Tamoxifen downregulates TGF-beta production in keloid fibroblasts

BACKGROUND: It has recently been suggested that primary lactase deficiency might have been selected for by malaria, as occurred for beta-thalassaemia and glucose 6-phosphate dehydrogenase deficiency. However, recently we have found that the prevalence of primary lactase deficiency in the area of Sassari (Northern Sardinia), where, in the past, there was intermediate malarial endemicity, is comparable to that observed in the adult population from other areas of Southern Italy where malaria was less endemic. AIMS: To address the problem further, we have determined the prevalence of primary lactase deficiency, glucose 6-phosphate dehydrogenase deficiency deficiency and beta-thalassaemia trait in the populations of three Sardinian villages which differ in altitude above sea-level, socioeconomic features, history of endemic malaria and prevalence of b-thalassaemia and glucose 6-phosphate dehydrogenase deficiency. SUBJECTS: We tested 138 adult males: 53 were from Fonni (a non-malarial mountain village, with a strong pastoral tradition), 38 from Lodé (a village with a similar pastoral tradition, but high malarial endemicity in the past) and 47 from Terralba (a lowland fishing village with an agricultural tradition and heavy malarial morbidity and mortality). METHODS: A blood sample was obtained in all subjects for determination of HbA2 and glucose 6-phosphate dehydrogenase activity. Lactase deficiency was assessed by measuring breath hydrogen production after oral administration of lactose (50 g), by gas-chromatography. RESULTS: The frequencies of glucose 6-phosphate dehydrogenase deficiency and of beta-thalassaemia trait in the non-malarial village of Fonni were strikingly low, compared to frequencies found in the two villages (Terralba and Lodé) with a very high past malarial morbidity. In contrast, there was no significant difference in the prevalence of lactase deficiency in the three groups of subjects from the three villages. CONCLUSIONS: These data obtained in Northern Sardinia do not support the hypothesis of a selection of primary lactase deficiency by malaria. For definitive conclusions, however, the malaria hypothesis should be tested in other parts of the world.     

Effects of intrathecal alpha1- and alpha2-noradrenergic agonists and norepinephrine on locomotion in chronic spinal cats

Noradrenergic drugs, acting on alpha adrenoceptors, have been found to play an important role in the initiation and modulation of locomotor pattern in adult cats after spinal cord transection. There are at least two subtypes of alpha adrenoceptors, alpha1 and alpha2 adrenoceptors. The aim of this study was to investigate the effects of selective alpha1 and alpha2 agonists in the initiation and modulation of locomotion in adult chronic cats in the early and late stages after complete transection at T13. Five cats, chronically implanted with an intrathecal cannula and electromyographic (EMG) electrodes were used in this study. Noradrenergic drugs including alpha2 agonists (clonidine, tizanidine, and oxymetazoline) and an antagonist, yohimbine, one alpha1 agonist (methoxamine), and a blocker, prazosin, as well as norepinephrine were injected intrathecally. EMG activity synchronized to video images of the hindlimbs were recorded before and after each drug injection. The results show differential effects of alpha1 and alpha2 agonists in the initiation of locomotion in early spinal cats (i.e., in the first week or so when there is no spontaneous locomotion) and in the modulation of locomotion and cutaneous reflexes in the late-spinal cats (i.e., when cats have recovered spontaneous locomotion). In early spinal cats, all three alpha2 agonists were found to initiate locomotion, although their action had a different time course. The alpha1 agonist methoxamine induced bouts of nice locomotor activity in three spinal cats some hours after injection but only induced sustained locomotion in one cat in which the effects were blocked by the alpha1 antagonist prazosin. In late spinal cats, although alpha2 agonists markedly increased the cycle duration and flexor muscle burst duration and decreased the weight support or extensor activity (effects blocked by an alpha2 antagonist, yohimbine), alpha1 agonist increased the weight support and primarily the extensor activity of the hindlimbs without markedly changing the timing of the step cycle. Although alpha2 agonists, especially clonidine, markedly reduced the cutaneous excitability and augmented the foot drag, the alpha1 agonist was found to increase the cutaneous reflex excitability. This is in line with previously reported differential effects of activation of the two receptors on motoneuron excitability and reflex transmission. Noradrenaline, the neurotransmitter itself, increased the cycle duration and at the same time retained the cutaneous excitability, thus exerting both alpha1 and alpha2 effects. This work therefore suggests that different subclasses of noradrenergic drugs could be used to more specifically target aspects of locomotor deficits in patients after spinal injury or diseases.     

Generalized nonlinear FET/HEMT modeling

A modeling procedure which provides an accurate large-signal response for variation in bias, input power level, and fundamental frequency for FET/HEMT transistors is designed. A procedure for measuring the large-signal input response on an easily implemented system is presented. The technique is illustrated by designing a nonlinear PHEMT model, which includes an accurate large-signal input response and works with variations in the aforementioned input conditions. © 2004 Wiley Periodicals, Inc. Int J RF and Microwave CAE 14, 122–133, 2004.     

Energy conservation in compressed‐air systems

In this paper, we evaluate and quantify the energy losses associated with compressed‐air systems, and their costs to manufacturers. We also show how to reduce the cost of compressed air in existing facilities by making some modifications with attractive payback periods. Among the measures, we investigate to reduce the compressed air are: (1) repairing air leaks, (2) installing high‐efficiency motors, (3) reducing the average air inlet temperature by using outside air (4) reducing compressor air pressure. We also illustrate the potential saving associated with each measure by using realistic examples. Copyright © 2002 John Wiley & Sons, Ltd.     

High-/spl kappa//metal-gate stack and its MOSFET characteristics

We show experimental evidence of surface phonon scattering in the high-/spl kappa/ dielectric being the primary cause of channel electron mobility degradation. Next, we show that midgap TiN metal-gate electrode is effective in screening phonon scattering in the high-/spl kappa/ dielectric from coupling to the channel under inversion conditions, resulting in improved channel electron mobility. We then show that other metal-gate electrodes, such as the ones with n+ and p+ work functions, are also effective in improving channel mobilities to close to those of the conventional SiO/sub 2//poly-Si stack. Finally, we demonstrate this mobility degradation recovery translates directly into high drive performance on high-/spl kappa//metal-gate CMOS transistors with desirable threshold voltages.     

On line fatiguemeter: a large experiment in French nuclear plants

During operation of PWR plants, thermal transients occur and induce fatigue stresses at critical locations in the nuclear steam supply system. Assessment of cumulative usage factor at these locations is one the major concerns regarding plant life extension.A system based on real time fatigue monitoring his been developed by EDF. The principle of the system, that records plant operating parameters and calculate thermohydraulic conditions, local stresses and usage factor resulting from each individual transient, is firstly presented.Demonstration experiments, concerning two higly stressed locations of reactor coolant system (charging line nozzle and surge line), carried out in two 900 MW units are then described.Finally, analysis of these experiment results is commented. The system allows automatic transients book keeping and usage factor assessment. EDF intends to equip all its PWR units with such fatigue monitoring systems.     

Novel permanent magnet motor drives for electric vehicles

Novel permanent magnet (PM) motor drives have been successfully developed to fulfil the special requirements for electric vehicles such as high power density, high efficiency, high starting torque, and high cruising speed. These PM motors are all brushless and consist of various types, namely rectangular-fed, sinusoidal-fed, surface-magnet, buried-magnet, and hybrid. The advent of novel motor configurations lies on the unique electromagnetic topology, including the concept of multipole magnetic circuit and full slot-pitch coil span arrangements, leading to a reduction in both magnetic yoke and copper, decoupling of each phase flux path, and hence an increase in both power density and efficiency. Moreover, with the use of fractional number of slots per pole per phase, the cogging torque can be eliminated. On the other hand, by employing the claw-type rotor structure and fixing an additional field winding as the inner stator, these PM hybrid motors can further provide excellent controllability and improve efficiency map. In the PM motors, by purposely making use of the transformer EMF to prevent the current regulator from saturation, a novel control approach is developed to allow for attaining high-speed constant-power operation which is particularly essential for electric vehicles during cruising. Their design philosophy, control strategy, theoretical analysis, computer simulation, experimental tests and application to electric vehicles are described     

Spectral analysis of a new six-phase pole-changing induction motor drive for electric vehicles

In this paper, a new six-phase pole-changing induction motor drive is proposed to extend the constant-power operating range for electric vehicle application. The double Fourier series is newly employed to analyze the spectra of the motor phase voltage and current. Consequently, the harmonic expression of the inverter DC-link current can be derived. In order to reduce the DC-link harmonics, a new sinusoidal pulsewidth-modulation strategy is developed for the proposed six-phase inverter. Experimental results, particularly the spectra of the phase current and the DC-link current, are given to verify the theoretical analysis.     

High-speed InP/InGaAs heterojunction bipolar transistors

Very-high-performance common-emitter InP/InGaAs single heterojunction bipolar transistors (HBTs) grown by metalorganic molecular beam epitaxy (MOMBE) are reported. They exhibit a maximum oscillation frequency (f_T) of 180 GHz at a current density of 1×10⁵ A/cm². this corresponds to an (R_BC_BC)_eff=f _T/(8πf²_max) delay time of 0.12 ps, which is the smallest value every reported for common-emitter InP/InGaAs HBTs. The devices have 11 μm² total emitter area and exhibit current gain values up to 100 at zero base-collector bias voltage. The breakdown voltage of these devices is high with measured BV_CEO and BV_CEO of 8 and 17 V, respectively     

Fracture of shear bands in atactic polystyrene

Thick shear bands in polystyrene formed by compression could cause fracture or the formation of cracks by intersecting with themselves, by relaxing after the removal of the load, by propagating all the way to the side surfaces and by subsequent tensile deformation. The microstructural mechanisms involved in all these fracture processes are discussed.