The significance of air velocity and turbulence intensity for responses to horizontal drafts in a constant air temperature of 23°C

Aim: The aim was to prove the significance of air velocity and turbulence intensity on the responses to drafts and if air velocity is adequately weighted in the draft rating model (DR-model) proposed in ISO 7730 (1994). Methods: Seventeen healthy persons (9 women, 8 men, 19–51 yr) took part in 12 randomly arranged 1-h sessions where horizontal drafts were directed towards the dorsolateral body sites of the sedentary persons. Mean air velocity was varied in 4 (  m/s) and turbulence intensity in 3 steps (Tu: <30,≈50,>70%) but were kept constant during the single sessions, whereas air velocities were increased every 15 min in the basic experiments performed for the DR-model. Air temperature was 23°C, humidity varied between 40% and 60%. Subjective perception and annoyance due to drafts were registered every 5 min using a list of prescribed body parts and skin temperature was measured continuously throughout the sessions at the forearm and at the neck. Results: Draft-induced general annoyance (if draft-induced annoyance was stated for at least one body site) and draft-induced local annoyance as stated for the neck and for the forearm increased with air velocity and/or with turbulence intensity. The decrease in skin temperature, however, was only related to air velocity but not to turbulence intensity. Air velocities are obviously not accurately weighted in the draft-rating model (ISO 7730, 1994). As compared to the effects observed here, the effects predicted with the DR-model were smaller in case of mean air velocities of 0.3 m/s and less but greater for 0.4 m/s. Concerning rather sedentary persons it seems that drafts are tolerable as long as mean air velocities do not exceed 0.2 m/s and as long as turbulence intensity remains below 30% in air temperature of 23°C.

Relevance to industry

Drafts are the most annoying climatic factor at many workplaces and assumed to reduce satisfaction with work, to impair performance and perhaps even health (Griefahn et al., Ind. Health 38 (2000b) 30). The limitation of drafts is therefore an important contribution to industrial safety. Using the draft-rating model proposed in ISO 7730 (1994) for the evaluation and for the prediction of draft-induced annoyance, it must be considered that the model underestimates the effects of drafts in case of air velocities of 0.3 m/s which prevail at more than 85% of workplaces in offices and in the industry (Griefahn, 1999; Zhou, Ph.D. Thesis, International Center for Indoor Environment and Energy, Department of Energy Engineering, Technical University of Denmark, Lyngby, 1999).     

Basic model for membrane electrode assembly design for direct methanol fuel cells

This research proposes a model that predicts the effect of the anode diffusion layer and membrane properties on the electrochemical performance and methanol crossover of a direct methanol fuel cell (DMFC) membrane electrode assembly (MEA). It is an easily extensible, lumped DMFC model. Parameters used in this design model are experimentally obtainable, and some of the parameters are indicative of material characteristics. The quantification of these material parameters builds up a material database. Model parameters for various membranes and diffusion layers are determined by using various techniques such as polarization, mass balance, electrochemical impedance spectroscopy (EIS), and interpretation of the response of the cell to step changes in current. Since the investigation techniques cover different response times of the DMFC, processes in the cell such as transport, reaction and charge processes can be investigated separately. Properties of single layers of the MEA are systematically varied, and subsequent analysis enables identification of the influence of the layer's properties on the electrochemical performance and methanol crossover. Finally, a case study indicates that the use of a membrane with lower methanol diffusivity and a thicker anode micro-porous layer (MPL) yields MEAs with lower methanol crossover but similar power density.     

Thesen und Trends &#x0096; Mit funktionalen Oberflächen in die Zukunft

Propositions and Trends &#x0096; With Functional Surfaces into the Future Functional surfaces are the key to innovative products. Already today the properties, lifetime, and costs for most industrial and consumer products are determined by functionalised surfaces. Three Fraunhofer Institutes supported by the BMBF investigated the actual state of the art of production technology regarding functional surfaces, their future perspectives and the research and development demand. The results are published in the study “Production technology for the generation of functional surfaces” available at info@ist.‐ fraunhofer.de and the essentials are summarised in this article.     

Dielectric and lattice-dynamical properties of III-nitrides

First-principles calculations are performed to investigate dynamical and dielectric properties of group-III-nitrides. We focus on vibrational frequencies, dynamical charges, and the phonon density of states of cubic AlN, GaN, and InN. Chemical trends are derived and discussed. The first ab initio calculations of phonon branches and density of states are presented for an ordered In_xGa_1−xN structure.     

The Conversion of UDP-Glc to UDP-Man: In Silico and Biochemical Exploration To Improve the Catalytic Efficiency of CDP-Tyvelose C2-Epimerases

A promiscuous CDP-tyvelose 2-epimerase (TyvE) from Thermodesulfatator atlanticus (TaTyvE) belonging to the nucleotide sugar active short-chain dehydrogenase/reductase superfamily (NS-SDRs) was recently discovered. TaTyvE performs the slow conversion of NDP-glucose (NDP-Glc) to NDP-mannose (NDP-Man). Here, we present the sequence fingerprints that are indicative of the conversion of UDP-Glc to UDP-Man in TyvE-like enzymes based on the heptagonal box motifs. Our data-mining approach led to the identification of 11 additional TyvE-like enzymes for the conversion of UDP-Glc to UDP-Man. We characterized the top two wild-type candidates, which show a 15- and 20-fold improved catalytic efficiency, respectively, on UDP-Glc compared to TaTyvE. In addition, we present a quadruple variant of one of the identified enzymes with a 70-fold improved catalytic efficiency on UDP-Glc compared to TaTyvE. These findings could help the design of new nucleotide production pathways starting from a cheap sugar substrate like glucose or sucrose.     

Policies to support renewable energies in the heat market

Whereas the contribution from renewable energies in the electrical power market is increasing rapidly, similar progress in the heat market is yet to be made. A prerequisite for progress is the development of innovative support instruments that transcend the usual support through public subsidies or tax reductions. We present an overview of the various classes of possible instruments. Some particularly interesting instruments will be selected and evaluated, comparing them qualitatively and quantitatively for the case of Germany. The most favourable model is found to be a new, allocation-financed¹ model known as the Bonus Model. This model will be described in more detail.     

The Oncolytic Adenovirus XVir-N-31, in Combination with the Blockade of the PD-1/PD-L1 Axis,Conveys Abscopal Effects in a Humanized Glioblastoma Mouse Model

Glioblastoma (GBM) is an obligatory lethal brain tumor with a median survival, even with the best standard of care therapy, of less than 20 months. In light of this fact, the evaluation of new GBM treatment approaches such as oncolytic virotherapy (OVT) is urgently needed. Based on our preliminary preclinical data, the YB-1 dependent oncolytic adenovirus (OAV) XVir-N-31 represents a promising therapeutic agent to treat, in particular, therapy resistant GBM. Preclinical studies have shown that XVir-N-31 prolonged the survival of GBM bearing mice. Now using an immunohumanized mouse model, we examined the immunostimulatory effects of XVir-N-31 in comparison to the wildtype adenovirus (Ad-WT). Additionally, we combined OVT with the inhibition of immune checkpoint proteins by using XVir-N-31 in combination with nivolumab, or by using a derivate of XVir-N-31 that expresses a PD-L1 neutralizing antibody. Although in vitro cell killing was higher for Ad-WT, XVir-N-31 induced a much stronger immunogenic cell death that was further elevated by blocking PD-1 or PD-L1. In vivo, an intratumoral injection of XVir-N-31 increased tumor infiltrating lymphocytes (TILs) and NK cells significantly more than Ad-WT not only in the virus-injected tumors, but also in the untreated tumors growing in the contralateral hemisphere. This suggests that for an effective treatment of GBM, immune activating properties by OAVs seem to be of greater importance than their oncolytic capacity. Furthermore, the addition of immune checkpoint inhibition (ICI) to OVT further induced lymphocyte infiltration. Consequently, a significant reduction in contralateral non-virus-injected tumors was only visible if OVT was combined with ICI. This strongly indicates that for an effective eradication of GBM cells that cannot be directly targeted by an intratumoral OV injection, additional ICI therapy is required.