Function of saposin C in the reconstitution of glucosylceramidase by phosphatidylserine liposomes

The function of saposin C (Sap C), a glucosylceramidase activator protein, in the enzyme stimulation by phosphatidylserine (PS) liposomes has been investigated. Using gel filtration experiments evidence was obtained for Sap C binding to PS large unilamellar vesicles (LUV) but not to glucosylceramidase. PS LUV, which by themselves are unable to tightly bind and stimulate the enzyme, acquire the capacity to also bind the enzyme after interaction with Sap C, making it express its full activity. Our results indicate that the primary step in the Sap C mode of action resides in its association with PS membranes; in turn, this association promotes the interaction between the membranes and glucosylceramidase.     

A distributed architecture for online power systems security analysis

Phenomena that can compromise power systems operation need to be carefully analyzed in order to evaluate their impact on the security and reliability levels of the electrical networks. The real-time assessment of the system's security and reliability levels, especially under unforeseen contingencies, is known as online power system security analysis. For complex networks this process requires large computational efforts whereas computation times should be less than a few minutes for the information to be useful. To address this problem a distributed architecture based on the Web is proposed. The architecture integrates a network of remotely controlled units distributed in the most critical sections of the electrical network for fields data acquisition and safety check violations, a distributed solution engine for the online analysis of the system security, and a Web-based interface for graphical synoptic and reporting development. The results obtained from an intensive experimentation demonstrate the validity of the architecture and stimulate the enhancement of the solution engine through the use of a computational grid able to dynamically acquire the needed resources.     

Graph decompositions and secret sharing schemes

In this paper we continue a study of secret sharing schemes for-access structures based on graphs. Given a graph G, we require that a subset of participants can compute a secret key if they contain an edge of G; otherwise, they can obtain no information regarding the key. We study the information rate of such schemes, which measures how much information in being distributed as shares compared with the size of the secret key, and the average information rate, which is the ratio between the secret size and the arithmetic mean of the size of the shares. We give both upper and lower bounds on the optimal information rate and average information rate that can be obtained. Upper bounds arise by applying entropy arguments due to Capocelli et al. [15]. Lower bounds come from constructions that are based on graph decompositions. Application of these constructions requires solving a particular linear programming problem. We prove some general results concerning the information rate and average information rate for paths, cycles, and trees. Also, we study the 30 (connected) graphs on at most five vertices, obtaining exact values for the optimal information rate in 26 of the 30 cases, and for the optimal average information rate in 28 of the 30 cases.The research of C. Blundo, A. De Santis, and U. Vaccaro was partially supported by the Italian Ministry of University and Research (M.U.R.S.T.) and by the National Council for Research (C.N.R.) under Grant 91.02326.CT12. The research of D. R. Stinson was supported by NSF Grant CCR-9121051.     

Integration of magneto-optical garnet films by metal-organicchemical vapor deposition

This paper presents a novel technique for integrating yttrium iron garnets, namely Ce:YIG, onto semiconductor platforms using metal-organic chemical vapor deposition (MOCVD). Large amounts of cerium (Ce) could be incorporated into the garnet structure because of the nonequilibrium nature of the technique. The method can alloy up to 54% Ce, thereby increasing the refractive index and enhancing the Faraday rotation of the YIG films. Faraday rotations as high as 0.4°/μm at 1.3 μm were achieved in MOCVD-grown garnets, exceeding the rotations of bismuth-doped YIG films (0.15°/μm at 1.3 μm) grown by liquid-phase epitaxy. The easy axis of magnetization is within the plane of the films. When the garnet films were sputtered onto (100) magnesia (MgO) buffer layers, their hysteresis loops indicated that they were isotropic     

The ITER EC H&CD upper launcher: Structural design

Four ITER EC H&CD (Electron Cyclotron Heating and Current Drive) Upper Launchers will be installed in the ITER Tokamak to counteract plasma instabilities by injection of up to 20 MW of millimeter-wave power at 170 GHz. Each Launcher features a structural system which is equipped with eight beam lines in a Front-Steering arrangement. The Launcher development has reached the status of a preliminary design, since the corresponding review meeting was held in November 2009 at the ITER site in Cadarache. All design work is performed by several EU associations being contracted by Fusion for Energy (F4E). The structural design of the Upper Launcher consists of three sub-components: First of all the Blanket Shield Module (BSM), which fills the gap between the regular blankets. The BSM dissipates about 80% of the nuclear heating and envelopes the front mirrors of the mm-wave system. Further the Launcher Mainframe, which provides a rigid structure for precise and secure integration of the mm-wave system to guarantee reliable operation under all potential scenarios. Finally the internals, such as dedicated support structures for the mm-wave system, shielding elements and components for gas and coolant supply. The most challenging design aspects are proper dissipation of nuclear heating in zones of high heat flux, the mechanical integrity during plasma disruptions, the integration of sufficient shielding material and the precise alignment of the mm-wave system under tight space conditions. Furthermore the definition of efficient manufacturing routes with respect to tolerance compliance requires substantial investigation and, though the Launcher is designed for ITER lifetime, potential repair by adequate remote handling procedures must be considered. This paper presents the recent status of the preliminary structural design and outlines future design approaches with the main focus on manufacturing methods, remote handling capability of the sub-components and optimum integration of the internals to bring the EC Launcher towards the final design.     

Organic Small Molecules for Photonics and Electronics from the [2.2]Paracyclophane Scaffold

In the search for molecules for organic photonics and electronics, several strategies have been used to modulate physical and chemical properties of [2.2]paracyclophane derivatives by sequential functionalization of their three-dimensional cores. This review summarizes the major design and synthetic strategies for tuning paracyclophane-containing small molecules by introducing various moieties featuring (hetero)aromatic rings directly connected to each other, as well as alternating (hetero)aryl and ethylene or ethynylene units. Several examples are presented that elucidate the structural, optical, and electronic consequences of incorporating these fragments in the aromatic decks, particularly relating to applications in organic optoelectronics.     

Manufacturing studies of double wall components for the ITER EC H&CD upper launcher

To counteract plasma instabilities, Electron Cyclotron Launchers will be installed in four of the ITER Upper Ports. The structural system of an EC Upper Launcher accommodates the MM-wave-components and has to meet strong demands on alignment, removal of nuclear heat loads, mechanical strength and nuclear shielding. The EC Upper Launcher has successfully undergone the Preliminary Design Review in 2009 and is now in the final design phase. Nuclear heat loads from 0.1 W/cm³ up to 0.8 W/cm³ will affect the front area of the launcher main frame. To guarantee save and homogenous removal of those heat loads, the front part of the launcher main frame is designed as a double wall steel-casing with cooling channels inside the shell structure. To finalize the design of this double wall component, the main emphasis is now to define the cooling channels geometry and to identify the optimum manufacturing route to assure adequate flow of coolant and sufficient mechanical strength in compliance with required dimension tolerances and quality of the welds. Several manufacturing options have been investigated and were evaluated by computational analysis and fabrication of pre-prototypes. To come to a final design, the most promising route will be chosen to manufacture a full-size mock-up of the double wall main frame. It will be tested at the KIT Launcher Handling Test facility to check the compliance with the design goals related to geometrical accuracy and thermo-hydraulic characteristics. This paper describes the design and the manufacturing routes of the prototypic double wall main frame.     

Performance analysis of the state-space realization (TAM) andESPRIT algorithms for DOA estimation

The performance of signal-subspace-based algorithms for directions-of-arrival estimation involving multiple signal arrivals in array signal processing is analyzed. An analytical expression of the variance of the DOA estimation error is developed for three signal subspace based algorithms, state-space realization (SSR) (TAM), ESPRIT, and matrix pencil. Simulation results that verify the analysis are reported