Testbed for a scalable terabit optical local area network

The design of a fiber-optic local area network (LAN) demonstration system is described. A complete LAN system would consist of an array of 16 personal computers (PC's), where each PC has a network interface card (NIC) with a parallel fiber-optic datalink to a centralized optoelectronic switch core. The centralized core switches the data generated by 16 NIC's, up to 128 Gbit/s of bandwidth. The demonstrator is designed to scale to terabits of bandwidth by use of an emerging optoelectronic technology, i.e., integrated complementary metal-oxide semiconductor (CMOS) substrates with vertical-cavity surface-emitting laser (VCSEL) and photodetector optical input and output. A subset of the complete system was constructed and is operational. A prototype NIC card, with Motorola Optobus VCSEL transceivers for the optical datalinks, was constructed and is described. A prototype high-speed bipolar switch core, with statically configurable electrical positive-emitter coupled-logic 16 x 16 crossbar switches, CMOS field-programmable gate arrays, and Motorola Optobus transceivers, was constructed and is described. We successfully demonstrated the transmission of high-speed packetized data from one NIC card, through 10 m of parallel fiber ribbon and the centralized switch core, and back to the NIC. We summarize our experiences on the design and testing of our first demonstration system and our development toward a terabit switch core.     

Field-programmable smart-pixel arrays: design, VLSI implementation, and applications

A smart-pixel array is a two-dimensional array of optoelectronic devices that combine optical inputs and outputs with electronic processing circuitry. A field-programmable smart-pixel array (FP-SPA) is a smart-pixel array capable of having its electronic functionality dynamically programmed in the field. Such devices could be used in a diverse range of applications, including optical switching, optical digital signal processing, and optical image processing. We describe the design, VLSI implementation, and applications of a first-generation FP-SPA implemented with the 0.8-microm complementary metal-oxide semiconductor-self-electro-optic effect device technology made available through the Lucent Technologies-Advanced Research Projects Agency Cooperative (Lucent/ARPA/COOP) program. We report spice simulations and experimental results of two sample applications: In the first application, we configure this FP-SPA as an array of free-space optical binary switches that can be used in optical multistage networks. In the second, we configure the device as an optoelectronic transceiver for a dynamically reconfigurable free-space intelligent optical backplane called the hyperplane. We also describe the testing setup and the electrical and the optical tests that demonstrate the correct functionality of the fabricated device. Such devices have the potential to reduce significantly the need for custom design and fabrication of application-specific optoelectronic devices in the same manner that field-programmable gate arrays have largely eliminated the need for custom design and fabrication of application-specific gate arrays, except in the most demanding applications.     

Characterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria

The neurological manifestations of multiple sclerosis (MS) have been considered to result from demyelination of axons with relative preservation of axonal integrity. This concept has been challenged recently by a landmark pathological study, published in the New England Journal of Medicine, which has demonstrated that axonal degeneration is also present. The authors of the study hypothesized that axonal degeneration is the pathological correlate of the irreversible neurological impairment in this disease. However, this hypothesis cannot be reconciled with the clinical results obtained with transcranial applications of AC pulsed electromagnetic fields (EMFs) of picotesla flux density which have shown rapid and sustained improvement of symptoms including normalization of evoked potential responses in patients with chronic progressive or secondary progressive MS without demyelinated areas first undergoing remyelination or transected axons undergoing regeneration. Biochemical studies have shown that MS patients are serotonergically depleted with the extent of cerebral depletion correlating with the degree of motor disability and a chronic progressive course. It is believed that progressive serotonergic neuronal atrophy with synaptic inactivation, not axonal degeneration, are the hallmarks of the disease and that administration of AC pulsed magnetic fields improves symptoms of MS partly through reactivation of serotonergic neurons and amplification of synaptic serotonergic transmission.     

Adjuvant chemotherapy for patients with resected Dukes' C and high-risk B2 colon cancer with fluorouracil and levamisole

Carcinoma of the large bowel is the second leading cause of cancer mortality in Singapore. Although the great majority of patients are discovered at a stage where resection with curative intent is possible, almost half of the patients afflicted will die of it. The combination of 5-fluorouracil + levamisole used in patients with curatively resected high risk Dukes B2 and all Dukes' C colon cancers has been shown to reduce cancer recurrence rate and improve overall survival. Since 1990 adjuvant chemotherapy has been recommended for this group of patients. This report describes patients treated in Singapore, their toxicities and their outcome. A total of 341 patients were treated between 1990 and 1996. Treatment compliance was 71.8%. Toxicity was moderate with mainly grade 1-2 nausea and vomiting, diarrhoea, stomatitis, alopecia, and neutropenia. There was 1 treatment-related death. Median recurrence-free interval was 81 months and median survival was not reached at 90 months. This regimen is tolerable. Until further randomised reports comparing 5-fluorouracil + levamisole to other combinations are available, this combination chemotherapy is recommended to patients after surgical resection of the high risk Dukes' B2 and Dukes' C colon cancer to reduce cancer recurrence and improve overall survival.     

Scrotal skin ulcer in a patient with a previous tonsillectomy because of natural killer cell lymphoma

The CD56+ lymphomas are a recently characterized high-grade malignancy of putative natural killer cell origin. They are mostly localized to the nasal areas but show a propensity to spread to or recur in the skin. We describe a unique case of CD56+ natural killer lymphoma that recurred in scrotal skin in a patient 8 years after an initial limited resection. Although this case was unusual in showing a prolonged period of apparent remission, it illustrated a characteristic clinicopathologic behavior of this rare tumor.     

Sixth International Conference ACID ROCK DRAINAGE 2003

CONFERENCE

Sixth International Conference ACID ROCK DRAINAGE 2003     

Generating compact classifier systems using a simple artificial immune system.

Current artificial immune system (AIS) classifiers have two major problems: 1) their populations of B-cells can grow to huge proportions, and 2) optimizing one B-cell (part of the classifier) at a time does not necessarily guarantee that the B-cell pool (the whole classifier) will be optimized. In this paper, the design of a new AIS algorithm and classifier system called simple AIS is described. It is different from traditional AIS classifiers in that it takes only one B-cell, instead of a B-cell pool, to represent the classifier. This approach ensures global optimization of the whole system, and in addition, no population control mechanism is needed. The classifier was tested on seven benchmark data sets using different classification techniques and was found to be very competitive when compared to other classifiers.     

Nonsmooth feedback stabilizer for strict-feedback nonlinear systems that may not be linearizable at the origin

We present a continuous feedback stabilizer for nonlinear systems in the strict-feedback form, whose chained integrator part has the power of positive odd rational numbers. Since the power is not restricted to be larger than or equal to one, the linearization of the system at the origin may fail. Nevertheless, we show that the closed loop system is globally asymptotically stable (GAS) with the proposed continuous (but, possibly not differentiable) feedback. We formulate a condition that enables our design by characterizing the powers of the given system. The condition also shows that our result is an extension of Qian and Lin [Non-lipschitz continuous stabilizers for nonlinear systems with uncontrollable unstable linearization, Systems Control Lett. 42 (2001) 185–200] where the power of odd positive integers has been considered. New result on the global finite time stabilization problem is also presented.     

Reliability Analysis of Single-Degree-of-Freedom Elastoplastic Systems. I: Critical Excitations

This paper investigates the application of importance sampling method to estimating the first passage probability of single-degree-of-freedom elastoplastic systems subjected to white noise excitations. The importance sampling density is constructed using a conventional choice as a weighted sum of Gaussian distributions centered among design points. It is well known that the design points, or equivalently the critical excitations in the function space, are difficult to obtain for nonlinear hysteretic systems. An efficient method has been developed recently for finding the critical excitations, on which this paper is based. Characteristics of the critical excitation for elastoplastic systems are explored and the efficiency of the resulting importance sampling strategy is critically assessed. It is found that some efficiency is gained by importance sampling over direct Monte Carlo method but to a lesser extent compared to its linear-elastic counterparts. The cause of this drop in efficiency will be investigated. The study calls for revisiting a basic assumption of importance sampling densities constructed using design points, where they are expected to generate samples lying frequently in the failure region, but in reality their capability should not be taken for granted. A companion paper investigates the approximation of the critical excitation that allows its simple determination.