Journal of Materials Science: Materials in Electronics - In the present work, pure BiFeO3 and pure Bi2Fe4O9 single phases were successfully synthesized by tailoring hydrothermal synthesis route.... 相似文献
Since the time of Huygens in the 17th century it has been believed that, if the weight of the structural members themselves
are negligible in comparison to the applied load, the optimum structure to carry a uniformly distributed load between pinned
supports will take the form of a parabolic arch rib (or, equivalently, a suspended cable). In this study, numerical layout
optimization techniques are used to demonstrate that when a standard material with equal tension and compressive strength
is involved, a simple parabolic arch rib is not the true optimum structure. Instead, a considerably more complex structural
form, comprising a central parabolic section and networks of truss bars in the haunch regions, is found to possess a lower
structural volume. 相似文献
A novel, label-free folding induced aptamer-based electrochemical biosensor for the detection of chloramphenicol (CAP) in the presence of its analogues has been developed. CAP is a broad-spectrum antibiotic that has lost its favor due to its serious adverse toxic effects on human health. Aptamers are artificial nucleic acid ligands (ssDNA or RNA) able to specifically recognize a target such as CAP. In this article, the aptamers are fixed onto a gold electrode surface by a self-assembly approach. In the presence of CAP, the unfolded ssDNA on the electrode surface changes to a hairpin structure, bringing the target molecules close to the surface and triggering electron transfer. Detection limits were determined to be 1.6 × 10(-9) mol L(-1). In addition, thiamphenicol (TAP) and florfenicol (FF), antibiotics with a structure similar to CAP, did not influence the performance of the aptasensor, suggesting a good selectivity of the CAP-aptasensor. Its simplicity and low detection limit (because of the home-selected aptamers) suggest that the electrochemical aptasensor is suitable for practical use in the detection of CAP in milk samples. 相似文献
A novel hybrid fiber reinforced polymer (FRP)–concrete structural system was applied to bridge superstructures. The hybrid FRP–concrete bridge superstructure systems are intended to have durable, structurally sound, and cost effective hybrid system that will take full advantage of the inherent and complementary properties of FRP materials and concrete. The proposed hybrid FRP–concrete system consists of trapezoidal FRP cell units surrounded by an FRP outer shell forming a bridge system. A thin layer of concrete was placed in the compression zone.
As a trial case, a prototype bridge superstructure was designed as a simply-supported single span one-lane bridge with a span length of 18.3 m. Performance of this superstructure was examined both experimentally and computationally. A test specimen, fabricated as a one-fourth scale model of the prototype bridge, was subjected to a series of loading tests: nondestructive tests (flexure, off-axis flexure, and negative flexure), and destructive tests (flexure and shear).
Results from both experimental and computational analysis confirmed that the proposed hybrid bridge superstructure system has an excellent performance from structural engineering point of view. Furthermore, it was shown that a detailed linear finite element analysis (FEA) could predict behavior of the test specimen under different service loading conditions. 相似文献
We use time-resolved interferometry, fluorescence assays and computational fluid dynamics (CFD) simulations to examine the viability of confluent adherent cell monolayers to selection via laser microbeam release of photoresist polymer micropallets. We demonstrate the importance of laser microbeam pulse energy and focal volume position relative to the glass–pallet interface in governing the threshold energies for pallet release as well as the pallet release dynamics. Measurements using time-resolved interferometry show that increases in laser pulse energy result in increasing pallet release velocities that can approach 10 m s−1 through aqueous media. CFD simulations reveal that the pallet motion results in cellular exposure to transient hydrodynamic shear stress amplitudes that can exceed 100 kPa on microsecond timescales, and which produces reduced cell viability. Moreover, CFD simulation results show that the maximum shear stress on the pallet surface varies spatially, with the largest shear stresses occurring on the pallet periphery. Cell viability of confluent cell monolayers on the pallet surface confirms that the use of larger pulse energies results in increased rates of necrosis for those cells situated away from the pallet centre, while cells situated at the pallet centre remain viable. Nevertheless, experiments that examine the viability of these cell monolayers following pallet release show that proper choices for laser microbeam pulse energy and focal volume position lead to the routine achievement of cell viability in excess of 90 per cent. These laser microbeam parameters result in maximum pallet release velocities below 6 m s−1 and cellular exposure of transient hydrodynamic shear stresses below 20 kPa. Collectively, these results provide a mechanistic understanding that relates pallet release dynamics and associated transient shear stresses with subsequent cellular viability. This provides a quantitative, mechanistic basis for determining optimal operating conditions for laser microbeam-based pallet release systems for the isolation and selection of adherent cells. 相似文献
Journal of Superconductivity and Novel Magnetism - A nanostructured nickel–iron alloy having the Ni40Fe60 composition was prepared through the mechanical alloying of the elemental powders in... 相似文献
Internet of Everything (IoE) indicates a fantastic vision of the future, where everything is connected to the internet, providing intelligent services and facilitating decision making. IoE is the collection of static and moving objects able to coordinate and communicate with each other. The moving objects may consist of ground segments and flying segments. The speed of flying segment e.g., Unmanned Ariel Vehicles (UAVs) may high as compared to ground segment objects. The topology changes occur very frequently due to high speed nature of objects in UAV-enabled IoE (Ue-IoE). The routing maintenance overhead may increase when scaling the Ue-IoE (number of objects increases). A single change in topology can force all the objects of the Ue-IoE to update their routing tables. Similarly, the frequent updating in routing table entries will result more energy dissipation and the lifetime of the Ue-IoE may decrease. The objects consume more energy on routing computations. To prevent the frequent updation of routing tables associated with each object, the computation of routes from source to destination may be limited to optimum number of objects in the Ue-IoE. In this article, we propose a routing scheme in which the responsibility of route computation (from neighbor objects to destination) is assigned to some IoE-objects in the Ue-IoE. The route computation objects (RCO) are selected on the basis of certain parameters like remaining energy and mobility. The RCO send the routing information of destination objects to their neighbors once they want to communicate with other objects. The proposed protocol is simulated and the results show that it outperform state-of-the-art protocols in terms of average energy consumption, messages overhead, throughput, delay etc. 相似文献
The most frequent mutated oncogene family in the history of human cancer is the RAS gene family, including NRAS, HRAS, and, most importantly, KRAS. A hallmark of pancreatic cancer, recalcitrant cancer with a very low survival rate, is the prevalence of oncogenic mutations in the KRAS gene. Due to this fact, studying the function of KRAS and the impact of its mutations on the tumor microenvironment (TME) is a priority for understanding pancreatic cancer progression and designing novel therapeutic strategies for the treatment of the dismal disease. Despite some recent enlightening studies, there is still a wide gap in our knowledge regarding the impact of KRAS mutations on different components of the pancreatic TME. In this review, we will present an updated summary of mutant KRAS role in the initiation, progression, and modulation of the TME of pancreatic ductal adenocarcinoma (PDAC). This review will highlight the intriguing link between diabetes mellitus and PDAC, as well as vitamin D as an adjuvant effective therapy via TME modulation of PDAC. We will also discuss different ongoing clinical trials that use KRAS oncogene signaling network as therapeutic targets. 相似文献
ABSTRACTThe present work describes a remarkable synthetic interest of semiconducting core-shell nanocomposites (CSNCs) contained aluminum oxide. Al2O3@terpoly(aniline, anthranilic acid, and o-phenylenediamine) (Al2O3/PANI-AA-o-PDA) CSNCs were fabricated by the fivefold molar ratio of the appropriate moieties with various quantities of γ-Al2O3 by oxidative polymerization. The formation of the Al2O3/PANI-AA-o-PDA CSNCs was confirmed by spectral characteristics. The feature of CSNCs is core-shell nano-rods structure with sizes 19–39 nm. The recorded σdc is 8.8 × 10?9-4.8 × 10?8 Ω?1 m?1 being in the range of semiconductor materials at room temperature and increases with increasing temperature. The newly fabricated materials were investigated as antimicrobial agents. The setup presents a facile, cheap, novel and beneficial methodology to develop novel CSNCs acquiring the required numerous functionality. 相似文献