Effects of aging, diet, and sex on plasma glucose, fructosamine, and lipid concentrations in barrier-raised Fischer 344 rats

We studied the relationships of plasma glucose, fructosamine, triglycerides, and cholesterol as a function of age, gender, and diet in barrier-raised Fischer 344 rats aged 5 to 26 months, fed a diet either ad libitum or restricted to 60% of the ad libitum caloric intake. The complex relationships of these plasma levels to age, gender, and diet led to the development of a model with age, diet, and sex as covariates. Overall, fasting plasma glucose concentrations were reduced by approximately 25% in rats on the restricted diet, compared to ad libitum-fed animals. There was a significant age-dependent decline in glucose levels in male animals, whereas in females there was an increase in plasma glucose with aging. Plasma fructosamine levels in calorie-restricted animals, overall, were reduced by 7% compared to levels in animals fed ad libitum. There was a significant positive correlation between plasma glucose and fructosamine levels. Mean plasma triglyceride content was decreased by 50% in calorie-restricted rats compared to ad libitum-fed animals. A significant decrease in triglyceride levels with increasing age was seen in male animals, and an increase with aging in females. There was a significant positive correlation between plasma glucose and triglyceride levels. Plasma cholesterol levels in calorie-restricted animals were reduced by 7% compared to levels in ad libitum-fed animals. An increase of cholesterol concentration with aging was significant in both males and females. Analysis of the data showed that there were significant differences between male and female Fischer 344 rats in the response of plasma glucose and fructosamine to aging and calorie restriction. Changes of plasma triglyceride and cholesterol with aging and dietary calorie restriction were also different in males and females. Studies of the effect of aging on glycemia and blood lipid content should take into account the contributions of animal sex.     

Optimizing the costs of hierarchical quorum consensus

 We study the problem of how to minimize the cost of maintaining consistency among at least N copies of an object in an enviroment where the mix of read and write operations can vary. Quorum consensus requires that read and write operations must assemble appropriate quorums before an operation can succeed. The cost of an operation is proportional to the size of a quorum, and the objective is obviously to minimize the cost while still maintaining consistency. It is known that the quorum size can be reduced by organizing a number of copies into logical structures such as grids and hierarchies. In this paper, we show (a) how methods based on grids and hierarchies can be treated in a common framework, and (b) how these hierarchies can be optimized so as to minimize the cost of consensus. Of course, the optimal solution depends upon the mix of read and write operations that is present. Consequently, given N copies of an object and a ratio of write operations F, our algorithms determine the optimal values for the number of levels in the hierarchy and the read/write quorum sizes at each level. The algorithms, which run in O(N ^1.63) and O(N ²) time, were tested, and the results are reported and discussed. Received September 1, 1992/February 16, 1995     

Synthesis and biological activity of novel thiazolidinediones

Novel compounds having a dual pharmacophore were synthesised and evaluated for their insulin sensitiser and anti-inflammatory properties in different animal models.     

Thermal performance of “still on roof” system

This paper presents an analysis of periodic heat flux through a roof, on which a solar still has been placed. It is seen that on a typical hot day in Delhi, for high reflectivity of the bottom of the basin (on account of deposits or otherwise) the daily heat flux in the room gets reduced by 40% and the production of distilled water is 0.6 kg/m² day; the produced swings in the heat flux also get reduced in magnitude. For a typical cold day in Delhi, if a black dye is mixed with basin water the daily heat flux in the room increases by a factor of two and the yield of the distillate becomes 5.0 kg/m² day.     

Reliability Bounds for Decomposable Multi-component Systems

This paper obtains lower and upper bounds for decomposable multi-component complex systems. Some particular cases are discussed.     

Formation of M23C6 type carbides in heat-treated extra low carbon Mn-Si and Mn-Si-Nb high strength low alloy “mar” steels

Structural investigations in extra low carbon mar steels with nominal compositions A1 (4 Mn-1.0 Si), A2 (4 Mn-1.0 Si – 0.042 Nb), A3 (～ 5 Mn-1.5 Si), A4 (2.6 Mn-1.0 Si) and A5 (～ 5 Mn-2.5 Si) in the heat treated condition by X-ray diffraction technique (Debye-Scherrer method) for identifying strengthening mechanisms. Results on the formation of M₂₃C₆ type carbide either singly (in most cases) or in combination with austenite. Discussion pertaining to 1. identification of factors promoting the structural changes and, 2. their likely effect on mechanical properties.     

On profit considerations of a maintained system with minor repair

A maintained system is considered which can exit from the operable state to two states: failed and less productive. Profit equations are developed to study the system behaviour and a condition is derived under which the system can be profitably operated in a less productive state. A numerical example has been included to illustrate the results.     

Techniques based on genetic algorithms for large deflection analysis of beams

A couple of non-convex search strategies, based on the genetic algorithm, are suggested and numerically explored in the context of large-deflection analysis of planar, elastic beams. The first of these strategies is based on the stationarity of the energy functional in the equilibrium state and may therefore be considered weak. The second approach, on the other hand, attempts to directly solve the governing differential equation within an optimisation framework and such a solution may be thought of as strong. Several numerical illustrations and verifications with ‘exact’ solutions, if available, are provided For communication     

Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies

Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging (MRI) contrast agents or in drug delivery applications. In this study, a novel approach to prepare magnetic polymeric nanoparticles with magnetic core and polymeric shell using inverse microemulsion polymerization process is reported. Poly(ethyleneglycol) (PEG)-modified superparamagnetic iron oxide nanoparticles with specific shape and size have been prepared inside the aqueous cores of AOT/n-Hexane reverse micelles and characterized by various physicochemical means such as transmission electron microscopy (TEM), infrared spectroscopy, atomic force microscopy (AFM), vibrating sample magnetometry (VSM), and ultraviolet/visible spectroscopy. The inverse microemulsion polymerization of a polymerizable derivative of PEG and a cross-linking agent resulted in a stable hydrophilic polymeric shell of the nanoparticles. The results taken together from TEM and AFM studies showed that the particles are spherical in shape with core-shell structure. The average size of the PEG-modified nanoparticles was found to be around 40-50 nm with narrow size distribution. The magnetic measurement studies revealed the superparamagnetic behavior of the nanoparticles with saturation magnetization values between 45-50 electromagnetic units per gram. The cytotoxicity profile of the nanoparticles on human dermal fibroblasts as measured by standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that the particles are nontoxic and may be useful for various in vivo and in vitro biomedical applications.