Nanomechanics and Raman spectroscopy of fibrillin 2 knock-out mouse bones

Absence of fibrillin 2 (Fbn2), a non-collagenous bone protein, causes a connective tissue disorder called congenital contractural arachnodactyly (CCA) and has been associated with decreased bone mineral density. Nanoindentation and Raman microspectroscopy have been used to compare the mechanical and chemical properties of cortical bone from femora of Fbn2−/− deficient mice and their wild-type controls (Fbn2+/+). It was found that Fbn2−/− bones have significantly lower hardness and elastic modulus compared to Fbn2+/+ bones, especially in the mid-cortical section. The Raman analysis showed little difference with genotype except for a decrease in type-B carbonate substitution in the endosteal region of Fbn2−/− bones. The results indicate that Fbn2 plays a direct role in determining the mechanical properties of bone.     

Recognizing, assessing, and intervening with problems of professional competence.

Working collaboratively, psychologist educators and trainers at the doctoral, internship, and postdoctoral levels; credentialers; practitioners; and students offer 8 proposals for psychologists to consider in recognizing, assessing, and intervening with problems of professional competence in students and practicing professionals. In the proposals, the authors address the following topics: definitions and categories; preparing the system; self-assessment; remediation; diversity; communication across various levels of the system; confidentiality; and ethical, regulatory, and legal underpinnings. They also propose future directions for the assessment of problems in professional competence in both students and practicing psychologists. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Daily Diary Validity Test of Drinking to Cope Measures.

Data from 2 daily diary studies of stress, negative affect, and drinking were used to examine the correspondence between global self-reports of drinking to cope (DTC) and within-person stress/negative affect-drinking associations. In Study 1, 83 community-residing drinkers recorded data in nightly booklets on negative events, perceived stress, negative affect, and drinking for 60 consecutive days. In Study 2, 88 community-residing drinkers recorded data on negative events and negative interpersonal exchanges nightly and negative affect and drinking in near-real time on palmtop computers for 30 consecutive days. Both studies showed only modest correspondence between self-reported DTC and between-person differences in within-day, daily, and weekly associations between stress/negative affect and drinking. The findings indicate that individuals who report higher DTC simply may drink across a wider variety of conditions than those who report relatively lower DTC. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fire performance of wood (Pinus radiata) treated with fire retardants and a wood preservative

In this work, we co‐formulated an oil‐borne copper naphthenate/permethrin wood preservative system with synthetic polymer‐based fire‐retardant additives prior to the impregnation of Pinus radiata sapwood. We evaluated what effect, if any, the preservative had upon the fire performance properties of the fire retardants and whether the fire retardants impacted on the fungicidal and termiticidal efficacy of the preservative. The fire retardants included halogenated and phosphorus‐based systems. A mass loss calorimeter, in conjunction with a thermopile, was used to measure the time to ignition and the peak heat release rate (PHRR) from which the fire performance index (FPI) was determined. The preservative properties were evaluated using termite and soil‐block decay bioassays. In summary, we found that the rate of fire growth was reduced when the fire retardants were used in combination with the wood preservative. We also found that the PHRR was a better determinant of fire performance than the FPI. The performance of the wood preservative was enhanced against fungal decay and termite attack when used in combination with the fire retardants. The fire retardants also demonstrated some wood preservative properties of their own. Copyright © 2008 John Wiley & Sons, Ltd.     

General relativity and quantum mechanics: towards a generalization of the Lambert W function A Generalization of the Lambert W Function

We present a canonical form for a natural and necessary generalization of the Lambert W function, natural in that it requires minimal mathematical definitions for this generalization, and necessary in that it provides a means of expressing solutions to a number of physical problems of fundamental nature. This generalization expresses the exact solutions for general-relativistic self-gravitating N-body systems in one spatial and one time dimension, and a previously unknown mathematical link between the (1+1) gravity problem and the Schrödinger wave equation.     

Expert identification and selection: Legal liability concerns and directions

Legal liabilities pertaining to the identification and selection of domain experts is an issue that could adversely impact expert systems developers. Problems pertaining to flawed knowledge, improperly defined expertise, and behavioural and psychological impediments are just some of the issues. This paper examines the torts of strict products liability and negligence that system developers could incur as a result of expert-related difficulties. Parallels from legal scholars and federal and state court decisions are discussed relevant to expert system projects and developers. The paper concludes with a presentation of steps that systems developers can take to minimize potential legal liability.     

Extrahepatic metabolism of 4-methylumbelliferone and lidocaine in the anhepatic rabbit

OBJECTIVE: The initially well-fixed implants of total hip replacement (THR) are in the long-term subject to aseptic loosening. Many cytokines can contribute to osteolysis due to osteoclast recruitment and/or activation. However, in this respect tumor necrosis factor-alpha (TNF-alpha) plays a pivotal role, because it upregulates interleukin-1 and 6 and granulocyte-macrophage colony stimulating factor. The aim of this study was to assess the eventual presence, cellular localization and extent of expression of TNF-alpha in the synovial-like membrane at the implant or at the cement to bone interface compared to control synovial membrane. METHODS: Twenty samples from the synovial-like membrane of the periprosthetic tissues were compared to control samples. TNF-alpha containing cells were visualized using an avidin-biotin-peroxidase complex (ABC) method and analyzed by light microscopy, double labelling and image analysis. RESULTS: TNF-alpha was found in the periprosthetic tissues in fibroblasts and vascular endothelial cells, but mainly in the macrophages was it found to coincide with areas containing implant-derived debris. TNF-alpha containing cells were more numerous in the synovial-like membrane in the interface tissue from the proximal stem area (2816 +/- 318 cells) than in the control synovial membrane (565 +/- 93 cells, p < 0.01). Interestingly, similarly high TNF-alpha expression (3452 +/- 582 cells) was also seen in the synovial-like membrane of the pseudocapsule. CONCLUSION: These findings suggest that the foreign body-type host reaction caused by THR is characterized by the high expression of TNF-alpha. Because such expression occurred in the interface tissue between the implant and surrounding bone, TNF-alpha, due to its pivotal direct and indirect role in the activation and recruitment of osteoclasts, may contribute to periprosthetic osteolysis and to the loosening of THR.     

Integration of knowledge-based systems with data processing

Transaction Oriented Prolog-Online Environment is a multi-user, mainframe implementation of the logic programming language Prolog, specially designed and developed for the data processing environment. This article describes the background, functionality, implementation and use of TOP-ONE, stressing that applications of knowledge-based systems technology to data processing environments will achieve full success only when existing systems and existing conventional data are incorporated within the applications.     

Adolescent egocentrism and formal operations: Tests of a theoretical assumption.

The theoretical relation between adolescent egocentrism and formal operations was addressed in 2 studies. In Study 1, this relation was assessed with the Adolescent Egocentrism Scale (AES; R. Enright et al, see PA, Vols 63:5127 and 65:10218) and a battery of formal reasoning tasks administered to 183 6th-, 8th-, 10th-, and 12th-graders. The results reveal only significant negative or nonsignificant correlations between the measures in early adolescence. There was also no evidence of significant developmental covariation from early to middle adolescence. The validation effort was extended in Study 2 to include 2 measures of adolescent egocentrism (AES and the Imaginary Audience Scale [IAS; D. Elkind and R. Bowen, see PA, Vol 62:5769]) and a 2nd battery of formal operations problems. These measures were administered to 117 7th-, 9th-, and 11th-graders and to 56 undergraduates. There was once again no evidence of significant developmental covariation among the measures. The correlations between the AES and IAS were modest, reflecting differences in the nature and content of the measures. It is concluded that little support exists in this study or in the literature for the crucial theoretical assumption of adolescent egocentrism. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)