Facile Synthesis and Proposed Mechanism of α,ω‐Oxetanyl-Telechelic Poly(3-nitratomethyl-3-methyl oxetane) by an SN2(i) Nitrato Displacement Method in Basic Media

The synthesis of a novel heterocyclic–telechelic polymer, α,ω-oxetanyl-telechelic poly(3-nitratomethyl-3-methyl oxetane), is described. Infrared spectroscopy (IR), gel permeation chromatography (GPC), and nuclear magnetic resonance (NMR) spectroscopy have been used to confirm the successful synthesis, demonstrating the presence of the telechelic-oxetanyl moieties. Synthesis of the terminal functionalities has been achieved via displacement of nitrato groups, in a manner similar to that employed with other leaving groups such as azido, bromo, and nitro, initiated by nucleophiles. In the present case, displacement occurs on the ends of a nitrato-functionalized polymer driven by the formation of sodium nitrate, which is supported by the polar aprotic solvent N,N-dimethyl formamide. The formation of an alkoxide at the polymer chain ends is favored and allows internal back-biting to the nearest carbon bearing the nitrato group, intrinsically in an S_N2(i) reaction, leading to α,ω-oxetanyl functionalization. The telechelic-oxetanyl moieties have the potential to be cross-linked by chemical (e.g., acidic) or radiative (e.g., ultraviolet) curing methods without the use of high temperatures, usually below 100°C. This type of material was designed for future use as a contraband simulant, whereby it would form the predominant constituent of elastomeric composites comprising rubbery polymer with small quantities of solids, typically crystals of contraband substances, such as explosives or narcotics. This method also provides an alternative approach to ring closure and synthesis of heterocycles.     

Waveguide microcavity based on photonic microstructures

A waveguide based microcavity exhibiting a quality factor Q/spl ap/2500 has been realized by incorporating a /spl lambda//4 phase shift into a 1-D photonic microstructure. The microstructure has an overall length of 3 /spl mu/m, consists of a deeply etched grating with very narrow (75 nm) air-gaps and exhibits a third-order stop band in the 800-900 nm wavelength regime. A comparison between measurement and simulation suggests that there is a thin (approximately 18 nm) skin of oxidized material at the etched semiconductor-air interfaces.     

Design and implementation of a hands-free electrolarynx device controlled by neck strap muscle electromyographic activity

The electrolarynx (EL) voice prosthesis is widely used, but suffers from the inconvenience of requiring manual control. Therefore, a hands-free EL triggered by neck muscle electromyographic (EMG) activity was developed (EMG-EL). Signal processing circuitry in a belt-mounted control unit transforms EMG activity into control signals for initiation and termination of voicing. These control signals are then fed to an EL held against the neck by an inconspicuous brace. Performance of the EMG-EL was evaluated by comparison to normal voice, manual EL voice, and tracheo-esophageal (TE) voice in a series of reaction time experiments in seven normal subjects and one laryngectomy patient. The normal subjects produced voice initiation with the EMG-EL that was as fast as both normal voice and the manual EL. The laryngectomy subject produced voice initiation that was slower than with the manual EL, but faster than with TE voice. Voice termination with the EMG-EL was slower than normal voice for the normal subjects, but not significantly different than with the manual EL. The laryngectomy subject produced voice termination with the EMG-EL that was slower than with TE or manual EL. The EMG-EL threshold was set at 10% of the range of vocal-related EMG activity above baseline. Simulations of EMG-EL behavior showed that the 10% threshold was not significantly different from the optimum threshold produced through the process of error minimization. The EMG-EL voice reaction time appears to be adequate for use in a day-to-day conversation.     

Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation

Efficient and safe drug delivery across the blood‐brain barrier (BBB) remains one of the major challenges of biomedical and (nano‐) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)‐based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial ultrasound pulses, USPIO‐MB are destroyed, resulting in acoustic forces inducing vessel permeability. At the same time, USPIO are released from the MB shell, they extravasate across the permeabilized BBB and they accumulate in extravascular brain tissue, thereby providing non‐invasive R ₂*‐based magnetic resonance imaging information on the extent of BBB opening. Quantitative changes in R ₂* relaxometry are in good agreement with 2D and 3D microscopy results on the extravascular deposition of the macromolecular model drug fluorescein isothiocyanate (FITC)‐dextran into the brain. Such theranostic materials and methods are considered to be useful for mediating and monitoring drug delivery across the BBB and for enabling safe and efficient treatment of CNS disorders.     

Toughening of AT-Resins with a Polyphenylquinoxaline

Acetylene terminated (AT) resins are addition-curable thermoset materials which do not generate volatiles during cure and therefore can be fabricated into void-free structures. They retain good thermal and mechanical properties even after exposure to high humidity environments. Their use as composite matrix resins and adhesives has shown promise. These resins, however, are brittle. Molecular structure modifications and blending with thermoplastic modifiers have been used to improve their toughness. In this work, improvement in toughness has been sought through the use of a polyphenylquinoxaline (PPQ) modifier. The blended systems showed improvements in toughness, thermooxidative stability, and lap shear strength over the original AT-resins.     

对一款二手Ku高频头的探讨

前几日，在广州陶街市场淘宝，看到一只牌子为OXFORD(牛津)的二手双本振双极化Ku波段高频头。铭牌标识全是英文，品牌OXFORD，型号TE401，右上角有“CE”标志，品牌Logo下标明是通用LNB。技术指标如下：     

测试与最后工序之融合

目前,半导体工业正以飞快速度不断发展变化。面对成本压力和新封装技术,制造业和设备供货商们在设备能力、工艺和自动控制方面持续不断地加以更新和改进。在测试与最后工序领域中,成功的自动化解决方案是使测试与最后工序相结合,即从根本上转变它的设计形式而大幅度提高效率。它不仅包括大量已封装好的独立组件及高平行性的测试系统,也包括合并高速的最后工序系统。     

Characterization and Modeling of Laser Micromachined Periodically Corrugated Metallic Terahertz Wire Waveguides

Finite element method simulations of periodically corrugated metal terahertz wire waveguides have been conducted with concurrent analysis done on both the near-field confinement properties and the far-field emission properties at the end of the waveguides. This modeling was used to guide the choice of design parameters for the fabrication of waveguides with laser micromachining. The waveguides were characterized with a fiber-coupled terahertz time-domain spectroscopy and imaging system. The propagation properties as well as the frequency dependent diffraction at the end of the wire waveguides were examined and compared to straight, non-engineered metallic wire waveguides.     

Stress and failure probability analysis for a transversely isotropic, brittle, elastic cylinder subjected to internal pressure and axisymmetric thermal loading

Procedures are developed for the determination of the stresses in and thence the probability of failure of a transversely isotropic cylinder made of a brittle material and loaded by an internal pressure and an axisymmetric radial temperature gradient. As examples of the application of the procedures a cylinder is analysed first with isotropic material properties, then with various degrees of anisotropy including both the “fibrous” and “laminar” types. The treatment is non-dimensional; results are presented graphically in the form of failure probability “contours”. For the dimensions and materials considered it is shown that the probability of failure is affected only slightly by the fibrous form of anisotropy but markedly by the laminar form when the thermal loading predominates.