盖下坝水电站坝址区岩溶发育情况初步分析

盖下坝水电站工程为高山峡谷型电站,坝址区及附近岩石为碳酸盐岩,属中等坚硬易溶岩.岩溶发育是影响本工程库水外渗的重大工程地质问题之一.从施工开挖揭示的各种溶蚀现象中分析岩溶发育特征及其规律,为防渗设计提供依据.     

A chaotic non-dominated sorting genetic algorithm for the multi-objective automatic test task scheduling problem

Solving a task scheduling problem is a key challenge for automatic test technology to improve throughput, reduce test time, and operate the necessary instruments at their maximum capacity. Therefore, this paper attempts to solve the automatic test task scheduling problem (TTSP) with the objectives of minimizing the maximal test completion time (makespan) and the mean workload of the instruments. In this paper, the formal formulation and the constraints of the TTSP are established to describe this problem. Then, a new encoding method called the integrated encoding scheme (IES) is proposed. This encoding scheme is able to transform a combinatorial optimization problem into a continuous optimization problem, thus improving the encoding efficiency and reducing the complexity of the genetic manipulations. More importantly, because the TTSP has many local optima, a chaotic non-dominated sorting genetic algorithm (CNSGA) is presented to avoid becoming trapped in local optima and to obtain high quality solutions. This approach introduces a chaotic initial population, a crossover operator, and a mutation operator into the non-dominated sorting genetic algorithm II (NSGA-II) to enhance the local searching ability. Both the logistic map and the cat map are used to design the chaotic operators, and their performances are compared. To identify a good approach for hybridizing NSGA-II and chaos, and indicate the effectiveness of IES, several experiments are performed based on the following: (1) a small-scale TTSP and a large-scale TTSP in real-world applications and (2) a TTSP used in other research. Computational simulations and comparisons show that CNSGA improves the local searching ability and is suitable for solving the TTSP.     

浅谈网络办公自动化系统分析与设计

目前,网络办公自动化系统在企业日益普及。本文首先介绍了网络办公自动化系统分析,然后详细阐述了系统的设计,最后探讨了网络办公自动化系统主要模块功能。     

A collaborative filtering framework based on both local user similarity and global user similarity

Collaborative filtering as a classical method of information retrieval has been widely used in helping people to deal with information overload. In this paper, we introduce the concept of local user similarity and global user similarity, based on surprisal-based vector similarity and the application of the concept of maximin distance in graph theory. Surprisal-based vector similarity expresses the relationship between any two users based on the quantities of information (called surprisal) contained in their ratings. Global user similarity defines two users being similar if they can be connected through their locally similar neighbors. Based on both of Local User Similarity and Global User Similarity, we develop a collaborative filtering framework called LS&GS. An empirical study using the MovieLens dataset shows that our proposed framework outperforms other state-of-the-art collaborative filtering algorithms.     

一种面向数据结构的策略翻译技术

策略翻译是目前策略管理研究的难点之一.针对以数据结构表示的策略,提出策略结构五元组概念,增设可扩展的词库,采用XML语言统一描述策略结构,设计通用的脚本分析模块,支持不同设备类型的策略结构,实现透明的策略翻译,提高了策略管理的伸缩性、统一性和透明性.     

Ajax技术在教学论坛制作中的应用

当用户访问传统的ASP技术制作的论坛,并进行多种操作时,会多次重载页面或在不同页面间跳转。造成用户视觉上的不舒服以及花费较多的等待时间。采用Ajax技术可以很好的解决这样的问题,本文给出了用Ajax技术实现教学论坛部分功能的设计方法,使访问者获得更好的Web体验。     

幽门螺杆菌TNF-α诱导蛋白的生物信息学分析

肿瘤坏死因子诱导蛋白Tipα是幽门螺杆菌特有的一个膜相关蛋白.它可以激活核因子κB,并诱导多种细胞因子和趋化因子的表达,导致胃炎和随后的肿瘤发生.它是幽门螺杆菌和胃癌发生之间的关键分子.本文利用生物信息学工具分析Tipα序列,预测其信号肽、跨膜区、疏水性、二级结构、三级结构等性质.结果:Tipα具有一段信号肽、脂蛋白信号肽酶切位点及脂盒模体.另外该蛋白没有跨膜区,可能是一个外周膜蛋白.Tipα的三级结构说明,该蛋白形成了一个致密的球状结构,Tipα的二级结构以α螺旋为主.     

基于UML的医院门诊管理信息系统

UML是一种重要的面向对象软件开发方法,本文简述用UML进行系统建模的方法和步骤。以医院门诊管理信息系统为例,讲述如何利用UML对其进行需求分析、系统设计、实现及测试的具体过程。     

The Golden Touch by Light: A Finely Engineered Luminogen Empowering High Photoactivatable and Photodynamic Efficiency for Cancer Phototheranostics

Photoactivatable agent is a powerful tool in biomedicine studies due to high-precision spatiotemporal control of light. However, those previously reported agents generally suffer from short wavelength, fluorescence self-quenching effect, and the lack of photosensitizing property, which severely restrict their practical applications. To address these issues, molecular engineering of 1,4-dihydropyridine derivatives is conducted to obtain an optimized agent, namely TPA-DHPy-Py, which exhibits low oxidation potential, high photoactivation efficiency, and excellent type I/II combined photodynamic activity. Concurrently, its photoactivated counterpart is featured by aggregation-induced near-infrared emission and remarkable reactive oxygen species (ROS) production efficiency. Upon photoactivation, TPA-DHPy-Py is capable of precisely identifying cancer cells from co-culturing cancer cells and normal cells without the assistance of any extra targeting units, and in situ monitoring lipid droplets and endoplasmic reticulum alteration under ROS stress, as well as achieving fluorescent visualization of tumor in vivo with supremely high imaging contrast. Furthermore, the unprecedented performance on photodynamic cancer therapy is demonstrated by the significant inhibition of tumor growth. Therefore, the photoactivatable TPA-DHPy-Py with dual-organelle-targeted and excellent photodynamic activity associated with self-monitoring ability is highly promising for cancer theranostics in clinical trials.