Curcumin–amino acid conjugates: Synthesis,antioxidant and antimutagenic attributes

Curcumin, a natural yellow colourant from turmeric, is insoluble in water. It has been rendered water-soluble by preparation of suitable amino acid derivatives. Several amino acid conjugates of curcumin were synthesised in high yields (45–76%). These curcumin derivatives were soluble in water at 1–10 mg/ml concentrations. Derivatives of curcumin with alkyl-substituted amino acids, such as alanine, valine, serine and cysteine, exhibited smaller IC₅₀ values (∼50%) than did curcumin in antioxidant assays. With respect to antimutagenicity against Salmonella typhimurium TA 98 and TA 1531, the derivatives showed an effect stronger than or, in a few cases, similar to curcumin. These results clearly demonstrated that the conjugation of curcumin at the phenolic position with amino acids, while rendering the molecule water-soluble, led to the improvement of several of its in vitro biological attributes, the effect being more pronounced in the case of specific alkyl-substituted amino acids.     

Preparation and characterization of non-random YBa2Cu3O7-Ag composite

Silver addition to the highT _c superconductor, YBa₂Cu₃O₇ (YBCO) is known to improve its mechanical properties and critical current (J _c) characteristics. We have synthesized the superconductor-metal composite YBCO-Ag by an electroless process at room temperature (using sucrose or hydrazine hydrate in an alkaline medium). The latter method produces a non-random coating whereby each grain of YBCO is coated uniformly by silver. The intrinsic highT _c of 90 K of YBCO can be recovered by compaction of the composite and subsequent heat treatment (900°C and 600°C) in oxygen.     

Do vision and haptics share common representations? Implicit and explicit memory within and between modalities.

Previous assessments of verbal cross-modal priming have typically been conducted with the visual and auditory modalities. Within-modal priming is always found to be substantially larger than cross-modal priming, a finding that could reflect modality modularity, or alternatively, differences between the coding of visual and auditory verbal information (i.e., geometric vs phonological). The present experiments assessed implicit and explicit memory within and between vision and haptics, where verbal information could be coded in geometric terms. Because haptic perception of words is sequential or letter-by-letter, experiments were also conducted to isolate the effects of simultaneous versus sequential processing from the manipulation of modality. Together, the results reveal no effects of modality change on implicit or explicit tests. The authors discuss representational similarities between vision and haptics as well as image mediation as possible explanations for the results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rhythms of Life: Antecedents and Outcomes of Work-Family Balance in Employed Parents.

This study examined antecedents and outcomes of a fourfold taxonomy of work-family balance in terms of the direction of influence (work-family vs. family-work) and type of effect (conflict vs. facilitation). Respondents were full-time employed parents in India. Confirmatory factor analysis results provided evidence for the discriminant validity of M. R. Frone's (2003) fourfold taxonomy of work-family balance. Results of moderated regression analysis revealed that different processes underlie the conflict and facilitation components. Furthermore, gender had only a limited moderating influence on the relationships between the antecedents and the components of work-family balance. Last, work-family facilitation was related to the work outcomes of job satisfaction and organizational commitment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

DSP based inverter control for alternate energy systems

This paper presents a DSP based algorithm to control inverters used in interfacing alternate energy systems with the electric utility. Since a constant and ripple free dc bus voltage is not ensured at the output of alternate energy sources, the main aim of the proposed algorithm is to make the output of the inverter immune to the fluctuations in the dc input voltage. In this paper a modified space vector pulse width modulation (SVPWM) technique is proposed which will maintain the quality of the ac output of the inverter, regardless of the ripple present at the inverter input. The principle is explained qualitatively and extensive experiments have been carried out to verify and validate the proposed algorithm. A 16-bit fixed-point C2000 family DSP from Texas Instruments was used as the controller to implement the proposed control algorithm.     

Condensation on a spray of water drops: A cell model study-I. Flow description

A unit cylinder cell model with a body-fitted coordinate system is employed to analyze the hydrodynamics and heat transfer associated with steam condensation on a spray of equal sized water droplets. The droplets are assumed to be moving in the intermediate Reynolds number regime, Re_g = O(100). The distance between neighboring droplet centers is allowed to be arbitrary in the plane of motion, but the droplets are assumed to be uniformly spaced in the plane perpendicular to the direction of motion. Furthermore, once a particular configuration of the droplets is set, the subsequent spacings between the droplet centers in that configuration are taken to remain constant during the entire condensation process. The formulation entails a simultaneous numerical solution of the quasi-steady elliptic partial differential equations that describe the flow field in both the dispersed and continuous phases in each cell. In part 1 of this study, the results for the velocity, surface pressure and drag are presented. In part II of this study, the results for the condensation induced velocities, surface shear stress, the Nusselt number and the Sherwood number are provided. In both parts of the study, the interactions between neighboring drops have been examined.     

Prediction and assessment of demand response potential with coupon incentives in highly renewable power systems

Demand Response (DR) provides both operational and financial benefits to a variety of stakeholders in the power system. For example, in the deregulated market operated by the Electric Reliability Council of Texas (ERCOT), load serving entities (LSEs) usually purchase electricity from the wholesale market (either in day-ahead or real-time market) and sign fixed retail price contracts with their end-consumers. Therefore, incentivizing end-consumers’ load shift from peak to off-peak hours could benefit the LSE in terms of reducing its purchase of electricity under high prices from the real-time market. As the first-of-its-kind implementation of Coupon Incentive-based Demand Response (CIDR), the EnergyCoupon project provides end-consumers with dynamic time-of-use DR event announcements, individualized load reduction targets with EnergyCoupons as the incentive for meeting these targets, as well as periodic lotteries using these coupons as lottery tickets for winning dollar-value gifts. A number of methodologies are developed for this special type of DR program including price/baseline prediction, individualized target setting and a lottery mechanism. This paper summarizes the methodologies, design, critical findings, as well as the potential generalization of such an experiment. Comparison of the EnergyCoupon with a conventional Time-of-Use (TOU) price-based DR program is also conducted. Experimental results in the year 2017 show that by combining dynamic coupon offers with periodic lotteries, the effective cost for demand response providers in EnergyCoupon can be substantially reduced, while achieving a similar level of demand reduction as conventional DR programs.     

A critical review of models of coupled heat and mass transfer in falling-film absorption

In absorption space-conditioning systems, the performance of the absorber is critical to the overall system performance, size, and first-cost. The objective of this paper is to provide a comprehensive review of the significant efforts that researchers have made to mathematically model the coupled heat and mass transfer phenomena that occur during falling-film absorption. A detailed review of the governing equations, boundary conditions, assumptions, solution methods, results, and validation of these investigations is presented. This review excludes experimental work in this area, the effect of additives, and the effect of non-absorbable gases. It is shown that most work found in the literature has focused on the particularly simplified case of absorption in laminar vertical films of water-lithium bromide. Fewer researchers have considered the important situations of wavy films, turbulent films, and films on horizontal tubes. Investigations of the ammonia-water fluid pair have been generally more empirical in nature and/or restricted to vertical laminar films. This review is used to highlight key areas which need attention such as film and vapor hydrodynamics, especially the non-periodicity, instability, and recirculatory motion of waves in the vertical wall case and droplets and waves in the horizontal tube case. Also the potential interaction of the heat and mass transfer process on the film hydrodynamics, surface wetting, heat transfer in the vapor phase, and common simplifications to the governing equations should all be considered carefully. Finally, emphasis must be placed on experimental validation of the local conditions and transfer processes within the absorber, not just overall transport values.     

Predicting Acute Renal Failure after Cardiac Surgery: Validation and Re‐definition of a Risk‐Stratification Algorithm

Background:  Acute renal failure (ARF) after cardiac surgery is associated with significant morbidity and mortality, irrespective of the need for dialysis. Previous studies have attempted to identify predictors of ARF and develop risk stratification algorithms. This study aims to validate the algorithm in an independent cohort of patients that includes a significant proportion of female and black patients and compares two different definitions of renal outcome.
Methods:  A large single center cardiac surgery database was examined (n, 24,660; 1993–2000) which included 29.9% females and 3.7% black patients. Post‐operative ARF was defined as: a) ARF requiring dialysis, b) > 50% reduction in creatinine clearance relative to baseline or requiring dialysis. Clinical variables related to baseline renal function and cardiovascular disease were used in recursive partitioning analysis for both outcome definitions. Chi‐square goodness of fit analysis was performed to validate the algorithm.
Results:  The frequency of post‐operative ARF requiring dialysis ranged between 0.5 and 15.5% based on the risk categories with the area under the receiver operating characteristic (ROC) curve of 0.78. Using the more inclusive definition of ARF, the frequency was significantly higher ranging from 2.6 to 25%(P < 0.001) with an area under ROC curve of 0.65.
Conclusions:  The renal risk stratification algorithm is valid in predicting post‐operative ARF in an independent cohort of patients, well represented by differences in gender and race. Since the need for dialysis remains subjective, a more objective and inclusive definition of ARF may help in identifying a larger number of patients 'at‐risk'.