Oligodendrocytes and their myelin membranes are the apparent target of the autoimmune response that characterizes the human adult central nervous system-demyelinating disease multiple sclerosis. Human oligodendrocytes do not express MHC class II molecules, a requirement for MHC-restricted injury mediated by myelin-reactive CD4+ T cells, the cell type implicated in initiating the disease process. In this study we observed that human adult central nervous system-derived oligodendrocytes can be susceptible to non-MHC-restricted lysis mediated by myelin basic protein-reactive CD4+ T cell lines. Cytotoxicity was significantly greater (37 +/- 4 vs 7 +/- 3%) with cell lines in which a high proportion of cells (mean, 28 +/- 6%) expressed CD56 compared with cytotoxicity mediated by low CD56 cell lines (8 +/- 2%). High CD56 cell lines, when rested in IL-2, lost cytotoxic activity and had reduced expression of CD56 (mean, 5 +/- 2%). CD4+ T cells isolated from short term (3-day) anti-CD3/IL-2-activated mononuclear cell cultures did not express CD56 and were not cytotoxic to oligodendrocytes unless lectin was added. In contrast, an enriched population of non-T cells extracted from the same activated MNC cultures expressed CD56 as well as other NK cell-associated surface molecules and was cytotoxic. These results indicate the potential susceptibility of human oligodendrocytes to non-MHC-restricted injury mediated by both Ag-reactive and nonspecific cellular immune effector cells, with CD56 expression being a common feature of the effector cells. 相似文献
As the global economy develops rapidly, traffic congestion has become a major problem for first-tier cities in various countries. In order to address the problem of failed real-time control of the traffic flow data by the traditional traffic light control as well as malicious attack and other security problems faced by the intelligent traffic light (ITL) control system, a multi-agent distributed ITL control method was proposed based on the fog computing platform and the Q learning algorithm used for the reinforcement learning in this study, and the simulation comparison was conducted by using the simulation platform jointly constructed based on the VISSIM-Excel VBA-MATLAB software. Subsequently, on the basis of puzzle difficulty of the computational Diffie–Helleman (CDH) and Hash Collision, the applicable security control scheme of ITL under the fog computing was proposed. The results reveal that the proposed intelligent control system prolongs the time of green light properly when the number of vehicles increases, thereby reducing the delay time and retention rate of vehicles; the security control scheme of ITL based on the puzzle of CDH is less efficient when the vehicle density increases, while that based on the puzzle of Hash collision is very friendly to the fog equipment. In conclusion, the proposed control method of ITL based on the fog computing and Q learning algorithm can alleviate the traffic congestion effectively, so the proposed method has high security.
International Journal of Computer Vision - Occlusion is probably the biggest challenge for human pose estimation in the wild. Typical solutions often rely on intrusive sensors such as IMUs to... 相似文献
Reflective displays are advantageous in applications requiring low power or daylight readability. However, there are no low‐cost reflective technologies capable of displaying bright colors. By employing photoluminescence to more efficiently use ambient light, we created a prototype display that provides bright, full color in a simple, low‐cost architecture. This prototype includes a novel electrokinetic shutter, a layer that incorporates patterned luminescent red, green, and blue sub‐pixel elements, and a novel optical out‐coupling scheme. The luminescent elements convert otherwise‐wasted portions of the incident spectrum to light in the desired color band, resulting in improved color saturation and lightness. This prototype provides a color gamut that is superior to competing reflective display technologies that utilize color filters in single‐layer side‐by‐side sub‐pixel architectures. The current prototype is capable of switching in <0.5 s; future displays based on an alternative electro‐optic shutter technology should achieve video rate operation. A transflective version of this technology has also been prototyped. The transflective version utilizes its backlight with a power efficiency that is at least three times that of a conventional liquid crystal display. These photoluminescence‐based technologies enable a host of applications ranging from low‐power mobile products and retail pricing signage to daylight readable signage for outdoor advertising segments. 相似文献
