Nonspecific effects of the pharmacological probes commonly used to analyze signal transduction in rabbit parietal cells

In order to examine some possibly misleading conclusions of the pharmacological analysis of the signal transduction pathways of gastric acid secretion, we evaluated various agents including inhibitors of protein kinase C, cyclic AMP-dependent protein kinase, phospholipase C, phospholipase A2, lipoxygenase, casein kinase, calmodulin, myosin light chain kinase, tyrosine kinase, anion exchanger, and protein phosphatase; and activators of protein kinase C. Among them, the cyclic AMP-dependent protein kinase inhibitor N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinylsulfonamide (H-89), the phospholipase A2 inhibitor 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (ONO-RS-082), three myosin light chain kinase inhibitors (1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-7), 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), and wortmannin), the anion exchanger inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), the phospholipase C inhibitor neomycin, and most known calmodulin antagonists strongly inhibited [14C]aminopyrine accumulation, an indicator of acid secretion, in isolated rabbit gastric glands stimulated by N6,2'-O-dibutyryl-cyclic AMP. ONO-RS-082, calmidazolium, and DIDS inhibited H+,K+-ATPase. Most of the chemicals with antisecretory activity showed protonophore-like activity in gastric microsomes as well as in the mitochondria. It is concluded that H-89, ONO-RS-082, ML-7, ML-9, neomycin, and all calmodulin antagonists tested so far should not be used as tools to analyze gastric acid secretion.     

Photoluminescence characteristics and pit formation of InGaN/GaN quantum-well structures grown on sapphire substrates by low-pressure metalorganic vapor phase epitaxy

We have examined how a growth interruption, caused by closing group-III sources, affects the crystalline quality of InGaN/GaN quantum-well (QW) structures grown by metalorganic vapor phase epitaxy. The QW samples were characterized by their photoluminescence (PL), and by atomic force microscopy (AFM), transmission electron microscopy (TEM), and energy dispersive x-ray (EDX) microanalysis. The PL peak wavelength was strongly dependent on the duration of the growth interruption and on the number of QW layers. AFM measurements revealed that the size of the open hexagonally shaped pits in the QW structures increased dramatically as the interruption duration was lengthened. Through TEM and EDX microanalysis, we found that the formation of these hexahedronal pits, formed due to the growth interruption, causes a large fluctuation in the In composition, especially around the pits, and the presence of such pits in an underlying QW layer strongly affects the In incorporation into the upper QW layers, leading to significant growth-rate variation in an InGaN QW layer and red-shifting of the PL spectra when a multiple-QW structure is grown.     

Direct observation of the interaction between vortices and dislocations in superconducting crystals by a cryo-Lorentz EM (interaction between vortices and dislocations)

Quantized magnetic flux lines (vortices) in a Nb foil were directly observed in different magnetic fields up to 200 G by a cryo-Lorentz electron microscope. The interaction of vortices with dislocations in the specimen was examined and clarified; edge-on dislocations weakly pin individual vortices at magnetic fields below 100 G. In higher magnetic fields the formation of a regular hexagonal vortex lattice started preferentially at in-plane dislocations. At 200 G the Abrikosov vortex lattice was formed with small domains, whose centre included the dislocations, showing their important role on the formation of the vortex lattice. For a NbTi foil no clear image of vortices could be seen, because the surface was rough due to the formation of fine grains and precipitates.     

Vapor-phase kinetics and its contribution to global three-phase reaction rate in hydrogenation of 1-methylnaphthalene

It has been considered that the contribution of the vapor-phase reaction (VPR) to the global three-phase reaction rate may become much lower as the catalyst effectiveness factor approaches unity. In this study, the hydrogenation of 1-methylnaphthalene was performed as an example of slow reactions using a laboratory-scale trickle-bed reactor (TBR) at 583 K, 8.0 MPa. It was qualitatively confirmed that VPR contributed to the product yields in TBR even in this slow reaction system when the liquid velocity was low and the volatility of the liquid was high. Langmuir–Hinshelwood type kinetic equations were established for the vapor-phase reaction. The product yields in TBR neither be explained by liquid- vapor-phase kinetics without external effects, nor the conventional partial wetting model. Therefore, a partial wetting model considering the contribution of VPR was proposed where the catalyst bed composed of externally partial and internally complete wet particles, and completely dry particles was assumed. Using this model, the product yields in TBR were suitably explained.     

Pore Structure and Thermal Stability of Mesoporous Mullite Fibers Prepared by Crystallization and Selective Leaching of Al2O3-SiO2 Glass Fibers

Porous mullite fibers were prepared by crystallization and selective leaching of Al2O3-SiO2 glass fibers using buffered HF-NH4F(BHF) aqueous solutions. The optimum concentration of BHF solution for selective leaching of the fibers was 0.9 mass% HF and 17.0 mass% NH4F. By firing at 1000–1300°C, the glass fibers changed into composite texture of mullite and glassy phase. Since the pores in the fibers were formed by selective leaching of glassy phase among mullite grains, they were tunable by changing the firing conditions of fibers. Pore size of the samples changed from around 4 nm in the 1100°C fired sample to 16 and 40 nm in the 1200 and 1300°C fired samples, respectively. The highest specific surface area obtained was around 30 m2/g, when the fibers were heat treated at 1200°C for 24 h and leached for 20 h in 0.9 mass% HF-17.0 mass% NH4F solution. From the thermal stability tests of the porous mullite fibers, its specific surface area was found to be maintained up to 1200–1300°C.     

Feasibility study of a feed-forwarding voltage-reactive power control method based on linear programming for a central control facility

Voltage–reactive power control (VVC) on power systems becomes difficult when a load increases or decreases rapidly, especially in the morning and at noon. This is caused mainly by two problems. One is delayed operation and the other is noncooperative operation of facilities. To solve these problems, an advanced method and algorithms for a centralized feed-forwarding control system are presented. They are based on two main steps: forecasting the power system state for several minutes and dispatching reactive power sources optimally based on stepwise linear programming. The proposed method is evaluated and tested for data of a large-scale power system. The results show that the proposed method keeps the voltage constraints well and reduces redundant operation of facilities. © 1998 Scripta Technica, Electr Eng Jpn, 125(1): 18–26, 1998     

Self-sizing network—algorithmic aspects

This paper presents a bandwidth adjustment mechanism for a self-sizing network, which has been proposed as an operation concept for ATM networks and is based on the autonomous adjustment of virtual path (VP) bandwidth. Several simple algorithms for estimating the bandwidth demand—the minimum bandwidth needed to satisfy the quality-of-service (QoS) objectives—are proposed for the case where QoS-guaranteed virtual channels (VCs) and best-effort VCs are multiplexed in separate VPs. The proposed algorithms use only a few assumptions about traffic characteristics, making them applicable to a wide range of traffic types. In addition, errors in VP bandwidth estimation are corrected by adaptively adjusting the VP bandwidth using real-time traffic measurement. Numerical examples confirm that the proposed algorithms can quickly restore the QoSs of VPs from any initial conditions and keep them at an appropriate level. © 1998 John Wiley & Sons, Ltd.     

A three-phase voltage-source neutral-point-clamped converter with divided capacitors

A new method for reducing harmonics involved in ac line currents of a three-phase voltage-source converter is proposed. It is applied to the conventional neutral-point-clamped inverter. By dividing a smoothing capacitor into four elements and adding four auxiliary switching devices, the input line-to-line voltages of the proposed converter can be made to have almost the same waveforms as a conventional 18-phase rectifier with 18 devices and three input transformers. In this paper, circuit performance and input voltage waveforms are discussed, and the optimum parameters are determined. Effects of harmonic reductions can be clarified by theoretical results. We suggest several output voltage adjustment methods. Characteristics of power factors and distortion factors in these methods are theoretically and experimentally investigated. © 1997 Scripta Technica, Inc. Electr Eng Jpn, 121(2): 72–82, 1997     

Optimization of heat sink geometries for impingement air-cooling of LSI packages

This paper describes the use of our previous study's prediction procedures for calculating thermal resistance and pressure drop. The procedures are used in the optimization of heat sink geometries for impingement air-cooling of LSI packages. Two types of heat sinks are considered: ones with longitudinal fins and ones with pin fins. We optimized the heat sink geometries by evaluating 16 parameters simultaneously. The parameters included fin thickness, spacing, and height. For the longitudinal fins, the optimal fin thicknesses were found to be between 0.12 and 0.15 mm, depending on which of the four types of fans were used. For pin fins, the optimal pin diameters were between 0.39 and 0.40 mm. Under constant pumping power, the optimal thermal resistance of the longitudinal fins was about 60% that of the pin fins. For both types of heat sinks, the optimal thermal resistance for four off-the-shelf fans was only slightly (maximum about 1%) higher than the theoretical optimum for the same pumping power. When manufacturing cost performance is considered, the most economical fin thickness and diameter are about 5 to 10 times higher than the optimal values calculated without respect for manufacturing costs. These values almost correspond to the actual limits of extrusion and press heat-sink manufacturing processes. © 1999 Scripta Technica, Heat Trans Asian Res, 28(2): 138–151, 1999     

Challenges to the Carbon Dioxide Capture and Storage (CCS) Technology

Carbon dioxide Capture and Storage (CCS) technology, which is one of the technologies against global warming, applied to the separation and capture of CO₂ gas and finally storage underground is attracting attention. There are several technologies being developed for CO₂ separation and capture, namely the chemical absorption method, physical absorption method, adsorbing separation method and membrane separation method. These are being developed to apply to postcombustion capture, oxyfuel postcombustion capture, etc. With regard to the CO₂ storage technologies, the method of injection into an aquifer is being developed as the major one, and studies on issues for actual technical application are being conducted in the form of engineering study on the assumed model area. In this report, our expectations toward actual application of the CCS technology, the trends of the CCS technology and other related matters are introduced. Copyright © 2007 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.