潜山内幕油藏裂缝发育段井眼信息响应特征研究

裂缝发育段是潜山内幕油藏主要储集空间。辽河油田在兴隆台潜山内幕油藏勘探开发实践中,注重挖掘裂缝发育段的井眼信息响应特征以及各种信息间的匹配关系,认识到裂缝发育段在钻井过程中钻井液易漏失,录井显示级别高、气测异常明显、地球化学录井与轻烃录井含油指标突出,测井信息特征明显,且不同信息之间表现出较好的耦合关系,大大提高了裂缝发育段识别的准确性。为投产选择射孔层段、储量计算中有效厚度的合理划分、潜山内幕油藏立体开发模式的建立提供了可靠的地质基础。有效指导了辽河油田潜山内幕油藏的勘探开发工作,实现了兴隆台潜山亿吨级规模储量的快速探明和百万吨年产能力快速建成,以及油藏的有效开发、高效开发。     

RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist

The 5-HT2C receptor is one of three closely related receptor subtypes in the 5-HT2 receptor family. 5-HT2A and 5-HT2B selective antagonists have been described. However, no 5-HT2C selective antagonists have yet been disclosed. As part of an effort to further explore the function of 5-HT2C receptors, we have developed a selective 5-HT2C receptor antagonist, RS-102221 (a benzenesulfonamide of 8-[5-(5-amino-2,4-dimethoxyphenyl) 5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione). This compound exhibited nanomolar affinity for human (pKi = 8.4) and rat (pKi = 8.5) 5-HT2C receptors. The compound also demonstrated nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 acted as an antagonist in a cell-based microphysiometry functional assay (pA2 = 8.1) and had no detectable intrinsic efficacy. Consistent with its action as a 5-HT2C receptor antagonist, daily dosing with RS-102221 (2 mg/kg intraperitoneal) increased food-intake and weight-gain in rats. Surprisingly, RS-102221 failed to reverse the hypolocomotion induced by the 5-HT2 receptor agonist 1-(3-chlorophenyl)piperazine (m-CPP). It is concluded that RS-102221 is the first selective, high affinity 5-HT2C receptor antagonist to be described.     

Surface-enhanced Raman scattering nanosensors for <Emphasis Type="Italic">in vivo</Emphasis> detection of nucleic acid targets in a large animal model

Although nanotechnology has led to important advances in in vitro diagnostics, the development of nanosensors for in vivo detection remains very challenging. Here, we demonstrated the proof-of-principle of in vivo detection of nucleic acid targets using a promising type of surface-enhanced Raman scattering (SERS) nanosensor implanted in the skin of a large animal model (pig). The in vivo nanosensor used in this study involves the “inverse molecular sentinel” detection scheme using plasmonics-active nanostars, which have tunable absorption bands in the near infrared region of the “tissue optical window”, rendering them efficient as an optical sensing platform for in vivo optical detection. Ex vivo measurements were also performed using human skin grafts to demonstrate the detection of SERS nanosensors through tissue. In this study, a new core–shell nanorattle probe with Raman reporters trapped between the core and shell was utilized as an internal standard system for self-calibration. These results illustrate the usefulness and translational potential of the SERS nanosensor for in vivo biosensing.

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Deformation behavior of styrene-block-butadiene-block-styrene triblock copolymers having different morphologies

Deformation behavior of styrene-block-butadiene-block-styrene (SBS) triblock copolymers having different morphologies was investigated. Due to the combination of different methods which provide information on different deformation levels (macroscopic, microscopic and molecular) complex deformation mechanisms for each type of SBS block copolymer (including glassy-rubber alternating lamellae, rubber cylinders in glassy matrix and hard domains in soft matrix morphology) could be revealed. In combination with tensile tests, Fourier transform infrared (FTIR) spectroscopy was successfully applied to study the change of orientation in individual phases using the absorption bands at 1493 and 966 cm⁻¹ for polystyrene (PS) and polybutadiene (PB) phases, respectively. For all the block copolymers investigated the PB phase always oriented stronger than the PS phase because of its lower Young's modulus. However, differences in orientation in both phases were influenced by an appropriate stress distribution within the specimens during deformation, which, in fact, depends on the morphology of the polymers. Additionally, atomic force microscopy revealed local morphological changes during uniaxial stretching, which, in fact, depend on the arrangement of the structural units.     

一种新型光纤光栅波长与带宽独立调谐的方法

提出了一种新型的光纤光栅的中心波长与带宽独立调谐的方法。将光纤布拉格光栅(FBG)粘贴于圆环形薄壁截面梁的外表面,通过旋转圆环形薄壁截面梁,即相当于改变光纤光栅的位置来实现中心波长与带宽的独立调谐。实验上得到了6.706 nm准无啁啾的中心波长调谐和5.368 nm的准无中心波长漂移的最大带宽调谐,并且此中心波长和带宽调谐均与拉力呈线性关系,实验结果与理论分析一致。     

基于遗传算法和结构误差的平面四杆机构轨迹优化综合

提出了基于结构误差进行平面四杆机构轨迹优化综合的方法。基于结构误差建立了一个统一的优化综合模型 ,使连杆轨迹曲线上的点与原动件的运动可以相关也可以不相关 ,采用改进的遗传算法进行优化计算 ,保证了获得全局最优解。该优化综合模型应用与机构分析相同的解析函数方法来完成机构的轨迹综合 ,因此计算便利。给出了三个综合实例 :与原动件运动不相关的直线轨迹和直角轨迹、与原动件运动相关的 8字形轨迹 ,结果表明了本方法的有效性     

Multi-functional biochip for medical diagnostics and pathogen detection

We describe a multi-functional biochip (MFB), which uses two different types of bioreceptors, including nucleic acid and antibody probes, on a single platform. The multi-functional capability of the MFB device for biomedical diagnostics is illustrated by measurements of DNA probes specific to gene fragments of Bacillus anthracis and antibody probes targeted to Escherichia coli. Calibration curves for monitoring pathogenic species using antibody probes against E. coli and DNA probes for B. anthracis illustrate the capability of the device for medical diagnostics and for quantitative detection of pathogenic agents.     

Design and Fabrication of Fiber-Optic Nanoprobes for Optical Sensing

This paper describes the design and fabrication of fiber-optic nanoprobes developed for optical detection in single living cells. It is critical to fabricate probes with well-controlled nanoapertures for optimized spatial resolution and optical transmission. The detection sensitivity of fiber-optic nanoprobe depends mainly on the extremely small excitation volume that is determined by the aperture sizes and penetration depths. We investigate the angle dependence of the aperture in shadow evaporation of the metal coating onto the tip wall. It was found that nanoaperture diameters of approximately 50 nm can be achieved using a 25° tilt angle. On the other hand, the aperture size is sensitive to the subtle change of the metal evaporation angle and could be blocked by irregular metal grains. Through focused ion beam (FIB) milling, optical nanoprobes with well-defined aperture size as small as 200 nm can be obtained. Finally, we illustrate the use of the nanoprobes by detecting a fluorescent species, benzo[a]pyrene tetrol (BPT), in single living cells. A quantitative estimation of the numbers of BPT molecules detected using fiber-optic nanoprobes for BPT solutions shows that the limit of detection was approximately 100 molecules.     

Wireless transmission of HD video using H.264 compression over UWB channel

With the technological advancement, entertainment has become revolutionized and the high-definition (HD) video has become an integral feature of our modern amusement system. The demand for wireless transmission of HD video is rapidly rising for its ubiquitous nature, easy installation and relocation. Such wireless transmissions of HD video streams require very high bandwidth. The ultra-wideband (UWB) offers a large bandwidth, and short-range high-speed data transmission at low cost and low power consumption. In this paper, we present the feasibility study to transmit HD video wirelessly using H.264/AVC compression over the UWB communication channel. Simulations are carried out by controlling key H.264/AVC encoder parameters such as, in-loop deblocking filter, group of pictures, and quantization parameter. Based on the analysis, an optimum setting of these parameters is proposed for different bandwidth requirements, as well as acceptable video quality. The bandwidth achieved is restricted between 1.5 and 20?Mbps with a minimum reconstruction quality of 34?dB. The HD bit stream is then transmitted over the UWB communication channel and the demonstration shows that the overall encoder performance is satisfactory with the transmission bit-error-rate (BER) in the range of 10^?5?C10^?8.