Mode determination in noisy bimodal images by histogram comparison

This letter introduces the “mode determination” problem relative to a biomodal image corrupted by noise, i.e., the problem of estimating the mean intensity level of each of the two homogeneous regions constituting a bimodal image. The mode determination problem can be seen as a generalization of the threshold determination problem. This generalization is introduced to cope with the low performances of thresholding techniques when dealing with highly noisy images. A mode determination method is proposed, based on the comparison of the histogram of different (averaging) convolutions of the given image. Experimental results are presented showing the performance of the proposed method.     

Magic Angle Spinning-Cross Polarization 13C NMR of crosslinked unsaturated polyester resins

Summary Magic Angle Spinning-Cross Polarization (MAS-CP) ¹³C NMR spectra of four different unsatured resins reticulated with styrene have been measured.Styrene crosslinks may be constituted essentially by dyads or may consist in (styrene) microdomains (n2), depending mainly upon the molar ratio of maleic acid residues in the original unsaturated polyester to styrene.Also in the case of solid unsaturated resins the MAS-CP ¹³CNMR technique promises to allow structural insights only very difficultly obtainable by more classical indirect means.     

A Contribution to Tests Standardization for Inverter-Fed Asynchronous Machines

Losses of inverter-fed asynchronous motors and their experimental evaluation are considered. The formal expressions of iron and copper losses are first recalled, and it is shown as they are influenced by the harmonic content of inverter output voltages. Theoretical and experimental values of these losses are then given together with the presentation of the experimental tests used for their determination. A suitable set of tests is then suggested for the determination of the conventional efficiency of inverter-fed asynchronous motors. The content cannot be considered exhaustive on the matter. It represents only a first contributive approach to the standardization of inverter-fed asynchronous motor tests.     

Peak Response of a Nonlinear Beam

A model for estimating the peak dynamic response distribution of a nonlinear beam, based on a special class of non-Gaussian stochastic processes, is proposed in this paper. It is shown that the stochastic response of a cantilever beam with geometrically nonlinear behavior can be accurately calibrated with translation processes. Different models to describe the significant bimodal features in the marginal probability density functions of the response time histories are proposed. Finally, two of these models are used to estimate the response peak value distributions and the results are compared. This comparison demonstrates the effects of inaccurate models for the parent response processes on the peaks estimation.     

Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics,Kinase Pathways,and Cell Metabolism in Cancer Therapeutics

Copper is an essential transition metal frequently increased in cancer known to strongly influence essential cellular processes. Targeted therapy protocols utilizing both novel and repurposed drug agents initially demonstrate strong efficacy, before failing in advanced cancers as drug resistance develops and relapse occurs. Overcoming this limitation involves the development of strategies and protocols aimed at a wider targeting of the underlying molecular changes. Receptor Tyrosine Kinase signaling pathways, epigenetic mechanisms and cell metabolism are among the most common therapeutic targets, with molecular investigations increasingly demonstrating the strong influence each mechanism exerts on the others. Interestingly, all these mechanisms can be influenced by intracellular copper. We propose that copper chelating agents, already in clinical trial for multiple cancers, may simultaneously target these mechanisms across a wide variety of cancers, serving as an excellent candidate for targeted combination therapy. This review summarizes the known links between these mechanisms, copper, and copper chelation therapy.     

Chemoselective Additions of Chloromethyllithium Carbenoid to Cyclic Enones: A Direct Access to Chloromethyl Allylic Alcohols

Chloromethyllithium carbenoid has been chemoselectively added to cyclic enones (5‐, 6‐ and 7‐membered systems, including two natural products) to provide chloromethyl allylic alcohols. Under the optimized reaction conditions neither concomitant (n+1) homologation nor conjugate addition or Simmons–Smith‐like cyclopropanation takes place. The presence of LiBr is estimated to play a dual role, namely as a carbenoid stabilizer and mild Lewis acid activator of the CO group. Notably, the mesomeric effect caused by β‐heteroatom‐containing substituents promotes the attack of the reagent at the most activated position.

     

Combined effect of active coating and modified atmosphere packaging on prolonging the shelf life of low-moisture Mozzarella cheese

In this work, the effect of active coating on the shelf life of low-moisture Mozzarella cheese packaged in air and modified atmosphere (MAP) was studied. The active coating was based on sodium alginate (2%, wt/vol) and potassium sorbate (1%, wt/vol). The MAP was made up of 75% CO₂ and 25% N₂ (MAP1), 25% CO₂ and 75% N₂ (MAP2), or 50% CO₂ and 50% N₂ (MAP3). The product quality decay was assessed by monitoring microbiological and sensory changes during storage at 4, 8, and 14°C. Results showed that the combination of active coating and MAP was able to improve the preservation of low-moisture Mozzarella cheese. Specifically, the shelf life increased up to 160 d for samples stored at 4°C, and 40 and 11 d for those at 8 and 14°C, respectively. A faster quality decay for untreated samples packaged in air was observed. In particular, the Pseudomonas spp. growth and the appearance of molds were responsible for product unacceptability. The combination of active coating and MAP represents a strategic solution to prolong the shelf life of low-moisture Mozzarella cheese and to ensure the safety of the product under thermal abuse conditions.     

Isolation and characterization of tyramine-producing Enterococcus faecium strains from red wine

Enterococcus faecium strains were isolated from red wines undergoing malolactic fermentation and identified by comparison of their 16S rDNA gene sequences with those included in the GenEMBL Databases. The tyrosine decarboxylase gene was identified in all the strains analysed by PCR using gene-specific primers and the ability to produce tyramine in a synthetic media was analysed by RP-HPLC. Survival of an E. faecium strain was also evaluated in microvinification assays using two different musts with different ethanol concentrations (10% and 12% (v/v)). Tyramine production was monitored during the vinification trials. Our results suggest that E. faecium strains isolated from wine are able to produce tyramine and tolerate wine conditions following a pre-acidic stress.     

The Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something?

The cure rate of germ cell tumours (GCTs) has significantly increased from the late 1970s since the introduction of cisplatin-based therapy, which to date remains the milestone for GCTs treatment. The exquisite cisplatin sensitivity has been mainly explained by the over-expression in GCTs of wild-type TP53 protein and the lack of TP53 somatic mutations; however, several other mechanisms seem to be involved, many of which remain still elusive. The findings about the role of TP53 in platinum-sensitivity and resistance, as well as the reported evidence of second cancers (SCs) in GCT patients treated only with surgery, suggesting a spectrum of cancer predisposing syndromes, highlight the need for a deepened understanding of the role of TP53 in GCTs. In the following report we explore the complex role of TP53 in GCTs cisplatin-sensitivity and resistance mechanisms, passing through several recent genomic studies, as well as its role in GCT patients with SCs, going through our experience of Center of reference for both GCTs and cancer predisposing syndromes.     

Complexity of Rational and Irrational Nash Equilibria

We introduce two new natural decision problems, denoted as ? RATIONAL NASH and ? IRRATIONAL NASH, pertinent to the rationality and irrationality, respectively, of Nash equilibria for (finite) strategic games. These problems ask, given a strategic game, whether or not it admits (i) a rational Nash equilibrium where all probabilities are rational numbers, and (ii) an irrational Nash equilibrium where at least one probability is irrational, respectively. We are interested here in the complexities of ? RATIONAL NASH and ? IRRATIONAL NASH. Towards this end, we study two other decision problems, denoted as NASH-EQUIVALENCE and NASH-REDUCTION, pertinent to some mutual properties of the sets of Nash equilibria of two given strategic games with the same number of players. The problem NASH-EQUIVALENCE asks whether or not the two sets of Nash equilibria coincide; we identify a restriction of its complementary problem that witnesses ? RATIONAL NASH. The problem NASH-REDUCTION asks whether or not there is a so called Nash reduction: a suitable map between corresponding strategy sets of players that yields a Nash equilibrium of the former game from a Nash equilibrium of the latter game; we identify a restriction of NASH-REDUCTION that witnesses ? IRRATIONAL NASH. As our main result, we provide two distinct reductions to simultaneously show that (i) NASH-EQUIVALENCE is co- $\mathcal{NP}$ -hard and ? RATIONAL NASH is $\mathcal{NP}$ -hard, and (ii) NASH-REDUCTION and ? IRRATIONAL NASH are both $\mathcal{NP}$ -hard, respectively. The reductions significantly extend techniques previously employed by Conitzer and Sandholm (Proceedings of the 18th Joint Conference on Artificial Intelligence, pp. 765–771, 2003; Games Econ. Behav. 63(2), 621–641, 2008).