Effects of intrathecal alpha1- and alpha2-noradrenergic agonists and norepinephrine on locomotion in chronic spinal cats

Noradrenergic drugs, acting on alpha adrenoceptors, have been found to play an important role in the initiation and modulation of locomotor pattern in adult cats after spinal cord transection. There are at least two subtypes of alpha adrenoceptors, alpha1 and alpha2 adrenoceptors. The aim of this study was to investigate the effects of selective alpha1 and alpha2 agonists in the initiation and modulation of locomotion in adult chronic cats in the early and late stages after complete transection at T13. Five cats, chronically implanted with an intrathecal cannula and electromyographic (EMG) electrodes were used in this study. Noradrenergic drugs including alpha2 agonists (clonidine, tizanidine, and oxymetazoline) and an antagonist, yohimbine, one alpha1 agonist (methoxamine), and a blocker, prazosin, as well as norepinephrine were injected intrathecally. EMG activity synchronized to video images of the hindlimbs were recorded before and after each drug injection. The results show differential effects of alpha1 and alpha2 agonists in the initiation of locomotion in early spinal cats (i.e., in the first week or so when there is no spontaneous locomotion) and in the modulation of locomotion and cutaneous reflexes in the late-spinal cats (i.e., when cats have recovered spontaneous locomotion). In early spinal cats, all three alpha2 agonists were found to initiate locomotion, although their action had a different time course. The alpha1 agonist methoxamine induced bouts of nice locomotor activity in three spinal cats some hours after injection but only induced sustained locomotion in one cat in which the effects were blocked by the alpha1 antagonist prazosin. In late spinal cats, although alpha2 agonists markedly increased the cycle duration and flexor muscle burst duration and decreased the weight support or extensor activity (effects blocked by an alpha2 antagonist, yohimbine), alpha1 agonist increased the weight support and primarily the extensor activity of the hindlimbs without markedly changing the timing of the step cycle. Although alpha2 agonists, especially clonidine, markedly reduced the cutaneous excitability and augmented the foot drag, the alpha1 agonist was found to increase the cutaneous reflex excitability. This is in line with previously reported differential effects of activation of the two receptors on motoneuron excitability and reflex transmission. Noradrenaline, the neurotransmitter itself, increased the cycle duration and at the same time retained the cutaneous excitability, thus exerting both alpha1 and alpha2 effects. This work therefore suggests that different subclasses of noradrenergic drugs could be used to more specifically target aspects of locomotor deficits in patients after spinal injury or diseases.     

High-/spl kappa//metal-gate stack and its MOSFET characteristics

We show experimental evidence of surface phonon scattering in the high-/spl kappa/ dielectric being the primary cause of channel electron mobility degradation. Next, we show that midgap TiN metal-gate electrode is effective in screening phonon scattering in the high-/spl kappa/ dielectric from coupling to the channel under inversion conditions, resulting in improved channel electron mobility. We then show that other metal-gate electrodes, such as the ones with n+ and p+ work functions, are also effective in improving channel mobilities to close to those of the conventional SiO/sub 2//poly-Si stack. Finally, we demonstrate this mobility degradation recovery translates directly into high drive performance on high-/spl kappa//metal-gate CMOS transistors with desirable threshold voltages.     

Is activity-based working impacting health,work performance and perceptions? A systematic review

ABSTRACT

Numerous claims have been made about the benefits of activity-based working (ABW) on workers’ health and work performance. Yet, it is unclear if these claims are proven. This systematic review aims to establish whether there is an evidence base for the effects of ABW on health, work performance and perceptions of the work environment. Eight databases were searched in September 2016. Three reviewers independently screened titles and abstracts and assessed the studies and extracted the data. Seventeen studies involving 36,039 participants were included. The study designs varied in rigorousness from qualitative studies to pre–post-trials and in sample size ranging from 12 to 11,799. This review found that ABW has positive merits in the areas of interaction, communication, control of time and space, and satisfaction with the workspace; however, it is unfavourable for concentration and privacy. For physical and mental health, the evidence is equivocal. ABW seems to be a promising concept that can be implemented and promoted based on some benefits for work performance and perceptions of the work environment when it is coupled with appropriate management support and organization. More high-quality research is needed to strengthen the evidence base further and establish its health effects.     

Variational estimates of the effective thermal conductivities of transversely isotropic composites

A study is made of a type of composite material that is widely used in practical applications — a composite with fibers of constant cross section arranged parallel to one another in the matrix. The effective thermal conductivities of transversely Isotropie composites is estimated on the basis of dual variational principles from thermostatics. Certain geometric models that are of practical interest are examined and refined estimates of their effective conductivities are obtained. Due to mathematical equivalence, the results obtained can also be used for effective electrical conductivity, the effective diffusion coefficient, effective permittivity, and effective permeability.Translated from Inzhenerno-fizicheskii Zhurnal, Vol. 59, No. 10, pp. 562–568, October, 1990.     

pH-independent dissolution enhancement for multiple poorly water-soluble drugs by nano-sized solid dispersions based on hydrophobic–hydrophilic conjugates

The objective of this study was to achieve an optimal formulation of hydrophilic–hydrophobic conjugates for nano-sized solid dispersions (SDs) with enhanced dissolution of multiple drugs in different gastrointestinal (GI) tract environments. A new conjugate powder with an optimized process was used to fabricate SDs that contained three poorly water-soluble drugs that were also poorly soluble in different dissolution media. The self-assembled nanoparticle formation, drug crystallinity and SD molecular interactions were investigated by measuring the particle size during dissolution testing and physicochemical property analysis (powder X-ray diffraction and Fourier transform infrared spectroscopy). Drug release studies indicated that SD containing conjugated powder significantly improved the dissolution rates of these poorly water-soluble drugs in the GI tract. In addition, particle size analysis showed nano-sized particles in the dissolution media in the early stage with a tendency to reduce smaller particles over time. Physicochemical characterizations demonstrated almost amorphous drug states and hydrogen bonding interactions between the drugs and conjugates in the SD. This study optimized a promising material for SD, and the material was shown to have a promising performance under various pH medium conditions with poorly water-soluble drugs.     

A choice experiment to estimate the effect of green experience on preferences and willingness-to-pay for green building attributes

As the number and complexities of green building developments are mainly driven by market demands, understanding of end-user behaviors towards their development eventually should play a crucial role on determining their successes. However, very few studies have been attempted to explore end-user behaviors towards green building development. This study successfully applied discrete choice experiments to reveal whether residents with green experience will have different preference and willingness-to-pay values for enhancements on various aspects of environmental performance in green buildings. Generally, both green and conventional residents had strong preferences and were willing to pay more for improving various aspects of environmental performance in green residential developments. They are found to be willing to pay more for energy conservation, than indoor air quality improvement, noise level reduction, landscape area enlargement, or water conservation. No significant differences are found in the preferences between green and conventional residents for energy conservation, indoor air quality improvement, indoor noise reduction, or water conservation, However, green residents were found to be willing to pay significantly less than the conventional residents for enlarging the landscape area within a residential development, despite it was perceived by green residents as one of the major elements that differentiate a green from a conventional development.     

The Economical PAPR Minization Scheme for Combinative Coding Technique Applied OFDM Communication System

In this paper, we propose a new combinative scheme to combine with parity check and block coding methods for the reduction of the peak to average power ratio (PAPR) of orthogonal frequency division multiplexing (OFDM) system. In the proposed schemes, the simulation results shown that Peak-to-Average Power Ratio (PAPR) can be reduced by 3.502 dB. The results of this mapped can be shown that PAPR is reduced. The principle of the scheme is illustrated with the specific example of an eight-carriers signal and its computer simulation results. All simulation results have compare with ideal channel case and AWGN case separately; both of cases are shown the PAPR reduced indeed. Do Horng Guo received his B.S. Degree in Electronic Engineering from National Taiwan Marine Science University, Keelung, Taiwan, in 1983, and M.S. Degree in Computer Communication from Northrop University, Los Angeles, USA, in 1986. He is enrolled in Ph.D program in Graduate Institute of Communication Engineering of Tatung University from 2001. His current interest includes wireless communication system and digital signal processing. Chau-Yun Hsu received his B.S. degree M.S. and Ph.D in Electrical Engineering from Tatung Institute of Technology, Taipei, Taiwan, in 1981, 1983 and 1988, respectively. He was the lecturer in Department of Electrical Engineering of Tatung University from 1983 to 1985. From 1988 to 1997, he served as the Associate professor of Tatung University. Since 1998, he has been the Chair Professor of Graduate Institute of Communication Engineering of Tatung University. Now he is also the chair of department of Electrical Engineering of Tatung University. His current interest includes Wireless Channel Model and Estimation, Machine Learning, Digital Signal Processing and Image Processing.