The modified J-integral and the stress intensity factor based on linear elastic fracture mechanics can be applied to predict the growth of interfacial delamination in integrated circuit (IC) packages. One of the key parameters required is the interfacial fracture toughness. This paper describes the measurement of the interfacial fracture toughness as a function of temperature and relative humidity using a three-point bending test. The interfacial fracture toughness was found to decrease with temperature and relative humidity. It is proposed that delaminations propagate from very small voids or defects present at the interface. The effect of the location of these interfacial defects or cracks on delamination was studied. The IC package evaluated in this paper was an 80-pin quad flat package with a 0.2 mm defect or crack at the edge or at the center of the interface. It was found that as the temperature of the package was increased, the stress intensity factor of the edge crack was higher than that of the center crack. However, whether the edge crack will propagate first as temperature is increased depends on the ratio of mode II interface toughness to that of the mode I interface toughness. For the package under investigation, it was established that when this ratio is less than 2.69 the edge crack would propagate first, otherwise the center crack would. For small defects, it was found that the water vapor pressure developed at the interface did not have a significant effect on the value of the crack-tip stress intensity factor 相似文献
A new, to our knowledge, two-dimensional phase-unwrapping algorithm is proposed. The algorithm, which is based on the global continuity of physical information (e.g. the three-dimensional surface profile of an object) being measured, uses the principle of least-phase difference to rectify errors caused by an erroneous 2pi-phase jump in the initial unwrapped phase map obtained by the conventional phase-unwrapping method. Experimental results show that the proposed algorithm works well on a phase map that contains error sources, such as noises, phase discontinuity of more than pi, and insufficient sampling. Moreover, the algorithm is most suitable for unwrapping a phase map generated during shape measurement with a step-change surface on the test object, which is usually a critical problem in shape measurement. 相似文献
An optical method has been developed to measure the deformation of a membrane in a microphone. A fringe projector that consists of an optical fiber and an optical wedge is described and analyzed by geometric optics. A three-step phase-shifting technique that involves the introduction of an arbitrary phase is discussed. The fine fringe patterns projected onto a small test surface are captured by a CCD camera mounted on a long-distance microscope. With the aid of a phase-shifting technique and signal-demodulating techniques, the proposed setup is capable of measuring deformation of the membrane of the order of as much as submicrometers. 相似文献
Platelet-activating factor (PAF) is produced by preimplantation embryos and may be involved in the earliest stages of embryo-maternal dialogue. This study explored the potential effects of PAF acting as a signalling agent on human Fallopian tubal epithelial cells grown as a polarized layer in primary culture. The response of the tubal epithelium was assessed in terms of the transepithelial potential difference and short-circuit current (I(scc)), which were recorded using a modified Ussing chamber. Resistance was calculated from the measurements of potential difference and I(scc). PAF (1.9 nmol to 1.9 micromol l(-1)) administered to the apical surface of the cells produced a marked, transient increase in both potential difference and I(scc) in a dose-dependent manner. The mode of action of PAF on the electrophysiological responses of human tubal epithelial cells was investigated. Blockers of Na(+), K(+) and voltage-operated Ca(2+) channels had little effect on PAF action. However, incubation of the epithelial cells in Cl(-)free medium or with a blocker of the Na(+)-K(+)-2Cl(-) cotransporter (Furosemide) reduced the effect of PAF. Blockade of chloride-bicarbonate channels with 4-acetamido-4'-iso-thiocyanostilbene-2.2'-disulphonic acid (SITS) reduced the effect of low doses of PAF only. These results indicate that PAF influences the movement of chloride ions across the tubal epithelial cell and is a candidate molecule for initial embryo-maternal dialogue. 相似文献
The paper presents a dielectrophoretic chip, fully enclosed, with bulk silicon electrodes fabricated using wafer-to-wafer bonding techniques and packaged at the wafer level. The silicon electrodes, which are bonded to two glass dies, define in the same time the walls of the microfluidic channel. The device is fabricated from a silicon wafer that is bonded (at wafer level) anodically and using SU8 photoresist between two glass wafers. The first glass die includes drilled holes for inlet/outlet connections while the second glass die assure the electrical connections, through via holes and a metallization layer, between the silicon electrodes and a printing circuit board. 相似文献
This paper reports the highest etch depth of annealed Pyrex glass achieved by wet etching in highly concentrated HF solution, using a low stress chromium–gold with assistance of photoresist as masking layer. The strategies to achieve that are: increasing the etch rate of glass and simultaneously increasing the resistance of Cr/Au mask in the etchant. By annealing the Pyrex glass and using a highly concentrated HF acid, a high etch rate can be obtained. Furthermore, a method to achieve a good resistance of the Cr/Au masking layer in the etching solution is to control the residual stress and to increase the thickness of Au deposition up to 1 μm. In addition, the presence of a hard baked photoresist can improve the etching performance. As a result, a 500-μm thick Pyrex glass wafer was etched through.
Since the ChiMerge algorithm was first proposed by Kerber (1992), it has become a widely used and discussed discretization method. The Chi2 algorithm is a modification to the ChiMerge method. It automates the discretization process by introducing an inconsistency rate as the stopping criterion and it automatically selects the significance value. In addition, it adds a finer phase aimed at feature selection to broaden the applications of the ChiMerge algorithm. However, the Chi2 algorithm does not consider the inaccuracy inherent in ChiMerge's merging criterion. The user-defined inconsistency rate also brings about inaccuracy to the discretization process. These two drawbacks are first discussed in this paper and modifications to overcome them are then proposed. By comparison, results with the original Chi2 algorithm using C4.5, the modified Chi2 algorithm, performs better than the original Chi2 algorithm. It becomes a completely automatic discretization method 相似文献
This paper proposes a modified version of support vector machines (SVMs), called ε-descending support vector machines (ε-DSVMs),
to model non-stationary financial time series. The ε-DSVMs are obtained by incorporating the problem domain knowledge – non-stationarity
of financial time series into SVMs. Unlike the standard SVMs which use a constant tube in all the training data points, the
ε-DSVMs use an adaptive tube to deal with the structure changes in the data. The experiment shows that the ε-DSVMs generalize
better than the standard SVMs in forecasting non-stationary financial time series. Another advantage of this modification
is that the ε-DSVMs converge to fewer support vectors, resulting in a sparser representation of the solution.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
Glycosylated amino acids and glycosylated human serum albumin reduce nitrite to nitric oxide under anaerobic conditions. The amount of nitric oxide produced was recorded by generation of nitrosoHb from deoxyHb. Without preincubation after the addition of sodium nitrite, glucose or a mixture of glucose with amino acid or serum albumin did not cause spectrophotometrically detectible transformation of deoxyHb into nitrosoHb. The generation of NO increased with an increase in content of colored "final" products of amino acid and serum albumin glycosylation in the incubation mixture. The incubation of blood plasma of patients with diabetes mellitus with nitrite also resulted in the increased production of NO as compared to blood plasma of healthy subjects. During the incubation of healthy subjects' blood plasma with nitrite a small amount of NO was produced. The removal of low-molecular-weight compounds was accompanied by a significantly decreased generation of NO by blood plasma. 相似文献
Diacylglycerol pyrophosphate (DGPP) is involved in a putative novel lipid signaling pathway. DGPP phosphatase (DGPP phosphohydrolase) is a membrane-associated 34-kDa enzyme from Saccharomyces cerevisiae which catalyzes the dephosphorylation of DGPP to yield phosphatidate (PA) and then catalyzes the dephosphorylation of PA to yield diacylglycerol. Amino acid sequence information derived from DGPP phosphatase was used to identify and isolate the DPP1 (diacylglycerol pyrophosphate phosphatase) gene encoding the enzyme. Multicopy plasmids containing the DPP1 gene directed a 10-fold overexpression of DGPP phosphatase activity in S. cerevisiae. The heterologous expression of the S. cerevisiae DPP1 gene in Sf-9 insect cells resulted in a 500-fold overexpression of DGPP phosphatase activity over that expressed in wild-type S. cerevisiae. DGPP phosphatase possesses a Mg2+-independent PA phosphatase activity, and its expression correlated with the overexpression of DGPP phosphatase activity in S. cerevisiae and in insect cells. DGPP phosphatase was predicted to be an integral membrane protein with six transmembrane-spanning domains. The enzyme contains a novel phosphatase sequence motif found in a superfamily of phosphatases. A dpp1Delta mutant was constructed by deletion of the chromosomal copy of the DPP1 gene. The dpp1Delta mutant was viable and did not exhibit any obvious growth defects. The mutant was devoid of DGPP phosphatase activity and accumulated (4-fold) DGPP. Analysis of the mutant showed that the DPP1 gene was not responsible for all of the Mg2+-independent PA phosphatase activity in S. cerevisiae. 相似文献