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Mehrdad Hamrahian Karen T. Pitman Éva Csongrádi Justin H. Bain Béla Kanyicska Tibor Fülöp 《Hemodialysis international. International Symposium on Home Hemodialysis》2012,16(4):571-576
We are reporting on a series of two patients with end‐stage renal disease on hemodialysis, presented for surgical parathyroidectomy secondary refractory hyperparathyroidism. Both patients had failed maximized medical managements, including higher‐than‐usual doses of the calcimimetic cinacalcet (270 and 180 mg/day, respectively). On physical exam, both patients had marked symmetrical craniofacial hypertrophy with coarse distortion of facial features, similar in appearance to past reports of Sagliker syndrome. On X‐ray and computed tomographic exam, they had peculiar areas of bone absorption on the skull, imitating the radiologic appearance of multiple myeloma. Bone biopsy of the maxilla, however, did not show the expected brown tumor, but rather described only fibrosis and reactive bone formations. This phenotype developed while being on cinacalcet, progressed despite escalation of therapy, and improved only after parathyroidectomy. Both patients developed massive “hungry bone syndrome” after parathyroidectomy necessitating prolonged IV calcium infusion. This pattern of severe facial distortion likely represented an adverse consequence of severe tertiary hyperparathyroidism, along with supraphysiologic dose of cinacalcet administration and 25‐hydroxy vitamin D deficiency in sensitive individuals. The genetic base of this observation remained unexplained. 相似文献
13.
Tibor Bosse Mark Hoogendoorn Michel C. A. Klein Jan Treur C. Natalie van der Wal Arlette van Wissen 《Autonomous Agents and Multi-Agent Systems》2013,27(1):52-84
Collective decision making involves on the one hand individual mental states such as beliefs, emotions and intentions, and on the other hand interaction with others with possibly different mental states. Achieving a satisfactory common group decision on which all agree requires that such mental states are adapted to each other by social interaction. Recent developments in social neuroscience have revealed neural mechanisms by which such mutual adaptation can be realised. These mechanisms not only enable intentions to converge to an emerging common decision, but at the same time enable to achieve shared underlying individual beliefs and emotions. This paper presents a computational model for such processes. As an application of the model, an agent-based analysis was made of patterns in crowd behaviour, in particular to simulate a real-life incident that took place on May 4, 2010 in Amsterdam. From available video material and witness reports, useful empirical data were extracted. Similar patterns were achieved in simulations, whereby some of the parameters of the model were tuned to the case addressed, and most parameters were assigned default values. The results show the inclusion of contagion of belief, emotion, and intention states of agents results in better reproduction of the incident than non-inclusion. 相似文献
14.
Judit Olh Tibor Sznsi Attila Lehotzky Victor Norris Judit Ovdi 《International journal of molecular sciences》2022,23(3)
Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, however, the discovery of small molecules for use as drugs entails targeting individual proteins rather than targeting PPIs. This is largely because discovering small molecules to modulate PPIs has been seen as extremely challenging. Here, we review the difficulties and limitations of strategies to discover drugs that target PPIs directly or indirectly, taking as examples the disordered proteins involved in neurodegenerative diseases. 相似文献
15.
Acclimation to different temperatures by a poikilothermous animal must include modification of its membrane lipids to maintain
the proper physical properties. The simplest way to achieve this acclimation would seem to be by modification of the phospholipid
fatty acids. In a freshwater cray-fish,Procambarus clarkii, rapid changes in the degree of unsaturation of newly synthesized phospholipid fatty acids were correlated with changes in
environmental temperature, both in whole animals and in slices of hepatopancreas tissue. At 5 C, the rate of fatty acid synthesis
was about half that occurring at 23 C. Hepatopancreas tissue from animals acclimated to either 5 C or 23 C, when incubated
for 2 hr at 5 C, incorporated a higher percentage of exogenous [1-14C] acetate into polyunsaturated acids (27–38% of the radioactivity in total fatty acids) than when incubated at 23 C (12–14%);
conversely, more saturated fatty acids were synthesized at 23 C (73–80% vs 51–73%). The higher average unsaturation of the
fatty acids biosynthesized at 5 C constitutes an effective response to the animal's need for modification of lipids to maintain
adequate membrane function at the lower environmental temperature.
Presented at the AOCS meeting in Mexico City, Mexico, April 27–May 2, 1974.
Work done at the Laboratory of Nuclear Medicine and Radiation Biology, University of California, Los Angeles, CA 90024. 相似文献
16.
Freshly collectedCalanus pacificus were maintained in sea water containing 25 μCi/ml [32P]orthophosphate or 1 μCi/ml [14C]acetate at 10 C for 24 hr. The animals took up label from the environment and incorporated it into various lipid fractions.
After incubation with [14C]acetate the order of specific activity of the different lipid classes was: phospholipids > free fatty acids > wax esters
> triglycerides. Argentation thin layer chromatography of the fatty acid methyl esters showed that ca. 50% of the activity
was in saturated fatty acids and 34% in polyunsaturated acids. When the animals were exposed to [32P]orthophosphate, lysophosphatidyl choline became most heavily labeled, followed by lysophosphatidyl ethanolamine, sphingomyelin,
phosphatidyl ethanolamine, and phosphatidyl choline. Comparison of the data obtained with those available for decapods and
mammals revealed striking similarities between these phylogenetically distant groups. It is believed that labeling the lipids
of marine and freshwater planktonic crustaceans in this way will provide much information about the metabolism of lipids in
these organisms. 相似文献
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This study presents a novel application of marine geoelectromagnetic technique, in an attempt to delineate freshwater extension of the coastal sub-aquifers beneath the SE Mediterranean Sea, along central Israel. The novel marine Ex-Bz time domain electromagnetic (TDEM) geophysical method was applied, demonstrating high sensitivity to the presence of sub-seafloor electrically resistive structures up to several kilometers offshore (shallow marine environment). The study included 19 marine measurements located offshore between Ashdod in the south to Tel-Aviv in the north, where a previous onshore study detected fresh groundwater below seawater intrusion at the coast line. The offshore measurements were conducted to distances of up to 3 km from the shoreline. It was found that the lower sub-aquifer contains fresh groundwater (resistivity >10 Ω-m) to a distance of 2.8 km offshore along the 30 km strip, and is probably constrained by lateral geo-facial changes. 相似文献
19.
Abstract Fullerene Science and Technology, both the field and the journal, have observed considerable progress during the last few years. The field has continued to mature as witnessed by the many new and interesting results published in thousands of journal articles (1-3) and in a multitude of books and conference proceedings. The recognition of fullerene sciences as a self-containing field of research has been culminating in the awarding of the 1996 Chemistry Nobel Prize to Professors Robert S. Curl, Harold W. Kroto, and Richard E. Smailey. 相似文献
20.