Correlation between the antiarrhythmic activity of acyl derivatives of phenothiazine and their affinity for phospholipid membranes

The interaction of thirteen antiarrhythmic active phenothiazine 10-acylaminopropionil derivatives with artificial phospholipid membranes was studied. Blinding constant (K) of this interaction was determined by means of a fluorescent probe. There was found a valid correlation between K and antiarrhythmic activity (A) for 10 substances; the greater the K--the greater the A. Three substances characterized by the greatest K had, however, a low A. It can be assumed that the interaction of antiarrhythmic drugs with phospholipids of target membranes in vivo is an important element of the molecular mechanism of action. At the same time a very high affinity to lipids can possibly cause a delocalization of the drug in the organism and a decrease of its antiarrhythmic activity.     

Medical provisions for the immediate post-flight period following long space flights

At the final stage of long-term space flights first aid should be rendered in a specific way in cases of critical situations. Resuscitation and anesthesiology measures should be applied, if necessary, after study of flight-induced changes in the vital organs and systems. The paper describes the most important factors that should determine the tactics of resuscitation-anesthesiology support of the immediate postflight stage, if theoretically feasible acute life-endangering states develop. It also presents substantiated correction of routine clinical protocols of resuscitation aid.     

Specific inhibition of macrophage adherence in animals with post-traumatic autoallergic aspermatogenesis

The macrophage adherence inhibition was studied in the peritoneal macrophages of guinea pigs with induced posttraumatic aspermatogenesis at various periods after the testis injury. Reliable peritoneal macrophages adherence inhibition was observed in the presence of the testis-specific antigen. The adherence inhibition reflected the autoimmune character of the testis affection.