Multilayer Protection with Availability Guarantees in Optical WDM Networks

Survivability is a key concern in modern network design. This paper investigates the problem of survivable dynamic connection provisioning in general telecom backbone networks, that are mesh structured. We assume differentiated services where connections may have different availability requirements, so they may be provisioned differently with protection (if needed) based on their availability requirements and current network state. The problem of effectively provisioning differentiated-service requests, that has been widely investigated for connections routed at the physical layer, assumes peculiar features if we consider sub-wavelength requests at the logical layer that have to be protected (or more generically, whose availability target has to be guaranteed), but also have to be groomed for an efficient use of network resources. An integrated multilayer approach is necessary that considers requirements and grooming of connections at the logical layer as well as their routing and availability at the physical layer. Joint availability-guaranteed routing and traffic grooming may lead to a negative interaction, since the objective of the first problem (guaranteeing a given level of availability to the connections) clashes with the objective of the other problem (minimizing resource consumption). For a multilayer WDM mesh network, we propose new multilayer routing strategies that perform effective availability-guaranteed grooming of sub-wavelength connections. These strategies jointly considers connection availability satisfaction and resource optimization and are developed under two different practical hypotheses: guaranteed target, i.e., a connection is routed only if its availability target is satisfied, and best-effort target, a connection is always routed and, when the availability target cannot be guaranteed, the path with the best possible availability is provisioned. Numerical results are reported and discussed for the two approaches mentioned above. In both cases, the results show high effectiveness of our provisioning strategy.     

Optical network design with mixed line rates

Future telecommunication networks employing optical wavelength-division multiplexing (WDM) are expected to be increasingly heterogeneous and support a wide variety of traffic demands. Based on the nature of the demands, it may be convenient to set up lightpaths on these networks with different bit rates. Then, the network design cost could be reduced because low-bit-rate services will need less grooming (i.e., less multiplexing with other low-bit-rate services onto high-capacity wavelengths) while high-bit-rate services can be accommodated on a wavelength itself. Future optical networks may support mixed line rates (say over 10/40/100 Gbps). Since a lightpath may travel a long distance, for high bit rates, the effect of the physical impairments along a lightpath may become very significant (leading to high bit-error rate (BER)); and the signal’s maximum transmission range, which depends on the bit rate, will become limited.In this study, we propose a novel, cost-effective approach to design a mixed-line-rate (MLR) network with transmission-range (TR) constraint. By intelligent assignment of channel rates to lightpaths, based on their TR constraint, the need for signal regeneration can be minimized, and a “transparent” optical network can be designed to support all-optical end-to-end lightpaths. The design problem is formulated as an integer linear program (ILP). A heuristic algorithm is also proposed. Our results show that, with mixed line rates and maximum transmission range constraints, one can design a cost-effective network.     

Dimensioning for in-band and out-of-band signalling protocols in OBS networks

Most of the previous works on optical burst switching (OBS) assume in their analysis that signalling does not affect network performance. It is analysed here, under which conditions the effect of signalling is actually negligible, taking into account the effect of signalling in the evaluation of burst discard probability. First, analytical models for two different signalling approaches in an OBS network are presented: `out-of-band? and `in-band? techniques. The impact of these two signalling strategies in terms of the probability of burst discard are evaluated, identifying the component of bursts discarded as a consequence of control message losses or of excessive signalling delay. A new method is also discussed, based on the previous models, to assign the correct amount of resources to the control plane. To verify the accuracy of the analytical results, these are compared with results based on discrete-event simulationns: results are found to be in a highly satisfactory agreement with simulations.     

Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: establishment of a glial cell line with a functional CD4 receptor

Adeno associated virus (AAV) is a non-pathogenic dependent parvovirus with a broad host range, capable of high levels of transduction and stable integration into the host cell genome. We have investigated the potential for using AAV as a vector for gene transfer into glial cells of the human fetal nervous system. Recombinant AAV vectors expression either the reporter gene beta-galactosidase or a human CD4 receptor were able to transduce both primary glial cells of the human fetal nervous system and an SV40 immortalized human fetal glial cell line (SVG). No difference in transduction efficiency was observed between the primary cells and the cell line which in both cases was as high as 95%. Stable transfectants of the glial cell line expressing the CD4 receptor were selected. An SVG/CD4 expressing line was then established. The presence of the CD4 receptor was confirmed by immunohistochemistry, Westerm immuno-blotting and flow cytometric analysis. The CD4 receptor was shown to be functional by infection of the SVG/CD4 cell line with the human immunodeficiency virus (HIV). Upon infection, the SVG/CD4 cells produced 20-fold higher levels of the HIV intracellular core antigen P24 than the CD4 negative parental cells and in addition formed syncytia. The use of AAV vectors should prove useful in biological investigations of human glial cells and offers promise as a means of ex vivo and in vivo gene delivery.     

WDM Network Design by ILP Models Based on Flow Aggregation

Planning and optimization of WDM networks has raised much interest among the research community in the last years. Integer linear programming (ILP) is the most used exact method to perform this task and many studies have been published concerning this issue. Unfortunately, many works have shown that, even for small networks, the ILP formulations can easily overwhelm the capabilities of today state-of-the-art computing facilities. So in this paper we focus our attention on ILP model computational efficiency in order to provide a more effective tool in view of direct planning or other benchmarking applications. Our formulation exploits flow aggregation and consists in a new ILP formulation that allows us to reach optimal solutions with less computational effort compared to other ILP approaches. This formulation applies to multifiber mesh networks with or without wavelength conversion. After presenting the formulation we discuss the results obtained in the optimization of case-study networks.     

CD4+ and CD8+ lymphocyte and cortisol response patterns in elderly and young males after methylprednisolone exposure

The elderly have impaired cellular immunity and are more predisposed to opportunistic infections after long term glucocorticoid treatment. No data, examining the response of lymphocyte subsets (CD4+, CD8+) under baseline conditions and after exposure to methylprednisolone in young and elderly males, are available. This crossover study examined lymphocyte subsets and cortisol response patterns in seven elderly males (66-82 years) and five young males (24-37 years) randomized into Phase I (24 hr baseline) and Phase II (10 mg intravenous dose of methylprednisolone). Whole blood samples were obtained at 0, 4, 8, 12 and 24 hr to determine total lymphocytes and CD4+ and CD8+ cells utilizing monoclonal antibodies and flow cytometry. The absolute number of lymphocyte subsets and the lymphocyte area under the time curve (AUC) were measured and a 12 and 24 hr lymphocyte response ratio (AUC Phase II divided by AUC Phase I) was determined. Serial plasma samples over 24 hours were collected to quantitate cortisol (Phase I) and methylprednisolone concurrent with cortisol (Phase II). Pharmacokinetic parameters were generated and the cortisol AUC was determined. The AUC values for lymphocytes and cortisol from Phase II quantitated the pharmacologic response to methylprednisolone exposure while Phase I data described the interpatient variability in these parameters. Diurnal patterns for lymphocytes and cortisol were noted in all subjects during Phase I. The mean CD4+ and CD8+ lymphocyte AUC from 0 to 24 hr during Phase I was significantly smaller for the elderly when compared to young men. However, after exposure to methylprednisolone, lymphopenia occurred in all subjects with a mean decline of 54% in the elderly and 60% (p = 0.44) in young subjects for the total lymphocyte count and returned to baseline by 8-12 hr. During Phase II, the CD4+ lymphocytes (72% decline in elderly; 70% in young; p = 0.71) demonstrated a more notable decline than CD8+ cells (44% decline in elderly; 52% in young; p = 0.31) with a nadir occurring between 4 to 6 hr for both subsets. The lymphocyte response ratio was not significantly different between groups for total, CD4+, and CD8+ cells at 12 hr or 24 hr determinations. A slower clearance of methylprednisolone was noted in the elderly (mean: 256 mL/hr/Kg) than in the young men (mean: 359 mL/hr/Kg; p < 0.05) during Phase II with no significant difference found between groups for volume of distribution, elimination rate constant or half-life. A significantly smaller cortisol suppression ratio [0.36+/-0.11 (elderly) versus 0.58+/-0.11 (young), p = 0.01] which indicates a more profound cortisol suppression was noted. A significant correlation of -0.61 (p < 0.05) between drug exposure (methylprednisolone AUC) and pharmacologic effect (cortisol suppression ratio) was noted for the combined data in the young and elderly males. During Phase I, the CD4+ and CD8+ lymphocyte AUC was significantly smaller in the elderly. A definite suppression pattern for total, CD4+ and CD8+ lymphocytes and cortisol was noted after methylprednisolone exposure in young and elderly males. An age-dependent suppression of cortisol during Phase II was noted but the degree of lymphopenia after drug exposure did not differ between the young and elderly group for any of the cell subsets. These data from healthy elderly provide a basis for further studies to assess immunologic and endocrinologic responses among elderly patients requiring chronic glucocorticoid therapy.     

A novel bandwidth allocation scheme for OTSS-enabled flex-grid intra-datacenter networks

Photonic Network Communications - Optical circuit switching networks have been recognized as a promising solution for inter-datacenter networks. However, for intra-datacenter networks, they may...     

Optical Network Design With Mixed Line Rates and Multiple Modulation Formats

With the growth of traffic volume and the emergence of various new applications, future telecom networks are expected to be increasingly heterogeneous with respect to applications supported and underlying technologies employed. To address this heterogeneity, it may be most cost effective to set up different lightpaths at different bit rates in such a backbone telecom mesh network employing optical wavelength-division multiplexing. This approach can be cost effective because low-bit-rate services will need less grooming (i.e., less multiplexing with other low-bit-rate services onto high-capacity wavelengths), while a high-bit-rate service can be accommodated directly on a wavelength itself. Optical networks with mixed line rates (MLRs), e.g., 10/40/100 Gb/s over different wavelength channels, are a new networking paradigm. The unregenerated reach of a lightpath depends on its line rate. So, the assignment of a line rate to a lightpath is a tradeoff between its capacity and transparent reach. Thus, based on their signal-quality constraints (threshold bit error rate), intelligent assignment of line rates to lightpaths can minimize the need for signal regeneration. This constraint on the transparent reach based on threshold signal quality can be relaxed by employing more advanced modulation formats, but with more investment. We propose a design method for MLR optical networks with transceivers employing different modulation formats. Our results demonstrate the tradeoff between a transceiver's cost and its optical reach in overall network design.      

Optical investigation of the fuel injector influence in a PFI spark ignition engine for two-wheel vehicles

This paper describes the results obtained in a port fuel injection spark-ignition (PFI SI) engine by optical diagnostics during the fuel injection and the combustion process. A research optical engine was equipped with the fuel injection system, the head and the exhaust device of a commercial 250 cc engine for scooters and small motorcycles. Two injectors were tested: standard 3-hole injector that equipped the real reference engine and a 12-hole injector. The intake manifold was modified to allow the visualization of the fuel injection using an endoscopic system coupled with CCD camera. Size and number of the fuel droplets were evaluated through an image processing procedure. The cycle resolved visualization and chemiluminescence allowed to follow the combustion process from the spark ignition to the exhaust phase. All the optical data were correlated with engine parameters and exhaust emissions. The effect of the fuel injector type on deposits formed by fuel accumulation and dripping on the intake valves steams and seats was investigated. In particular, the evolution of diffusion-controlled flames due to the fuel deposits burning was analyzed. These flames were principally located near the intake valves, and they persisted well after the normal combustion event. The consequences were the formation and emission of soot and unburned hydrocarbons. The multi-hole injector helped reducing wall wetting and deposit formation so that the emission characteristic can be improved. The use of 12-hole injector allowed a more homogeneous distribution for a lower time of fuel droplets in the intake manifold than the 3-hole injector. This study also investigated the detailed physical/chemical phenomena to figure out reasons for the improvement using optical measurements.     

On the effect of channel spacing,launch power,and regenerator placement on the design of mixed-line-rate optical networks

Due to the increasing heterogeneity and the growing volume of traffic, telecom backbone networks are going through significant innovations. Wavelength-division multiplexed (WDM) optical networks can now cost-effectively support the growing heterogeneity of traffic demands by having mixed line rates (MLR) over different wavelength channels.The coexistence of wavelength channels with different line rates, e.g., 10/40/100 Gbps, in the same fiber brings up various design issues: in this study, we focus on (1) choice of channel spacing; (2) choice of launch power; and (3) regenerator placement. Channel spacing affects the signal quality in terms of bit-error rate (BER), and hence affects the maximum reach of lightpaths, which is a function of line rates. Various approaches to set an opportunistic width of the channel spacing can be considered, viz., (i) uniform fixed channel spacing specified by the ITU-T grid (typically 50 GHz); (ii) different channel spacing for different line rates; or (iii) optimal value of channel spacing for all line rates that leads to minimum cost.The launch optical power of a signal is another important parameter that affects the network cost. Adjacent channels on different line rates, especially 10 Gbps and 100 Gbps, may exhibit serious degradation of signal quality and optical reach for both the channels due to cross-phase modulation (XPM) between them. Launch power plays a role in such a scenario as it governs the BER by affecting both the signal power and the noise power due to XPM. Moreover, intelligent choice of launch powers on different line rates can significantly reduce the number of regenerators required in the network. The tradeoff between placement of regenerators and choice of launch power is an important problem to address for MLR network design.In this work, we investigate the effects of channel spacing and launch optical power by evaluating the cost of a MLR network for different values of these parameters. We also study the interplay between regenerator placement and launch power. Our results show that (a) it is possible to identify optimal values of channel spacing for a minimum-cost MLR network design, and (b) controlling the power of 10 Gbps and 100 Gbps channels shows maximum sensitivity to the network cost.