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681.
    
Cyclen-peptide bioconjugates are usually prepared in multiple steps that require individual preparation and purification of the cyclic peptide and hydrophilic cyclen derivatives. An efficient strategy is discovered for peptide cyclization and functionalization toward lanthanide probe via three components intermolecular crosslinking on solid-phase peptide synthesis with high conversion yield. Multifunctionality can be conferred by introducing different modular parts or/and metal ions on the cyclen-embedded cyclopeptide. As a proof-of-concept, a luminescent Eu3+ complex and a Gd3+-based contrasting agent for in vitro optical imaging and in vivo magnetic resonance imaging, respectively, are demonstrated through utilizing this preparation of cyclen-embedded cyclic arginylglycylaspartic acid (RGD) peptide.  相似文献   
682.
    
The combined finite-discrete element method (FDEM) was originally developed for fracture and fragmentation of brittle materials, more specifically for cementitious and rock-like materials. In this work, a combination of a discrete crack and plastic deformation has been combined and applied to FDEM simulation of fracture. The deformation is described using a FDEM-specific mechanistic approach with plastic deformation being formulated in material embedded coordinate systems leading to multiplicative decomposition and plastic flow, that is, resolved in stretch space; this is combined with the FDEM fracture and fragmentation criteria. The result and main novelty of the present work is a robust framework for simulation of large strain solid deformation combined with a multiplicative decomposition-based model that simultaneously involves elasticity, plasticity, and fracture.  相似文献   
683.
功率分配用双定子永磁无刷电机设计与电磁特性分析   总被引:3,自引:0,他引:3  
介绍了一种混合动力汽车(HEVs)功率分配用双定子永磁无刷(DS-PMBL)电机内外定子绕组功率合理配置的设计方法,导出了电机的尺寸方程,设计并制造了一台额定功率为2.5kW的样机。基于二维有限元法对电机的反电动势、电感、定位力矩等电磁特性进行了计算和分析。样机实验结果验证了设计方法和理论分析的正确性,为该电机用作HEVs功率分配装置的进一步研究奠定了基础。  相似文献   
684.
    
Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed.  相似文献   
685.
    
Two new demodulate‐and‐forward schemes of multi‐relay cooperative diversity with switch‐and‐examine relaying (SER) are analyzed. To reduce relay usage and enhance bandwidth efficiency, the two new cooperative diversity schemes employ a switch‐based relay selection. The proposed schemes consume less communication resource than regular relaying schemes, such as the selection combining (SC) or maximal ratio combining (MRC) schemes that always use all relays, and also achieve better performance than distributed switch‐and‐stay schemes. In the first scheme, the decision statistic for relay usage and selection is based on the signal‐to‐noise ratio (SNR). In the second scheme, the log‐likelihood ratio (LLR) of received signals is used for the decision of relay usage and selection. With the two SER schemes, the bit error probability (BEP) of binary phase shift keying (BPSK) and the average number of used paths are derived and expressed in closed‐form for the independent and identically distributed (i.i.d.) Rayleigh fading channels. Numerical and simulation results are presented for performance illustrations. According to the numerical results, the LLR‐based SER not only achieves a lower BEP but also consumes less relay resource than the SNR‐based SER. Furthermore, the LLR‐based SER scheme even outperforms the corresponding SNR‐based SC scheme for a range of average SNR. Copyright © 2014 John Wiley & Sons, Ltd.  相似文献   
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Pneumatic cylinders are one kind of low cost actuation sources which have been applied in industrial and robotics field, since they have a high power/weight ratio, a high-tension force and a long durability. To overcome the shortcomings of conventional pneumatic cylinders, a number of newer pneumatic actuators have been developed such as McKibben Muscle, Rubber Actuator and Pneumatic Artificial Muscle (PAM) Manipulators. However, some limitations still exist, such as the air compressibility and the lack of damping ability of the actuator bring the dynamic delay of the pressure response and cause the oscillatory motion. In addition, the nonlinearities in the PAM manipulator still limit the controllability. Therefore, it is not easy to realize motion with high accuracy and high speed and with respect to various external inertia loads. To overcome these problems, a novel controller which harmonizes a phase plane switching control method (PPSC) with conventional PID controller and the adaptabilities of neural network is newly proposed. In order to realize satisfactory control performance a variable damper, Magneto-Rheological Brake (MRB), is equipped to the joint of the robot. The mixture of conventional PID controller and an intelligent phase plane switching control using neural network (IPPSC) brings us a novel controller. The experiments were carried out in a robot arm, which is driven by two PAM actuators, and the effectiveness of the proposed control algorithm was demonstrated through experiments, which had proved that the stability of the manipulator can be improved greatly in a high gain control by using MRB with 1PPSC and without regard for the changes of external inertia loads.  相似文献   
690.
The adsorption of NO on Au 3D hemispherical crystals (field emitter tips) has been studied by means of pulsed field desorption mass spectrometry (PFDMS) under dynamic gas flow conditions and at 300 K. Local chemical probing of ~200 Au sites in the stepped surface region between the central (111) pole and the peripheral (001) plane leads to the detection of NO+, N2O+ and (NO) species. Obviously, molecular NO adsorption on stepped Au surfaces can lead to dimerization. Nitrous oxide formation probably occurs via the dimer, (NO)2.  相似文献   
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