The globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor In vitro for uropathogenic Escherichia coli expressing pap-encoded adhesins

Women with a history of recurrent Escherichia coli urinary tract infections (UTIs) are significantly more likely to be nonsecretors of blood group antigens than are women without such a history, and vaginal epithelial cells (VEC) from women who are nonsecretors show enhanced adherence of uropathogenic E. coli isolates compared with cells from secretors. We previously extracted glycosphingolipids (GSLs) from native VEC and determined that nonsecretors (but not secretors) selectively express two extended globoseries GSLs, sialosyl galactosyl globoside (SGG) and disialosyl galactosyl globoside (DSGG), which specifically bound uropathogenic E. coli R45 expressing a P adhesin. In this study, we demonstrated, by purifying the compounds from this source, that SGG and DSGG are expressed in human kidney tissue. We also demonstrated that SGG and DSGG isolated from human kidneys bind uropathogenic E. coli isolates expressing each of the three classes of pap-encoded adhesins, including cloned isolates expressing PapG from J96, PrsG from J96, and PapG from IA2, and the wild-type isolates IA2 and R45. We metabolically 35S labeled these five E. coli isolates and measured their relative binding affinities to serial dilutions of SGG and DSGG as well as to globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4), two other globoseries GSLs present in urogenital tissues. Each of the five E. coli isolates bound to SGG with the highest apparent avidity compared with their binding to DSGG, Gb3, and Gb4, and each isolate had a unique pattern of GSL binding affinity. These studies further suggest that SGG likely plays an important role in the pathogenesis of UTI and that its presence may account for the increased binding of E. coli to uroepithelial cells from nonsecretors and for the increased susceptibility of nonsecretors to recurrent UTI.     

Properties and Applications of Varistor–Transistor Hybrid Devices

The nonlinear current–voltage characteristics of a varistor device are modified with the help of external agents, resulting in tuned varistor–transistor hybrid devices with multiple applications. The substrate used to produce these hybrid devices belongs to the modified iron titanate family with chemical formula 0.55FeTiO₃·0.45Fe₂O₃ (IHC45), which is a prominent member of the ilmenite–hematite solid-solution series. It is a wide-bandgap magnetic oxide semiconductor. Electrical resistivity and Seebeck coefficient measurements from room temperature to about 700°C confirm that it retains its p-type nature for the entire temperature range. The direct-current (DC) and alternating-current (AC) properties of these hybrid devices are discussed and their applications identified. It is shown here that such varistor embedded ceramic transistors with many interesting properties and applications can be mass produced using incredibly simple structures. The tuned varistors by themselves can be used for current amplification and band-pass filters. The transistors on the other hand could be used to produce sensors, voltage-controlled current sources, current-controlled voltage sources, signal amplifiers, and low-band-pass filters. We believe that these devices could be suitable for a number of applications in consumer and defense electronics, high-temperature and space electronics, bioelectronics, and possibly also for electronics specific to handheld devices.     

An adaptive predistorter for a power amplifier based on adjacentchannel emissions [mobile communications]

A slowly adapting predistorter is presented. The approach is to minimize the transmitter output power in spectral regions occupied only by intermodulation (IM) products. In this way, only a spot power measurement is required. This technique relies on the principle that the power amplifier's characteristics vary slowly with time. By monitoring the out-of-band power one can obtain an estimate for the distortion introduced by the power amplifier. Adaptation is accomplished by iterative adjustment of the predistorter parameters to minimize the IM power. For a polynomial predistorter, the authors analytically demonstrate that the IM power is a quadratic function of the coefficients. A variety of algorithms therefore apply. The authors present an analog static predistortion linearization circuit that uses the envelope of the baseband signal to generate the nonlinear functional used in predistorting the input signal. The improvement obtained with an amplitude-modulated input signal was 15 dB in the third- and 5 dB in the fifth-order intermodulation products. The IM improvement could be maintained with the use of a robust direct search algorithm     

Geometrical analysis of woven fabric microstructure based on micron-resolution computed tomography data

The global mechanical properties of textiles such as elasticity and strength, as well as transport properties such as permeability depend strongly on the microstructure of the textile. Textiles are heterogeneous structures with highly anisotropic material properties, including local fiber orientation and local fiber volume fraction. In this paper, an algorithm is presented to generate a virtual 3D–model of a woven fabric architecture with information about the local fiber orientation and the local fiber volume fraction. The geometric data of the woven fabric impregnated with resin was obtained by micron-resolution computed tomography (μCT). The volumetric μCT-scan was discretized into cells and the microstructure of each cell was analyzed and homogenized. Furthermore, the discretized data was used to calculate the local permeability tensors of each cell. An example application of the analyzed data is the simulation of the resin flow through a woven fabric based on the determined local permeability tensors and on Darcy’s law. The presented algorithm is an automated and robust method of going from μCT-scans to structural or flow models.     

On the expressiveness of second-order spider diagrams

Existing diagrammatic notations based on Euler diagrams are mostly limited in expressiveness to monadic first-order logic with an order predicate. The most expressive monadic diagrammatic notation is known as spider diagrams of order. A primary contribution of this paper is to develop and formalise a second-order diagrammatic logic, called second-order spider diagrams, extending spider diagrams of order. A motivation for this lies in the limited expressiveness of first-order logics. They are incapable of defining a variety of common properties, like ‘is even’, which are second-order definable. We show that second-order spider diagrams are at least as expressive as monadic second-order logic. This result is proved by giving a method for constructing a second-order spider diagram for any regular expression. Since monadic second-order logic sentences and regular expressions are equivalent in expressive power, this shows second-order spider diagrams can express any sentence of monadic second-order logic.     

Evaluating Free Rides and Observational Advantages in Set Visualizations

Free rides and observational advantages occur in visualizations when they reveal facts that must be inferred from an alternative representation. Understanding whether these concepts correspond to cognitive advantages is important: do they facilitate information extraction, saving the ‘deductive cost’ of making inferences? This paper presents the first evaluations of free rides and observational advantages in visualizations of sets compared to text. We found that, for Euler and linear diagrams, free rides and observational advantages yielded significant improvements in task performance. For Venn diagrams, whilst their observational advantages yielded significant performance benefits over text, this was not universally true for free rides. The consequences are two-fold: more research is needed to establish when free rides are beneficial, and the results suggest that observational advantages better explain the cognitive advantages of diagrams over text. A take-away message is that visualizations with observational advantages are likely to be cognitively advantageous over competing representations.

     

Groundwater activation at the Superconducting Super Collider: a new design model

A groundwater activation model was developed for use in designing the accelerators at the Superconducting Super Collider Laboratory. This model is based on the concept of a 4-m-thick "activation zone" surrounding the accelerator enclosure, which contains over 99% of the soil activation caused by beam losses. Empirical shielding formulae based on computer simulations indicate that the soil activation in the activation zone decreases exponentially with distance from the tunnel enclosure. From this assumption, the average activation in the activation zone is derived. It is shown that the average activity concentration in the activation zone is equal to the activity concentration 1 m from the accelerator enclosure. The activation concentration in the water averaged over the volume of the activation zone is compared to the drinking water standards. The goal of this model is to meet the drinking water regulatory standards by averaging the activation in the activation zone. Groundwater activation concentrations have been calculated for the Super Collider utilizing experimental measurements of production cross sections and leachability factors. Comparison is made to the groundwater activation criterion for both routine and accidental beam losses.     

Reformulation of the family life-cycle concept: implications for residential mobility

The author examines the utility of assuming a traditional life cycle framework in social science theory in view of the diversification of patterns of family and non-family structure and behavior. A more comprehensive life cycle model encompassing varied household types is suggested. The appropriateness of this model is investigated, with particular reference to single-headed family households and primary households in the United States