从集体利益中产生个人利益——共鸣设计方法及其在独立住宅转化为集合住宅中的运用

提出可以增加集合住宅受欢迎度的共鸣设计方法策略,这些策略不仅考虑到建筑本身的一些可能性,同时考虑到在空间和社会环境方面的要求,涵盖了物理的、心理的以及社会的因素;指出这类策略的应用带来了高度的用户接受度并使得适应性建筑在一个长时期内可以保持其价值.阐释在设计方法的帮助下,建筑物被记录和相互比较.     

A rigorous small area modelling-study for the helicobacter pylori epidemiology

This paper presents an investigation into spatial risk differences over small distances for the Helicobacter pylori infection in the city of Leipzig, Germany and two rural districts. A model, using Bayesian inference, was developed that adjusts the risk for individual-specific factors, and for spatial or individual over-dispersion, respectively. Additionally, the model takes into account conditional spatial autocorrelation. We found a significant positive association to the H. pylori infection risk for: “more than three children live in the household” (OR = 2.4, p = 0.001), “more persons live per sq.m than average” (OR = 1.4, p = 0.03), “home situated at main road” (OR = 1.4, p = 0.04) and “using well water” (OR = 2.3, p = 0.05). A protective effect was identified for “travelled to low prevalence region” (OR = 0.4, p < 0.0001) and “born in Germany” (OR = 0.2, p < 0.0001). Three administrative areas with significantly increased spatial risk were identified: one in the rural district and two in the city of Leipzig. The model explained 24.9% of the total deviance. Contrary to expectations, the largest part of deviance of the data was not explained by the identified significant risk factors, but by individual-specific heterogeneities. We conclude that further - so far not discussed - factors influence the risk and the spatial variation of the H.pylori infection. Furthermore, from the results we speculate about a possible impact of long-time air pollution and surface water.     

Anforderungen an Stahl‐ und Verbundknoten bei Stützenausfall in einem Rahmentragwerk

Eine lokale Schädigung innerhalb der Tragstruktur (z. B. Stützenausfall durch Anprall oder Explosion) kann zu einem Versagen der Gesamtstruktur und damit zum Einsturz des Gebäudes führen. Um solch ein globales Versagen durch lokale Schädigung zu vermeiden, muss innerhalb der Tragstruktur eine Umlagerung der Schnittgrößen ermöglicht werden, d. h., es müssen sich alternative Lastpfade ausbilden können. Solch eine Umlagerung, z. B. von einem reinen Biegezustand in einen gemischten Biege‐/Membranspannungszustand, bedingt unter Umständen sehr große Verformungen, die zu großen Deformationen der Anschlüsse führen. Im Rahmen eines europäischen RFCS‐Forschungsprojektes wurde versucht, mit Hilfe sehr duktiler Anschlussausbildungen die Robustheit von Stahl‐ und Verbundrahmentragwerken zu verbessern. Hauptaugenmerk bei der Konzeption der Anschlüsse war dabei, den Material‐ und Fertigungsaufwand der Anschlüsse so gering wie möglich zu halten und die Umlagerungsmöglichkeiten für außergewöhnliche Bemessungssituationen vornehmlich über das Vorhalten hoher Verformungskapazitäten der Anschlüsse zu aktivieren. Aus diesem Grund wurden hier nachgiebige teiltragfähige Anschlüsse gewählt. Als außergewöhnliche Bemessungssituation wurde in diesem Projekt schwerpunktmäßig der Stützenausfall in einem Rahmentragwerk betrachtet. (RFCS Research Fund for Coal and Steel) Requirements on steel‐ and composite joints for the load case column removal. Local failure in a structure (e. g. sudden column loss due to impact or explosion) may lead to progressive collapse propagation of the global structural system resulting in a total collapse. To avoid progressive collapse initiated by local damage a redistribution of force from the damaged part of the structure has to be enabled by alternate load paths. Activation of alternate load paths by change of the bearing mechanism from pure bending state to more or less pure membrane state is a measure that is only possible by allowing large deformations resulting in high deformation requirements for the joints. In the course of an European RFCS research project ductile joint solutions have been developed to improve the robustness as characteristic of the structure. Main focus of the joint design was to obtain the required deformation capacity for accidental design situations mainly from ductile joint and cause at the same time only few additional material and fabrication costs for the joints. As a result semi‐rigid and partial‐strength joint solutions have been chosen. Objectives within the project were to determine requirements of the joints concerning deformation capacity as well as M‐N‐resistance to enable the activation of catenary action for the load case notional column removal.     

Escape trajectories are deflected when fish larvae intercept their own C-start wake

Fish larvae may intercept their own wake during sharp turns, which might affect their escape performance. We analysed C-starts of larval zebrafish (Danio rerio, Hamilton, 1822) using a computational fluid dynamics approach that simulates free swimming (swimming trajectory is determined by fluid forces) by coupling hydrodynamics and body dynamics. The simulations show that fish may intercept their own wake when they turn by 100–180°. During stage 1 of a C-start, the fish generates a strong jet at the tail that is shed into the wake. During stage 2, the fish intercepts this wake. Counterfactual simulations showed that wake interception increased the lateral force on the fish and reduced the fish''s turning angle by more than 5°. Wake interception caused no significant acceleration tangential to the trajectory of the fish and did not affect total power output. While experimental and simulation evidence suggests that fish larvae can either undershoot or intercept but not overshoot their wake, our simulations show that larger fish might be able to avoid intercepting their wake by either under- or overshooting. As intercepting its own wake modifies the fish''s escape trajectory, fish should account for this effect when planning their escape route.     

Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration

Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-α-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-α-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.     

New crosslinkers for electrospun chitosan fibre mats. I. Chemical analysis

Chitosan (CS), the deacetylated form of chitin, the second most abundant, natural polysaccharide, is attractive for applications in the biomedical field because of its biocompatibility and resorption rates, which are higher than chitin. Crosslinking improves chemical and mechanical stability of CS. Here, we report the successful utilization of a new set of crosslinkers for electrospun CS. Genipin, hexamethylene-1,6-diaminocarboxysulphonate (HDACS) and epichlorohydrin (ECH) have not been previously explored for crosslinking of electrospun CS. In this first part of a two-part publication, we report the morphology, determined by field emission scanning electron microscopy (FESEM), and chemical interactions, determined by Fourier transform infrared microscopy, respectively. FESEM revealed that CS could successfully be electrospun from trifluoroacetic acid with genipin, HDACS and ECH added to the solution. Diameters were 267 ± 199 nm, 644 ± 359 nm and 896 ± 435 nm for CS–genipin, CS–HDACS and CS–ECH, respectively. Short- (15 min) and long-term (72 h) dissolution tests (T₆₀₀) were performed in acidic, neutral and basic pHs (3, 7 and 12). Post-spinning activation by heat and base to enhance crosslinking of CS–HDACS and CS–ECH decreased the fibre diameters and improved the stability. In the second part of this publication, we report the mechanical properties of the fibres.     

Ein Japaner in Marburg

The heart of this article is the transmission of selected chapters from the Japanese bacteriologist Taichi Kitashima’s (1870–1956) autobiographical memoirs (in Japanese, Jiden) published in 1955, in which Kitashima reports on his stay in Marburg in a very personal and subjective way. Like other Japanese physicians of his generation, Kitashima spent several years in Germany in order to work with the serum researcher Emil von Behring and continued his education there. The contact came through Kitashima’s teacher Shibasaburô Kitasato, who had worked with Behring in Berlin on questions of immunology. The memoir gives insight into Behring’s laboratory work and his relation to his “subordinates”. The editors investigate to what extent Kitashima’s assessment, made from a distance of fifty years, of his stay in Germany as “wasted time” was accurate, given the advantages that arose from having been part of a vibrant European scientific community, including encounters in the Pasteur Institute in Paris, and why he cultivated his contacts with Germany and the Behring family during National Socialism.     

Dumbbells,Trikes and Quads: Organic–Inorganic Hybrid Nanoarchitectures Based on “Clicked” Gold Nanoparticles

The controlled assembly of gold nanoparticles in terms of the spatial arrangement and number of particles is essential for many future applications like electronic devices, sensors and labeling. Here an approach is presented to build up oligomers of mono functionalized gold nanoparticles by the use of 1,3‐bipolar azide alkyne cycloaddition click chemistry. The gold nanoparticles of 1.3 nm diameter are stabilized by one dendritic thioether ligand comprising an alkyne function. Together with di‐, tri‐ and tetra‐azide linker molecules the gold nanoparticle can be covalently coupled by a wet chemical protocol. The reaction is tracked with IR and UV–vis spectroscopy and the yielded organic‐inorganic hybrid structures are analyzed by transmission electron microscopy. To evaluate the success of this click chemistry reaction statistical analysis of the formed oligomers is performed. The geometric and spatial arrangements of the found oligomers match perfectly the calculated values for the used linker molecules. Dimers, trimers and tetramers could be identified after the reaction with the corresponding linker molecule. The results of this model reaction suggest that the used click chemistry protocol is working well with mono functionalized gold nanoparticles.