Multiple Compression of Moist Spherical Elastic‐Plastic Zeolite 4A Granules

The compression, deformation and material behavior of moist spherical elastic‐plastic zeolite 4A granules under multiple stressing conditions at unique and random contacts were experimentally studied with the help of uniaxial diametrical compression tests. The force‐displacement curves were approximated and the coefficient of restitution was determined using appropriate mechanical models from literature. The phenomenon of cyclic hardening was studied and the critical number of cycles required to reach fracture was determined. Furthermore, the influence of particle size and moisture content on the material behavior at cyclic loading, the coefficient of restitution, and the critical number of cycles required to reach fracture were investigated.     

Influence of solvent and temperature on extraction of phenolic compounds from grape seed,antioxidant activity and colour of extract

This study was aimed to investigate the influence of solvent (water and ethanol in concentration: 50%, 70% and 96%) and extraction temperature (25–80) °C on polyphenols extraction of grape seed (Vitis vinifera L. cv. “Frankovka”) cultivated in Eastern Croatia. The best results were reached using 50% ethanol at 80 °C. The most abundant individual polyphenolic compound was catechin which makes the average of 45.11% of the total phenolic content followed by epicatechin (34.45%), procyanidin B₂ (12.90%), gallic acid (5.34%), gallocatechin (1.58%), epicatechin gallate (1.01%). The antioxidant activity of extracts was determined by DPPH‐method and it was highly dependent on extraction solvent and temperature. The total extractable proanthocyanidins content of extract had the highest positive correlation (r = 0.994) with antioxidant activity, which indicated that these compounds might be the most important antioxidant in examined grape seed extracts. Relationship between phenolic content and colour of extracts was observed.     

Fast radix-2 division with quotient-digit prediction

An implementation of a radix-2 division unit is presented that uses prediction of the quotient digit. This prediction allows the concurrent computation of the quotient digit and the partial remainder. To achieve a simple quotient-digit selection, resulting in a step time roughly half of that of SRT division (without prediction), a simple estimate of the partial remainder is used, which requires that the divisor be scaled close to unity. This prescaling is simple to implement and increases the execution time by two cycles. We estimate a speed-up of 1.5 with respect to SRT division with redundant remainders.     

Tribological behaviour of C-alloyed transition metal dichalcogenides (TMD) coatings in different environments

W-S-C films were deposited by non-reactive sputtering from a carbon target incrusted with WS₂ pellets in the eroded zone. This process allows depositing coatings with a wide range of compositions, with a precise control of their carbon content. Before the deposition, a Ti interlayer was interposed between the film and the substrate to improve the final adhesion. The carbon content in W-S-C system was varied from 29 at.% to 70 at.%, which led to an hardness enhancement from 4 GPa up to 10 GPa where the maximum hardness was reached in films with a carbon content between 40 at.% and 50 at.%. The tribological behaviour of the coatings was evaluated by pin-on-disk testing, in environments with different humidity levels. Generally, the tribological performance of W-S-C coatings in environments with moderate to high humidity is better for coatings with high carbon content. Friction coefficients, as 0.05 or lower could be reached at low humidity ranges (<7%) to all compositions. However, for higher humidity values, friction coefficient increased up to 0.30 in the W-S-C film with low carbon content whereas it was kept approximately constant for the others compositions.     

Guest Editorial

The extreme high speed of change in the area of information technology creates a new demand for a process of continues learning and relearning in the workplaces but also among the public as a whole. There is need for a deeper crossdisciplinary and interdisciplinary understanding of the effects of this extreme demand for learning and relearning, both on us as individuals, on public and private organization and on the society as a whole. Information technology provides to some extent possible solutions to the problems it creates. Consequently, web based learning is also expanding with an accelerating speed. But this new form of learning is not to the same extent backed up by a fast growing research, in areas like on-the job-learning, workplace pedagogics, 'competence ergonomics', etc. But there are a number of very good exceptions like the Knowledge Media Institute of the Open University, and also a number of newly established facilities like the network university in the north of Sweden, the Mid Sweden University. In this special issue these types of problems are discussed, including those where the emphasis lies in creating rational and effective methods for web-based training and learning. The following was put forward in the invitation to a particular target group for this special issue.     

Breakage behaviour of spherical granulates by compression

This paper describes the deformation and breakage behaviour of granulates in single particle compression test. Three industrial spherical granulates—γ-Al₂O₃, the synthetic zeolite Köstrolith^® and sodium benzoate (C₆H₅COONa) were used as model materials to study the mechanical behaviour from elastic to plastic range. The elastic compression behaviour of granulates is described by means of force-displacement curves, by application of Hertz-Huber contact theory and continuum mechanics. An elastic-plastic contact model was proposed to describe the deformation behaviour of elastic-plastic granules. The effects of granulate size and stressing velocity on the breakage force and contact stiffness during elastic and elastic-plastic displacement are examined. It is shown that the zeolite granulates with elastic-plastic behaviour have viscous properties as well. Breakage mechanisms of granulates during elastic, elastic-plastic and plastic deformation are also explained. The breakage probability is approximated by Weibull distribution function. The behaviour of the granulate during compression under the repeated loading-unloading conditions was investigated.     

Breakage probability of irregularly shaped particles

The investigation of breakage probability by compression of single particles was carried out. The spherical glass particles and irregularly shaped particles of NaCl, sugar, basalt and marble were subjected to a breakage test. The breakage test includes the compression up to breakage of 100 particles to obtain the distribution of the breakage probability depending on the breakage force or compression work. The breakage test was conducted for five particle size fractions from each individual material, at two stressing rates. Thus obtained 50 breakage force distributions and corresponding 50 breakage work distributions were fitted with log-normal distribution function.Usually, the breakage probability distribution can be found by means of stress or energy approach. The first one uses the stress to calculate the breakage probability distribution. The second approach uses the mass-related work done to break the particle. We prefer to use the breakage force and energy as essential variables. The correlation between the force and energy at their breakage points is obtained by integrating the characteristic force–displacement curve, i.e. the constitutive function of elastic–plastic mechanical behavior of the particle. The irregularly shaped particle is approximated by comparatively “large” hemispherical asperities. In terms of elastic–plastic deformation of the contacting asperities with the plate, a transition from elastic to inelastic deformation behavior was considered. Thus, one may apply the model of soft contact behavior of comparatively stiff hemispheres. Based on this model a relationship between the breakage force distributions and corresponding energy distributions was analyzed. Every tested material exhibits a linear relationship between average breakage energy and average breakage force calculated for every size fraction.For future consideration both force and energy distributions were normalized by division by average force or energy, consequently. The relationship between the fit parameters of normalized energy distribution and corresponding fit parameters of normalized force distribution was established. The mean value and standard deviation of normalized force distribution can be found from mean value and standard deviation of normalized energy distribution by means of system of two linear equations. The coefficients of those linear equations remain the same for all of the above tested materials; particle size fractions and stressing rates. As a result the simple transformation algorithm of distributions is developed. According to this algorithm the force distribution can be transformed into energy distribution and vice versa.     

An adsorptive transfer technique coupled with brdicka reaction to reveal the importance of metallothionein in chemotherapy with platinum based cytostatics

The drugs based on platinum metals represent one of the oldest, but also one of the most effective groups of chemotherapeutic agents. Thanks to many clinical studies it is known that resistance of tumor cells to drugs is a frequent cause of chemotherapy failure. With regard to platinum based drugs, multidrug resistance can also be connected with increased expression of low-molecular weight protein metallothionein (MT). This study aimed at investigating the interactions of MT with cisplatin or carboplatin, using the adsorptive transfer technique coupled with differential pulse voltammetry Brdicka reaction (AdTS DPV Brdicka reaction), and a comparison of in vitro results with results obtained in vivo. The results obtained from the in vitro study show a strong affinity between platinum based drugs and MT. Further, we analyzed extracts of neuroblastoma cell lines treated with cisplatin or carboplatin. It is clear that neuroblastoma UKF-NB-4 cisplatin-resistant and cisplatin-sensitive cell lines unlikely respond to the presence of the platinum-based cytostatics cisplatin and carboplatin. Finally, we determined the level of MT in samples from rabbits treated with carboplatin and patients with retinoblastoma treated with the same drug.     

Arylethyne Bromoboration–Negishi Coupling Route to E‐ or Z‐Aryl‐Substituted Trisubstituted Alkenes of ≥98% Isomeric Purity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes

The hitherto unprecedented palladium‐catalyzed cross‐coupling of (Z)‐β‐bromo‐β‐arylethenylboranes can be made to proceed satisfactorily through (1) the use of highly catalytically active bis(tri‐tert‐butylphosphine)palladium or dichloro[N,N‐bis‐(2,6‐diisopropylphenyl)imidazol‐2‐yl](m‐chloropyridine)palladium and (2) conversion of the dibromoboryl group to the (pinacol)boryl group. Thus, a wide variety of carbon groups can be used to substitute bromine in ≥98% stereo‐ and regioselectivity, while suppressing the otherwise dominant β‐debromoboration. Together with the alkylethyne‐based protocols, the alkyne bromoboration–Negishi coupling tandem process has emerged as the most widely applicable and highly selective route to trisubstituted alkenes including those that are otherwise difficult to access.