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191.
Subha Balakrishnan Varun Prasath Padmanabhan Ravichandran Kulandaivelu T.S. Sankara Narayanan Nellaiappan Suresh Sagadevan Suriati Paiman Faruq Mohammad Hamad A. Al-Lohedan Prasanna Kumar Obulapuram Won Chun Oh 《Ceramics International》2021,47(4):5061-5070
Hydroxyapatite (HAP) is the naturally occurring mineral form of calcium apatite and the most studied material as a bone substituent. Considering HAP's inherent properties, this study explored changes in HAP's characteristics from doping with other metals such as Fe. To form pure HAP and Fe-HAP with different amounts of Fe, we used the hydrothermal approach, and the composites that formed were thoroughly analyzed for their crystallinity, surface bonding, morphology, magnetic behavior, mechanical strength, biocompatibility, hemocompatibility, and in vitro cytotoxicity. The powder XRD studies confirmed the samples' crystallinity, and the lowest crystalline size was 19.7 nm in 10Fe-HAP. The FTIR analysis confirmed the formation of HAP by the hydroxyl, phosphate, and carbonate groups. The FESEM demonstrated that the morphology of the pure HAP was rod-shaped, which transformed into spheres after Fe doping. The EDS analysis confirmed the successful formation of HAP and Fe-HAP composites. The magnetic studies indicated the diamagnetic behavior of the pure HAP, while the Fe-doped HAPs had a superparamagnetic nature with saturation magnetizations (Ms) of 2Fe-HAP, 4Fe-HAP, and 10Fe-HAP at 0.0062, 0.0092, and 0.029 emu/g respectively. Assessment of the mechanical properties, biocompatibility, hemocompatibility, and cytotoxicity indicated that the Fe-doped HAPs were superior to the pure HAP, and among the Fe-HAPs, the 10Fe-HAP) had the highest amount of Fe and the best characteristics. The studies also indicated that Ca2+ interactions influenced the cells via HAP doping with that of Fe, equally increasing the physicochemical and biological properties. 相似文献
192.
Machine Learning - Covariance estimation for high-dimensional datasets is a fundamental problem in machine learning, and has numerous applications. In these high-dimensional settings the number of... 相似文献
193.
We propose a way to measure the absorber reflectivity at a low cost. Only one simple antenna with a small radiating aperture and a frequency‐domain instrument are utilized. The previously used equation for calculating the reflectivity of an absorber is inaccurate, and, therefore, a new equation is derived based on multiple reflection analysis and three test models. Notably, the reflection coefficient of the antenna is included in the derived equation. The accuracy of the proposed method is proven through simulation and measurements. It can be easily applied to a product examination by absorber manufacturers and customers owing to its advantages of simplicity, cost effectiveness, and non‐cutting examination. 相似文献
194.
Investors in futures market used to employ trading system which depends on reference pattern (template) to detect real-time buy or sell signal from the market. Indeed they prepare in advance a number of reference patterns that market movement might follow, and then match the current market with one of reference patterns. One popular way to prepare templates is to fix a relatively small number of them which represent possible market movements efficiently. The underlying assumption of this approach is of course that the current market movement is close enough to one of the templates. However, there is always a calculated risk that the current market is close to none of them sufficiently. In this article we investigate the issue of appropriate number of templates (or template cardinality I) in terms of profitability. We will show that one may improve profitability by increasing I and that random pattern sampling plays a key role in such case. An empirical study is done on the Korean futures market. 相似文献
195.
Food Science and Biotechnology - Polyphenols are secondary metabolites produced in higher plants. They are known to possess various functional properties in the human body. Polyphenols also exhibit... 相似文献
196.
Lee So-Yeon Kwon Ki-Hyun Chai Changhoon Oh Se-Wook 《Food science and biotechnology》2018,27(2):599-605
Food Science and Biotechnology - This study was conducted to compare the growth parameters of Listeria monocytogenes between beef isolates and Type strains in raw beef. Beef was artificially... 相似文献
197.
A quality-by-design approach was adopted to develop telmisartan potassium (TP) tablets, which were bioequivalent with the commercially available Micardis® (telmisartan free base) tablets. The dissolution pattern and impurity profile of TP tablets differed from those of Micardis® tablets because telmisartan free base is poorly soluble in water. After identifying the quality target product profile and critical quality attributes (CQAs), drug dissolution, and impurities were predicted to be risky CQAs. To determine the exact range and cause of risks, we used the risk assessment (RA) tools, preliminary hazard analysis and failure mode and effect analysis to determine the parameters affecting drug dissolution, impurities, and formulation. The range of the design space was optimized using the face-centered central composite design among the design of experiment (DOE) methods. The binder, disintegrant, and kneading time in the wet granulation were identified as X values affecting Y values (disintegration, hardness, friability, dissolution, and impurities). After determining the design space with the desired Y values, the TP tablets were formulated and their dissolution pattern was compared with that of the reference tablet. The selected TP tablet formulated using design space showed a similar dissolution to that of Micardis® tablets at pH 7.5. The QbD approach TP tablet was bioequivalent to Micardis® tablets in beagle dogs. 相似文献
198.
Shin Nina Kim Donghui Park Sangwook Oh Jungsuk 《Information Systems and E-Business Management》2018,16(1):125-154
Information Systems and e-Business Management - Mobile commerce, or m-commerce, has quickly become a powerful, indispensable approach for diverse business to consumer (B2C) industries to secure... 相似文献
199.
200.