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Elena Heister Vera Neves Carmen Tîlmaciu Vanesa Sanz Beltrán Helen M. Coley Johnjoe McFadden 《Carbon》2009,47(9):2152-2160
Single-walled carbon nanotubes (SWCNTs) have been identified as a transporter for anti-cancer drugs, as they are capable of penetrating mammalian cell membranes and allow for a high drug loading due to their nanoscale dimensions and high aspect ratio. In addition, they can assist the targeting of therapeutic agents to the desired site of action by conjugation to antibodies or ligands of cancer cell surface receptors, which increases the effectiveness of the treatment and reduces side effects. In this work, we present a method for the triple functionalisation of oxidised SWCNTs with the anti-cancer drug doxorubicin, a monoclonal antibody, and a fluorescent marker at non-competing binding sites. The proposed methodology allows for the targeted delivery of the anti-cancer drug to cancer cells and the visualisation of the cellular uptake of SWCNTs by confocal microscopy. We show that the complex is efficiently taken up by cancer cells with subsequent intracellular release of doxorubicin, which then translocates to the nucleus while the nanotubes remain in the cytoplasm. 相似文献
93.
It is shown in more detail how the well-documented history of nuclear fission in 1938/9 has been distorted by a legend.
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B. L. Ma Z. Zheng D. Pageau C. Vera J. Fregeau-Reid A. Xue W. Yan 《Nutrient Cycling in Agroecosystems》2017,108(3):245-265
Oat has been gaining renewed interest due to its role in human healthy diet. A field study was conducted across three diverse locations in Canada to determine N and P uptake, agronomic traits and yield performance of 10–12 cultivars under four fertilizer N rates. Our data showed that ‘SA060123’ and ‘OA1331-5’ were the highest-yielding cultivars, and ‘Dieter’ and ‘Morrison’ the lowest, across sites-years. Yield components were altered to adapt to soil-environmental conditions, specifically, panicles m?2 mostly accounted for yield variation at Melfort, seeds panicle?1 and 1000-seed weight at Normandin, and lodging index was an additional yield-determining factor at Ottawa. It was noted that severe crop lodging that occurred mainly at Ottawa, was logically associated with greater accumulation of straw N and plant biomass under high N supply conditions, and that crop lodging displayed a strong correlation with straw P content. Relationship of lodging index and straw P was best-fit into a split-line model with a change-point of 13.6 kg P ha?1, below which lodging rarely occurred. We speculate that high straw P content, induced by external N supply, may have exhibited similar behavior as N in weakening the strength of stem base and anchorage system, leading to crop lodging. This study also demonstrated an interactive genotype-by-environment effect on all traits except for the seed number panicle?1. Multidimensional preference analysis revealed the best performance of ‘SA060123’ for outstanding yield and 'Minstrel' for harvest index, respectively. 相似文献
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ABSTRACT The extraction of palladium (II) from chloride solutions (over a wide region of aqueous acidity) by di(2-ethylhexyl)dithiophosphates of tetraoctylammonium, tri-n-octylammonium and di-n-octylammonium in toluene at the constant chloride concentration has been studied. A synergistic effect was shown to be observed in these systems and it is explained by the formation of unusual complexes with mixed ligands. It has been established the palladium complexes, such as (R3NH)[PdCl2A], (R3NH)[PdCl2A] and (R2NH2)[PdCl2A], involving both alkylammonium cation and dialkyldithiophosphate anion are extracted under conditions of the loaded organic phase using distribution methods depending on a composition of aqueous and organic phase. At the excess of R3NHA or R2NH·HA, PdA2 is extracted into the organic phase. Table 8 reports the results obtained and indicates the domains of existence of the various species of palladium (II) extracted into the organic phase in the binary ex-tractant systems in comparison with the initial systems 相似文献
97.
Multilayered, counterflow, parallel-plate heat exchangers are analyzed numerically and theoretically. The analysis, carried out for constant property fluids, considers a hydrodynamically developed laminar flow and neglects longitudinal conduction both in the fluid and in the plates. The solution for the temperature field involves eigenfunction expansions that can be solved in terms of Whittaker functions using standard symbolic algebra packages, leading to analytical expressions that provide the eigenvalues numerically. It is seen that the approximate solution obtained by retaining the first two modes in the eigenfunction expansion provides an accurate representation for the temperature away from the entrance regions, specially for long heat exchangers, thereby enabling simplified expressions for the wall and bulk temperatures, local heat-transfer rate, overall heat-transfer coefficient, and outlet bulk temperatures. The agreement between the numerical and theoretical results suggests the possibility of using the analytical solutions presented herein as benchmark problems for computational heat-transfer codes. 相似文献
98.
Corfield Vera K.; Eriksen Maria K.; Webb Margaret; Buzzell Nancy L. 《Canadian Metallurgical Quarterly》1986,27(4):370
At a conference for female therapists in Canada, participants answered a questionnaire on issues and skills of therapists. Results indicate that the Ss were interested in (1) understanding themselves, their careers, and women's roles in society, and (2) a feminist approach to therapy. The responses suggest that the Ss' training as therapists was inadequate to the extent that it failed to address their own reality and that of women clients. (0 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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