An artificial dermis product was applied to full-thickness skin defects in rats and cell infiltration into the collagen matrix was investigated. Host fibroblasts and capillaries infiltrated as far as the upper end of the collagen matrix by day 14 after application. Determination of glycosaminoglycan levels in the matrix showed that hyaluronic acid was generated in a similar amount to that seen in the intact skin by day 14. An autologous thin split-thickness skin graft was placed onto the artificial dermis simultaneously or several days after its application to the defect. The take rate was 100% when a split-thickness skin graft was performed on day 14 after application of the artificial dermis. At 6 weeks after the skin defect was created, the wound area was 80% of the original area and the dermis at the grafted site was as thick as that of normal skin. These results suggested that the artificial dermis provides a good matrix for thin split-thickness skin graft and is useful for the reconstruction of full-thickness skin defects. This method is considered to be an alternative to the conventional procedure using thick skin grafts or skin flaps. 相似文献
OBJECTIVE: To estimate the prevalence of smoking and the attitudes towards the restriction of smoking at work among female nurses in the national hospitals in Japan. DESIGN: Questionnaires mailed to 14 randomly selected national hospitals and sanitariums in Japan in 1993. SUBJECTS: 2207 female nurses. MAIN OUTCOME MEASURES: Smoking status and history, and attitudes towards the restriction of smoking at work. RESULTS: The prevalence of smoking among female nurses was 18.6%, which was higher than the age-adjusted prevalence of the general female population using this study's subjects as a standardised population. Banning smoking in the hospital in which they worked was supported by 15.0%, whereas 81.6% supported the restriction of smoking. CONCLUSIONS: The results showed that smoking is more common among female nurses than among the general female adult population. The survey suggested that nurses favour restriction, but not banning, of smoking. 相似文献
A variety of synthetic methods have been developed for azulene derivatives due to their potential applications in pharmaceuticals and organic materials. Particularly, 2H-cyclohepta[b]furan-2-one and its derivatives have been frequently used as promising precursors for the synthesis of azulenes. In this review, we describe the development of the synthesis of azulenes by the reaction of 2H-cyclohepta[b]furan-2-ones with olefins, active methylenes, enamines, and silyl enol ethers as well as their reactivity and properties. 相似文献
The irregular strip-packing problem (ISP) requires a given set of non-convex polygons to be placed without overlap within a rectangular container having a fixed width and a variable length, which is to be minimized. As a core sub-problem to solve ISP, we consider an overlap minimization problem (OMP) whose objective is to place all polygons into a container with given width and length so that the total amount of overlap between polygons is made as small as possible. We propose to use directional penetration depths to measure the amount of overlap between a pair of polygons, and present an efficient algorithm to find a position with the minimum overlap for each polygon when it is translated in a specified direction. Based on this, we develop a local search algorithm for OMP that translates a polygon in horizontal and vertical directions alternately. Then we incorporate it in our algorithm for OMP, which is a variant of the guided local search algorithm. Computational results show that our algorithm improves the best-known values of some well-known benchmark instances. 相似文献
A Cu on polyimide (COP) substrate was proposed as a MEMS material, and the fabrication process for a flexible thermal MEMS sensor was developed. The COP substrate application to MEMS devices has the advantage that typical MEMS structures fabricated in a SOI wafer in the past—such as a diaphragm, a beam, a heater formed on a diaphragm—can also be easily produced in the COP substrate in the flexible fashion. These structures can be used as the sensing element in various physical sensors, such as flow, acceleration, and shear stress sensors. A flexible thermal MEMS sensor was produced by using a lift-off process and sacrificial etching of a copper layer on the COP substrate. A metal film working as a flow sensing element was formed on a thin polyimide membrane produced by the sacrificial etching. The fabricated flexible thermal MEMS sensor was used as a flow sensor, and its characteristics were evaluated. The obtained sensor output versus the flow rate curve closely matched the approximate curve derived using King’s law. The rising and falling response times obtained were 0.50 and 0.67 s, respectively.
Electrokinetic effects play an important role in microfluidics and nanofluidics. Although the related phenomena are often utilized to control fluid flow and sample transport in lab-on-a-chip devices, their dependency on the surface charges on the channel walls often remain enigmatic. This is mainly due to the lack of adequate experimental methods to analyse the electrical charging of solid/liquid interfaces of interest. To address this need, an experimental set-up—designated as microslit electrokinetic set-up (MES)—has been recently developed and applied for the investigation of charge formation processes at planar solid/liquid interfaces. The device permits to perform streaming potential and streaming current measurements across a rectangular streaming channel formed by two parallel sample carriers (20×10×3 mm3) at variable distance allowing for the determination of the surface conductivity. Utilizing the MES, charge characteristics can be determined for a wide variety of materials prepared as thin films on top of planar glass substrates. Streaming potential and streaming current data permit to investigate the mechanisms of charge formation while surface conductivity data provide information about mobile charge carriers located in different zones at the interface. The applicability of this advanced experimental approach is demonstrated with examples obtained for surfaces with different levels of complexity:
Preferential ion adsorption onto unpolar fluoropolymer (Teflon® AF) films was characterized in simple electrolyte solutions; the results were quantitatively evaluated with respect to interfacial ion concentrations.
Interrelation of charge density and conformation of grafted poly(L-glutamic acid layers) were unravelled from the determination of pH-depended variations of surface conductivity and layer thickness.
The impact of spatial confinements of surface functional groups on their acid–base behaviour was studied with self-assembled monomolecular films of alkanethiols chemisorbed on gold.
Charging of and ion mobility within poly(acrylic acid) (PAA) brushes prepared by a Langmuir–Blodgett technique were analysed at varied pH and ionic strength.
Interfacial modes of adsorbed proteins were distinguished at two polymer surfaces with varied hydrophobicity/charge density.
Ceramics have generally been fabricated from powders by shape forming & sintering methods except for glasses and glass ceramics.
Glasses and glass ceramics can be fabricated by melting methods. The melting method has not only higher productivity but also
higher shape forming ability than powder processes via forming & sintering methods. Thus we have reinvestigated melting methods
in binary and ternary oxides systems to fabricate amorphous bulk ceramics and bulk nano composites. We have successfully fabricated
amorphous phases by simple melt solidification methods in ternary eutectic melts in the HfO2-Al2O3-Gd2O3system. The present study demonstrates the formation of the amorphous phases in quaternary systems HfO2-Al2O3-Gd2O3-Eu2O3. Furthermore, we have also succeeded to fabricate nano-structured bulk ceramics, which consisted of constituent oxide grains
with 20–100 nm in size, by post annealing of the amorphous phase. 相似文献