Redox and pH Dual Responsive Polymer Based Nanoparticles for In Vivo Drug Delivery

Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer‐based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy. The nanoparticles contain disulfide bonds within the polymer network, allowing the release of the DOX payload in a reducing environment within the endoplasm of cancer cells. In addition, the loaded drug can also be released under acidic environment. In vitro anticancer studies using redox and pH dual responsive nanoparticles show excellent performance in inducing cell death and apoptosis. Zebrafish larvae treated with DOX‐loaded nanoparticles exhibit an improved viability as compared with the cases treated with free DOX by the end of a 3 d treatment. Confocal imaging is utilized to provide the daily assessment of tumor size on zebrafish larva models treated with DOX‐loaded nanoparticles, presenting sustainable reduction of tumor. This work demonstrates the development of functional nanoparticles with dual responsive properties for both in vitro and in vivo drug delivery in the cancer therapy.     

A Metal–Polyphenol Network Coated Nanotheranostic System for Metastatic Tumor Treatments

As a characteristic trait of most tumor types, metastasis is the major cause of the death of patients. In this study, a photothermal agent based on gold nanorod is coated with metal (Gd³⁺)‐organic (polyphenol) network to realize combination therapy for metastatic tumors. This nanotheranostic system significantly enhances antitumor therapeutic effects in vitro and in vivo with the combination of photothermal therapy (PTT) and chemotherapy, also can remarkably prevent the invasion and metastasis due to the presence of polyphenol. After the treatment, an 81% decrease in primary tumor volumes and a 58% decrease in lung metastasis are observed. In addition, the good performance in magnetic resonance imaging, computerized tomography, and photothermal imaging of the nanotheranostic system can realize image‐guided therapy. The multifunctional nanotheranostic system will find a great potential in diagnosis and treatment integration in tumor treatments, and broaden the applications of PTT treatment.     

Walnut-inspired microsized porous silicon/graphene core–shell composites for high-performance lithium-ion battery anodes

Silicon is considered an exceptionally promising alternative to the most commonly used material, graphite, as an anode for next-generation lithium-ion batteries, as it has high energy density owing to its high theoretical capacity and abundant storage. Here, microsized walnut-like porous silicon/reduced graphene oxide (P-Si/rGO) core–shell composites are successfully prepared via in situ reduction followed by a dealloying process. The composites show specific capacities of more than 2,100 mAh·g^?1 at a current density of 1,000 mA·g^?1, 1,600 mAh·g^?1 at 2,000 mA·g^?1, 1,500 mAh·g^?1 at 3,000 mA·g^?1, 1,200 mAh·g^?1 at 4,000 mA·g^?1, and 950 mAh·g^?1 at 5,000 mA·g^?1, and maintain a value of 1,258 mAh·g^?1 after 300 cycles at a current density of 1,000 mA·g^?1. Their excellent rate performance and cycling stability can be attributed to the unique structural design: 1) The graphene shell dramatically improves the conductivity and stabilizes the solid–electrolyte interface layers; 2) the inner porous structure supplies sufficient space for silicon expansion; 3) the nanostructure of silicon can prevent the pulverization resulting from volume expansion stress. Notably, this in situ reduction method can be applied as a universal formula to coat graphene on almost all types of metals and alloys of various sizes, shapes, and compositions without adding any reagents to afford energy storage materials, graphene-based catalytic materials, graphene-enhanced composites, etc.

Open image in new window

     

生物模板法合成锂离子电池电极材料研究进展

锂离子电池是一类极具潜力的新型二次化学储能器件,被广泛应用于便携式电子设备、电动交通工具和智能电网等领域。高性能电极材料的设计和合成是获得高能量密度、长循环寿命、高安全性锂离子电池的关键。文章针对锂离子电池电极材料存在制备工艺复杂、结构难以控制、活性物质利用率低、循环稳定性和倍率性能差等问题,从生物资源高效利用角度出发,结合生物材料尺寸均匀、形态多变、结构精密、环境友好等优点,综述了生物模板法合成锂离子电池电极材料的研究进展,并对该领域的发展方向进行了展望。     

An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching

The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz.     

LINUX下UBI子系统的研究与应用

对Linux中基于MTD(Memory Technology Device)的UBI(Unsorted Block Images)子系统和基于UBI的UBIFS的二者内部工作机制和算法进行分析,在此基础上着重探讨UBIFS实现快速挂载与I/O的原理.在同一嵌入式Linux系统中分别使用直接基于MTD的JFFS2和基于UBI的UBIFS,对它们的挂载和I/O时间进行性能测试比对,证实UBIFS实现嵌入式Linux文件系统的快速挂载与读写.     

基于Mega169的空调控制器的设计

采用单片机技术,设计了一种车用空调控制器.控制器可对空调的各个部件进行控制,实现制冷制热、调整风量及控制风口的变换等操作.系统采用液晶显示屏显示,由程序控制实现各个环节的功能,方便了汽车驾驶员的操作.该设计具有很高的实用价值,可适用于现有的大多数汽车以及工程车.