ESD sensitivity of a GaAs MMIC microwave power amplifier

The EOS/ESD sensitivity of the main circuit blocks of a complete GaAs multi-stage power amplifier for microwave applications was investigated under HBM, MM and TLP regimes. Hard breakdown failure modes were identified due to passive components failure. The high current injection state of active components was also analyzed.     

A proposal toward the development of accessible e-learning content by human involvement

Most of the existing efforts for supporting the design, preparation, and deployment of accessible e-learning applications propose guidelines that primarily address technical accessibility issues. Little, if any, consideration is given to the real actors involved in the learning experience, such as didactical experts and disabled learners. Moreover, implementing artifacts addressed to the e-learning world requires a wide range of particular skills which are related not only to technical but also to didactical, pedagogical, usability, and accessibility aspects of the produced material. This paper argues that the know-how of a number of stakeholders should be blended into a joint design activity, and that it should be possible to determine the role of each participant in the successive phases of the development lifecycle of e-learning applications. The paper sketches the methodological guidelines of a design framework based on involving the users with disabilities, as well as pedagogical experts, in the development process. The novelty of this proposal mainly stems from being built up around the core of strategies and choices specifically bound to accessibility requirements. Characteristic elements of learner-centered design are then further integrated into processes and methodologies which are typical of participatory and contextual design approaches. Following such guidelines, it will be possible to gain a deeper understanding of the requirements and of the operational context of people needing accessible material, either as learners or educators. The underlying objective is to increase the potential to realize learning systems that better meet different user needs and that provide a more satisfying learning experience. Moreover, when people get involved in the development process, they gain a sense of ownership of the system and are therefore more likely to accept and “promote” it.     

Influence of Residual Impurities on Phase Partitiioning and Grain Growth Processes of Y-TZP Materials

Microstructural evolution at 1450°C of two 3 mol% Y₂O₃─ZrO₂ tetragonal polycrystals (Y-TZP) containing different residual impurity amounts has been investigated by analytical and scanning electron microscopy in order to clarify the role of the amorphous intergranular phases. Phase partitioning is interpreted as a process based on dissolution/reprecipitation reactions involving mass transport via the liquid impurity phase. Grain growth is inhibited by yttria migration before the phase equilibrium is reached, then increases drastically.     

The Electronic Tool Integration Platform as a Supplier and User of Graph Based Tools

ETI is an Electronic Tool Integration platform designed for project-oriented, domain-specific, public or private interactive experimentation with heterogeneous tools. Its users can experiment at ease over the web with the integrated tools and functionalities, and build own prototypical problem solvers on the basis of components (tools and transformations) contained in the ETI repository. In this paper we describe the graph concept underlying ETIs flexibility, the significant role played by graphs in the ETI platform, and the kind of support ETI offers to deal with graph objects. This way we sketch the potential of a closer cooperation between the ETI community and the community of research on graph-based tools.     

On Adaptive Density Deployment to Mitigate the Sink-Hole Problem in Mobile Sensor Networks

The use of mobile sensors is of great relevance to monitor critical areas where sensors cannot be deployed manually. The presence of data collector sinks causes increased energy depletion in their proximity, due to the higher relay load under multi-hop communication schemes (sink-hole phenomenon). We propose a new approach towards the solution of this problem by means of an autonomous deployment algorithm that guarantees the adaptation of the sensor density to the sink proximity and enables their selective activation. The proposed algorithm also permits a fault tolerant and self-healing deployment, and allows the realization of an integrated solution for deployment, dynamic relocation and selective sensor activation. We formally prove the termination of our algorithm. Performance comparisons between our proposal and previous approaches show how the former can efficiently reach a deployment at the desired variable density with moderate energy consumption under a wide range of operative settings.     

Persistent organochlorine compounds in fetal and maternal tissues: evaluation of their potential influence on several indicators of fetal growth and health

Some organochlorine compounds, such as polychlorinated biphenyls (PCBs), have a tendency to bioaccumulate in humans and predators at the top of the food chain. We have recently confirmed the transplacental transfer of these compounds and the present study has been designed on the same material with the aim of investigating their potential health effects on newborns from 70 pregnant women, resident in a Northern Italy industrial town. Organochlorine compounds [namely, p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT), p,p′-dichlorodiphenyldichloroethene (p,p′-DDE), hexachlorobenzene (HCB), and PCBs] have been analyzed both in cord and maternal serum, placenta, and maternal subcutaneous adipose tissue by GC-MSD. p,p′-DDT levels in the adipose tissue resulted significantly (p < 0.05) related to birth length. Mothers of neonates born by preterm programmed caesarean delivery showed significantly (p < 0.005 for both) higher serum p,p′-DDE serum concentrations and p,p′-DDT levels in the adipose tissue, as compared to mothers delivering at term.     

Dynamic and Formal Verification of Embedded Systems: A Comparative Survey

Embedded Systems, by their nature, constitute a meeting point for communities with extremely different background. In particular, the high demands for quality and reliability for embedded systems have led to complementary quality assurance efforts: hardware engineers have developed techniques for dynamic verification in terms of co-simulation, which, in particular, addresses the different nature of hardware and software components. Thus these techniques are tailored for the transactional level, which comprises dedicated models for the hardware and the software parts. On the other hand, there is a bulk of work on formal verification techniques, which typically address higher levels of abstraction. These techniques are exhaustive in the sense that they cover all the infinite possible paths of their models, however at the price of neglecting many of the low-level aspects treated by co-simulation. It is the goal of this paper to increase the mutual understanding between these communities and to animate research at this exciting borderline.     

Detection of Germline Variants in 450 Breast/Ovarian Cancer Families with a Multi-Gene Panel Including Coding and Regulatory Regions

With the progress of sequencing technologies, an ever-increasing number of variants of unknown functional and clinical significance (VUS) have been identified in both coding and non-coding regions of the main Breast Cancer (BC) predisposition genes. The aim of this study is to identify a mutational profile of coding and intron-exon junction regions of 12 moderate penetrance genes (ATM, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53) in a cohort of 450 Italian patients with Hereditary Breast/Ovarian Cancer Syndrome, wild type for germline mutation in BRCA1/2 genes. The analysis was extended to 5′UTR and 3′UTR of all the genes listed above and to the BRCA1 and BRCA2 known regulatory regions in a subset of 120 patients. The screening was performed through NGS target resequencing on the Illumina platform MiSeq. 8.7% of the patients analyzed is carriers of class 5/4 coding variants in the ATM (3.6%), BRIP1 (1.6%), CHEK2 (1.8%), PALB2 (0.7%), RAD51C (0.4%), RAD51D (0.4%), and TP53 (0.2%) genes, while variants of uncertain pathological significance (VUSs)/class 3 were identified in 9.1% of the samples. In intron-exon junctions and in regulatory regions, variants were detected respectively in 5.1% and in 32.5% of the cases analyzed. The average age of disease onset of 44.4 in non-coding variant carriers is absolutely similar to the average age of disease onset in coding variant carriers for each proband’s group with the same cancer type. Furthermore, there is not a statistically significant difference in the proportion of cases with a tumor onset under age of 40 between the two groups, but the presence of multiple non-coding variants in the same patient may affect the aggressiveness of the tumor and it is worth underlining that 25% of patients with an aggressive tumor are carriers of a PTEN 3′UTR-variant. This data provides initial information on how important it might be to extend mutational screening to the regulatory regions in clinical practice.     

Influence of microorganisms on retinol isomerization in milk

In order to have a deeper insight into the retinol isomerization phenomenon, in this work different milk samples have been analysed for their content of trans retinol and its cis-isomers, by means of reliable HPLC techniques. Levels of the different isomers and the degree of retinol isomerization (13-cis/all-trans ratio, %) have been monitored during milk storage at different temperatures and after addition of specific microorganisms. In raw milk stored at 4 degrees C for 96 h the degree of retinol isomerization shifted from 1.1 to 2.3%, while in raw milk stored at 22 degrees C for 24 h it increased from 1.1 to 12.7%. Among microorganisms tested in pasteurized milk, the most active in causing an increment in the 13-cis/all-trans ratio (%), from 3.4 to 33.4% in 8 h, was Streptococcus thermophilus. The results obtained demonstrated a relationship between microbial evolution and retinol isomerization. Therefore, the determination of retinol isomers is of importance not only for a more precise evaluation of vitamin A activity but also for the evaluation of the microbiological quality of milk.