Electrospinning highly oriented and crystalline poly(lactic acid) fiber mats

In recent years, there has been an increased focus on sustainable, green alternatives with similar properties to conventional petroleum-based polymers. Poly(lactic acid) (PLA) is a biodegradable biopolymer which exhibits mild piezoelectric properties and has good processability which gives it potential for use in numerous existing and novel applications. The purpose of this study was to produce highly oriented and crystalline PLA electrospun fiber mats for piezoelectric applications. In order to yield a high piezoelectric constant, high crystallinity and fiber orientation are necessary. A two parallel collector set up was used to mechanically orient the fibers in the space between two copper electrodes. Voltage and feed rate were adjusted to produce smooth, oriented fibers with average diameters ranging 0.73–1.19 μm. Crystallinity and orientation were increased via hot drawing of the fiber mats and were maximized between 40 and 50 % and greater than 50 %, respectively.     

Distributed topology management for wireless multimedia sensor networks: exploiting connectivity and cooperation

In this paper, we propose a distributed topology management algorithm, named T‐Must, which orchestrates coalition formation game between camera and scalar sensor (SS) nodes, for use in wireless multimedia sensor networks. In the proposed solution, connectivity among the peer camera sensor (CS) nodes is maintained, and coverage is ensured between them. Only the scalar data are not sufficient to describe an event in a particular monitored area. In many cases, multimedia data (specifically, video data) are required to provide more precise information about the event. As the CS nodes, which sense and transmit multimedia data, are costlier than the SS nodes, the former are deployed in the monitored area in lesser numbers compared to the latter ones. In case of CS nodes, power consumption due to sensing is also significant, similar to power consumption for the transmission and reception of packets. Therefore, in this work, in order to increase the network lifetime, topology is controlled by forming coalition between the CS and SS nodes. Upon occurrence of an event, the SS nodes send scalar data to their associated CS nodes. If the scalar data received from SS nodes cross a preconfigured threshold, the associated CS node in the coalition starts sensing the event, captures the video data, and forwards the video data toward other coalitions or sink. Copyright © 2014 John Wiley & Sons, Ltd.     

The role of nanocrystalline titania coating on nanostructured austenitic stainless steel in enhancing osteoblasts functions for regeneration of tissue

In the context of osseointegration of metallic implants, while nanostructuring the surface favorably modulates cellular response, the disinfective attributes required during the healing process are not available. Thus, in the present study, we demonstrate that nanocrystalline titania provides cumulative benefit of enhancing osteoblasts functions to promote the efficacy of metal implants together with the disinfective attributes. To this end, the primary objective here is to examine the select functions of bone forming cells (osteoblasts) on electrocrystallized nanonodular titania-coated nanograined/ultrafine grained (NG/UFG) austenitic stainless steel. The accompanying objective is to study the disinfective/antimicrobial activity. To the best of our understanding this is the first study of nanophase titania on a non-titanium substrate. The osteoblasts functions were investigated in terms of cell attachment, proliferation, and quantitative analysis of proteins, actin and vinculin. In comparison to the bare NG/UFG substrate, the nanophase titania-coated substrate exhibited higher degree of cell attachment and proliferation which are regulated via cellular and molecular interactions with proteins, actin and vinculin. The enhanced functions of osteoblasts suggest that nanophase titania adsorbs extracellular matrix proteins, fibronectin and vitronectin from serum enhancing protein, with subsequent binding of integrins and osteoblasts precursor to titania. The antimicrobial attributes assessed in terms of degradation of methyl orange and effectiveness in killing E. coli supports the viewpoint that large surface area of titania would be instrumental in reducing the detrimental effect of biologically reactive oxygen species produced by macrophages in the vicinity of the metal bone/implant interface. In summary, the study provides some new insights concerning nanostructuring of metallic substrates with specific physical and surface properties for medical devices with significantly improved cellular response.     

Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis,loading efficiency,and drug release response

A novel folate-decorated and graphene mediated drug delivery system was prepared that involves uniquely combining graphene oxide (GO) with anticancer drug for controlled drug release. The nanocarrier system was synthesized by attaching doxorubicin (DOX) to graphene oxide via strong π–π stacking interaction, followed by encapsulation of graphene oxide with folic acid conjugated chitosan. The π–π stacking interaction, simplified as a non-covalent type of functionalization, enables high drug loading and subsequent controlled release of the drug. The encapsulated graphene oxide enhanced the stability of the nanocarrier system in aqueous medium because of the hydrophilicity and cationic nature of chitosan. The loading and release of DOX indicated strong pH dependence and imply hydrogen-bonding interaction between graphene oxide and DOX. The proposed strategy is advantageous in terms of targeted drug delivery and has high potential to address the current challenges in drug delivery. Thus, the prepared nanohybrid system offers a novel formulation that combines the unique properties of a biodegradable material, chitosan, and graphene oxide for biomedical applications.     

Silver–clay nanohybrid structure for effective and diffusion-controlled antimicrobial activity

We describe here the synthesis and antimicrobial activity of silver–clay nanohybrid structure that was processed to exhibit a combination of accelerated and diffusion-controlled antimicrobial activity, with long term impact. The antimicrobial activity is assessed in terms of interaction with Escherichia coli, where the constituents of the nanohybrid structure play a synergistic role. Clay provides a physically stable surface for nucleation of silver nanoparticles. Additionally, the parallel- stacked layered structure of clay facilitates diffusion-controlled antimicrobial activity of in-situ precipitated silver. The antimicrobial activity is about four orders of magnitude greater than ex-situ precipitated bare silver particles. The study emphasizes the significance of controlling antimicrobial activity in nanostructured systems, which in the present case is enhanced and controlled antimicrobial activity with long term implication.     

Facile one-step transfer process of graphene

Chemical vapour deposition (CVD) is emerging as a popular method for growing large-area graphene on metal substrates. For transferring graphene to other substrates the technique generally used involves deposition of a polymer support with subsequent etching of the metal substrate. Here we report a simpler one-step transfer process. Few-layer graphene (FLG) grown on a Cu substrate were transferred to a silanized wafer by just pressing them together. Hydrogen bonding between the hydroxyl group on FLG and the amine group on silane molecules facilitate the transfer.     

Macro-to-micro porous special bioactive glass and ceftriaxone-sulbactam composite drug delivery system for treatment of chronic osteomyelitis: an investigation through in vitro and in vivo animal trial

A systematic and extensive approach incorporating in vitro and in vivo experimentation to treat chronic osteomyelitis in animal model were made using antibiotic loaded special bioactive glass porous scaffolds. After thorough characterization for porosity, distribution, surface charge, a novel drug composite were infiltrated by using vacuum infiltration and freeze-drying method which was subsequently analyzed by SEM-EDAX and studied for in vitro drug elution in PBS and SBF. Osteomyelitis in rabbit was induced by inoculation of Staphylococcus aureus and optimum drug-scaffold were checked for its efficacy over control and parenteral treated animals in terms of histopathology, radiology, in vivo drug concentration in bone and serum and implant-bone interface by SEM. It was optimized that 60P samples with 60-65% porosity (bimodal distribution of macro- to micropore) with average pore size ~60 μm and higher interconnectivity, moderately high antibiotic adsorption efficiency (~49%) was ideal. Results after 42 days showed antibiotic released higher than MIC against S. aureus compared to parenteral treatment (2 injections a day for 6 weeks). In vivo drug pharmacokinetics and SEM on bone-defect interface proved superiority of CFS loaded porous bioactive glass implants over parenteral group based on infection eradication and new bone formation.     

Vertically aligned ZnO nanowire arrays in Rose Bengal-based dye-sensitized solar cells

We fabricate dye-sensitized solar cells (DSSC) using vertically oriented, high density, and crystalline array of ZnO nanowires, which can be a suitable alternative to titanium dioxide nanoparticle films. The vertical nanowires provide fast routes or channels for electron transport to the substrate electrode. As an alternative to conventional ruthenium complex, we introduce Rose Bengal dye, which acts as a photosensitizer in the dye-sensitized solar cells. The dye energetically matches the ZnO with usual KII₂ redox couple for dye-sensitized solar cell applications.     

Domestic fuel energy consumption in an Indian urban ecosystem

Berhampur is one of the oldest and biggest towns of Orissa State where 93% of people earn their living from non-primary economic activities. The fuel consumption structure reveals an element of rural bias since the domestic sector derives 49% of its energy used for cooking and heating from biomass sources. Firewood is the only fuel used by all income groups and almost all occupations. Other traditional fuels such as dungcake, agricultural waste and leaf litter are used in the town with different degrees of dominance in various occupation groups and income classes. The inequality of income distribution is reflected in the fuel consumption structure of the rich and poor with greater dependence on non-biomass in the high income group and biomass in the low income group. Family size is an important determinant of biomass fuel use. For the urban poor, there is a relationship between income and fuel consumption. There exists scope for enlarging the biomass base by utilising the available bio-wastes and developing a green belt around the town. This requires some rural features in the urban area using new technologies.