.4 to 19.0%. 相似文献
90.
Jae Won Lee Zuhair A. Munir Masachika Shibuya Manshi Ohyanagi 《Journal of the American Ceramic Society》2001,84(6):1209-1216
The synthesis of dense nanometric composites of TiN-TiB2 by mechanical and field activation was investigated. Powder mixtures of Ti, BN, and B were mechanically activated through ball milling. Some powders were milled to reduce crystallite size but to avoid initiating a reaction. In other cases powders were milled and allowed to partially react. All these were subsequently reacted in a spark plasma synthesis (SPS) apparatus. The products were composites with equimolar nitride and boride components with relative densities ranging from 90.1% to 97.2%. Crystallite size analyses using the XRD treatments of Williamson-Hall and Halder-Wagner gave crystallite sizes for the TiN and TiB2 components in the range 38.5–62.5 and 31.2–58.8 nm, respectively. Vickers microhardness measurements (at 2 N force) on the dense samples gave values ranging from 14.8 to 21.8 GPa and fracture toughness determinations (at 20 N) resulted in values ranging from 3.32 to 6.50 MPa·m1/2 . 相似文献