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91.
Dahir Veronica B.; Richardson James T.; Ginsburg Gerald P.; Gatowski Sophia I.; Dobbin Shirley A.; Merlino Mara L. 《Canadian Metallurgical Quarterly》2005,11(1):62
The authors present previously unreported results from a nationwide survey (N=325) of state trial judges (S. I. Gatowski et al., 2001) that was conducted pre-Kumho. The authors report how the 1993 Daubert guidelines were applied to psychological syndrome and profile evidence, and the impact of the decision on the admissibility of such evidence. They found that judges' views of and experience with psychological testimony varied widely and that most judges neither understood nor applied the more technical Daubert guidelines, such as falsifiability and error rate, when assessing psychological evidence. Overall, the findings suggest that Daubert's impact on the admissibility of psychological syndrome and profile testimony is negligible and that most judges are more comfortable with pre-Daubert standards when this type of testimony is proffered. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
92.
Alex Buckley Michelle Murray Susan Eisenbach Sophia Drossopoulou 《Electronic Notes in Theoretical Computer Science》2005,141(1):75
Dynamic linking in modern execution environments like .NET is considerably more sophisticated than in the days of C shared libraries on UNIX. One aspect of this sophistication is that .NET assemblies embed type information about dynamically linked resources.This type information implicitly represents compile-time assumptions about the resources available at run-time. However, the resources available at run-time may differ from those available at compile-time. For example, the execution environment on a mobile phone might provide fewer, simpler classes than on a desktop PC. As bytecode cannot adapt to its execution environment, component reuse is restricted and development costs are increased.We have designed and implemented a “flexible” dynamic linking scheme that binds bytecode as late as possible to the assemblies and classes available in a .NET execution environment. We describe the scheme's integration with the .NET linking infrastructure, review important design decisions and report on experiences with the “Rotor” shared source version of .NET. 相似文献
93.
Zachery R. Reichert Tadas Kasputis Srinivas Nallandhighal Sophia M. Abusamra Amy Kasputis Saloni Haruray Yugang Wang Shamara Williams Udit Singhal Ajjai Alva Frank C. Cackowski Megan E. V. Caram Phillip L. Palmbos Sarah E. Yentz David C. Smith Joshi J. Alumkal Todd M. Morgan 《International journal of molecular sciences》2022,23(1)
The substantial biological heterogeneity of metastatic prostate cancer has hindered the development of personalized therapeutic approaches. Therefore, it is difficult to predict the course of metastatic hormone-sensitive prostate cancer (mHSPC), with some men remaining on first-line androgen deprivation therapy (ADT) for several years while others progress more rapidly. Improving our ability to risk-stratify patients would allow for the optimization of systemic therapies and support the development of stratified prospective clinical trials focused on patients likely to have the greatest potential benefit. Here, we applied a liquid biopsy approach to identify clinically relevant, blood-based prognostic biomarkers in patients with mHSPC. Gene expression indicating the presence of CTCs was greater in CHAARTED high-volume (HV) patients (52% CTChigh) than in low-volume (LV) patients (23% CTChigh; * p = 0.03). HV disease (p = 0.005, q = 0.033) and CTC presence at baseline prior to treatment initiation (p = 0.008, q = 0.033) were found to be independently associated with the risk of nonresponse at 7 months. The pooled gene expression from CTCs of pre-ADT samples found AR, DSG2, KLK3, MDK, and PCA3 as genes predictive of nonresponse. These observations support the utility of liquid biomarker approaches to identify patients with poor initial response. This approach could facilitate more precise treatment intensification in the highest risk patients. 相似文献
94.
The biological activity of lycopene can be enhanced by the presence of these other active antioxidants such as β-carotene, vitamin E, and vitamin C. Since many of these natural antioxidants are consumed together in foods, the potential for synergistic interactions is high in the human diet. The aim of this study was to determine what concentrations and combinations of antioxidants among lycopene, vitamin E, vitamin C, and β-carotene are capable of producing synergistic antioxidant effects, based on tomato-based food products. Solutions of the scavenging capacities of lycopene, vitamin E, vitamin C, and β-carotene, alone and in different combinations were measured using the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Three different levels of each antioxidant were used. A comparison of the scavenging capacity (antioxidant activity) of the combinations of antioxidants to the arithmetic sum of the scavenging capacities of the individual antioxidants was used to calculate the synergistic effects (SEs) between the antioxidants. The results showed that the mixture that had the highest SEs (P<0.01) was the solution combining lycopene (15 μmol/L), vitamin E (5.0 μmol/L), vitamin C (0.16 μmol/L), and β-carotene (10.83 μmol/L). The results suggest that the antioxidant property of this combination was substantially superior to the sum of the individual antioxidant effects, and these interactions can enhance the antioxidant effectiveness of natural antioxidants. The results could guide in the formulation and development of functional food products that have high antioxidant potential. 相似文献
95.
Investigated the mental control of mood and mood-related thought. In Exp 1, Ss reminiscing about a happy or sad event were asked to make their mood positive, were given no instructions, or were asked to make their mood negative. Ss attempting mood control without an imposed cognitive load were successful, whereas those who attempted control while rehearsing a 9-digit number not only failed to control their moods, but also showed self-reported mood change opposite the mood they intended to create. In Exp 2, Ss attempting to control mood-related thoughts under cognitive load showed increased accessibility of those thoughts contrary to the direction of intended control in a Stroop-type color-naming task. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
96.
97.
Karagiannis Georgios Vavliakis Konstantinos Sotiropoulou Sophia Damtsios Argirios Alexiadis Dimitrios Salpistis Christos 《Intelligent Systems, IEEE》2009,24(3):73-81
A bottom-up approach for documenting art objects processes data from innovative nondestructive analysis with signal processing and neural network techniques to provide a good estimation of the paint layer profile and pigments of artwork. The approach also uses Semantic Web technologies and maps concepts relevant to the analysis of paintings and Byzantine iconography to the Conceptual Reference Model of the International Committee for Documentation (CIDOC-CRM). This approach has introduced three main contributions: the development of an integrated nondestructive technique system combining spectroscopy and acoustic microscopy, supported by intelligent algorithms, for estimating the artworks' paint layers profile; mapping of analytical data pertinent to the diagnosis of art paintings to CIDOC-CRM to demonstrate how Semantic Web technologies can benefit cultural heritage; and the introduction of a practical setting that combines different AI fields. 相似文献
98.
Sophia Brilke Julian Resch Markus Leiminger Gerhard Steiner Christian Tauber Peter J. Wlasits 《Aerosol science and technology》2020,54(4):396-409
AbstractMolecular singly charged clusters generated by electrospray sources are commonly used for calibration measurements of ultrafine Condensation Particle Counters (CPCs) in the sub-2?nm size range. This technique has been limited to the smallest singly charged clusters. In this study, we used a bipolar electrospray source combining two electrosprays of opposite polarities to generate singly charged clusters of ammonium salts dissolved in acetonitrile, i.e., tetra-heptyl ammonium bromide (THABr) and tetra-butyl ammonium iodide (TBAI) clusters. A high-resolution UDMA acts as a classifier for positively and negatively charged clusters which are used as mobility standards for the measurement of the complete ascent of the detection efficiency curve of three ultrafine CPCs. The CPCs characterized in this work are two laminar flow-type CPCs using n-butanol (TSI UCPC Model 3776, TSI Inc., Minneapolis, MN USA) and diethylene glycol (DEG) (TSI UCPC Model 3777, TSI Inc.) as working fluid and the turbulent mixing-type DEG-based Particle Size Magnifier (Airmodus A10 PSM). The clusters generated by the bipolar electrospray source are analyzed for their elemental composition using the Atmospheric Pressure interface Time-Of-Flight mass spectrometer (ioniAPi-TOF, Ionicon Analytik GmbH, Austria) in positive and negative ion mode. We present mobility-dependent mass spectra from experiments using the UDMA and the ioniAPi-TOF in series for the analysis of positively charged clusters when operating the electrospray source in unipolar and in bipolar mode to demonstrate the charge reduction and purity of the sample. 相似文献
99.
When assessing historic textiles and considering appropriate conservation, display, and storage strategies, characterizing the physical condition of the textiles is essential. Our work has concentrated on developing nondestructive or micro-destructive methodologies that will permit this. Previously, we have demonstrated a correlation between the physical deterioration of unweighted and "pink" tin (IV) chloride weighted silk and certain measurable spectroscopic and chromatographic signatures, derived from polarized Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy (Pol-ATR) and high-performance liquid chromatography (HPLC) microsampling analyses. The application of the Pol-ATR technique to aged silk characterization has now been extended to include a more comprehensive range of weighting methods and aging regimes. This was intended to replicate the full spectrum of states of deterioration observed in silk textiles, from pristine to heavily degraded. Breaking strength was employed as a measure of the physical integrity of the fibers, and, as expected, decreased with aging. An orientational crystallinity parameter, reflecting the microstructural ordering of the fibroin polymer within the fibers, was derived from the Pol-ATR spectra. A good correlation was observed between the breaking strength of the variety of fibers and this parameter. This suggests that the physical state of historic silk fabrics might be adequately characterized for conservation purposes by such indirect micromethodology. 相似文献
100.
The 5-methyltetrahydrofolate (5MTHF) is the predominate folate form that exists in navy beans and possesses health benefit to human beings. Understanding the degradation kinetics of 5MTHF during navy bean processing would provide useful information that characterizes the influence of processing conditions in order to minimize folate degradation and to maintain overall products quality during the beans’ production. The bio-specific procedures were used for sample preparation and purification, and HPLC techniques were subsequently used for identification and quantitative analysis of 5MTHF in the different treated bean samples. Losses of 5MTHF have been observed in all processed navy beans. Experimental results showed that the soaking time and the seed-to-water ratio were the two most critical factors that affected the stability of 5MTHF during the soaking process. The longer soaking times with larger amounts of soaking water caused higher degradation of 5MTHF. Cooking time and cooking media also played a key role in the degradation of 5MTHF in beans. Pressurized cooking showed the highest reduction of 5MTHF among all the treated bean samples. The treatment causes greater folate loss mainly through the promotion of water penetration and high diffusion, leading to more folate being released from the bean matrix, and accelerating the oxidation and decomposition of folates during cooking. 相似文献