Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy

Most anticancer drugs with broad toxicities are systematically administrated to cancer patients and their distribution in tumors is extremely low owing to hypoxia, which compromises the therapeutic efficacies of these cancer drugs. Consequently, a preponderant proportion of cancer drugs is distributed in off-target-healthy tissues, which often causes severe adverse effects. Precision cancer therapy without overdosing patients with drugs remains one of the most challenging issues in cancer therapy. Here, a novel concept of nanopoxia is presented, which is a tumor-hypoxia-based photodynamic nanoplatform for the release of therapeutic agents to achieve precision cancer therapy. Under tumor hypoxia, exposure of tumors to laser irradiation induces the fracture of polymer outer shell and produces anticancer reactive oxygen species, and switches 2D antimonene (Sb) nanomaterials to cytotoxic trivalent antimony to synergistically kill tumors. In preclinical cancer models, delivery of Sb nanomaterials to mice virtually ablates tumor growth without producing any detectable adverse effects. Mechanistically, the tumor hypoxia-triggered generation of trivalent antimony displays direct damaging effects on cancer cells and suppression of tumor angiogenesis. Together, the study provides a proof-of-concept of hypoxia-based precision cancer therapy by developing a novel nanoplatform that offers multifarious mechanisms of cancer eradication.     

基于DSP图形液晶显示器接口及程序设计

对基于DSP的图形液晶显示的研究做了一定的探讨,分析了基于DSP的图形液晶显示器的硬件电路以及程序设计。利用CCS开发环境,设计出一个基于DSP的图形液晶显示屏,能达到与程序运行相符合的显示结果。即通过更改、调试程序,最终实现静态显示、动态垂直向上向下滚屏显示、左右半屏从右至左逐字显示、全屏从左至右逐字显示汉字的功能,其他功能的实现有待进一步的研究。     

Influence of window layer thickness on double layer antireflection coating for triple junction solar cells

The optimization of a SiO₂/TiO₂,SiO₂/ZnS double layer antireflection coating（ARC）on Ga_0.5In_0.5P/In_0.02Ga_0.98As/Ge solar cells for terrestrial application is discussed.The Al_0.5In_0.5P window layer thickness is also taken into consideration.It is shown that the optimal parameters of double layer ARC vary with the thickness of the window layer.     

多散射介质中光子密度波扩散方程的求解

将光源作为一个复数点光源,根据实验研究模型的要求,求解了多散射介质中光子密度波扩散方程,找出了与入射面相对应面的光子通量和介质中吸收系数改变量之间的关系。所得结论能直接用于多散射介质中成像问题的实验研究之中,即通过对光子通量的检测,反演出吸收系数改变量的分布,从而达到多散射介质中的成像问题的解决。     

1064nm RCE探测器光电响应特性分析

对1064nm谐振腔增强型（RCE）光电探测器(PD)的光电响应特性进行了分析研究．利用MBE生长技术得到有源区分别为量子阱和量子点的1064nm RCE探测器的外延片,并对制作的探测器进行了各种光电特性测试．结果表明量子阱结构的RCE探测器量子效率峰值达到57%,谱线半宽6～7nm,峰值波长1059nm;而量子点结构的RCE探测器量子效率峰值达到30%,谱线半宽5nm,峰值波长1056nm．通过分析量子效率和吸收系数之间的关系,对两种结构器件的吸收进行了比较,发现虽然量子点探测器的吸收小,但通过合理设计共振腔等方法也可以达到较高的量子效率．两种结构的器件都有很好的Ｉ-Ｖ特性．     

Precise FPN compensation circuit for CMOS APS [imager]

Fixed pattern noise (FPN) is one of the major disadvantages of CMOS imagers in comparison with CCD imagers. A simple and precise FPN compensation circuit for a CMOS active pixel sensor (APS) imager with an in-line non-destructive readout function is presented     

第三届亚洲地区应用电磁学国际学术会议(ASAEM'2001)总结

介绍了 3月底在浙江大学召开的第三届亚洲地区应用电磁学国际学术会议的概况 ,从会议交流的论文与讨论中列述了当前该学科的进度 ,综述了我国在应用电磁学科的现状与展望 ,最后对会议的评价与成果作一小结。     

数字滤波器仿真软件评估的谱分析方法研究

本文讨论了仿真模型验证常用的技术方法,针对数字滤波器仿真软件的特点,提出了采用谱分析的方法进行可信性评估.以双线性变换法设计的IIR数字滤波器仿真软件的可信性评估为例,应用Matlab软件分别采用程序设计法、基于SPTool的频谱分析方法和基于Simulink的频谱分析方法实现了对数字滤波器仿真软件滤波结果的频谱分析.     

一种基于aacPlus音频的数字水印方法

本文提出了一种基于3G通信系统的音频数字水印算法.该方法针对3G移动通信技术的需要和特点,选用3G标准下的aacPlus音频格式作为载体,通过跳频频方法在音频载体的频域选取水印嵌入位置,并通过直接序列扩频方法对水印信息进行处理.实验结果表明此水印方法有较高的安全性和鲁棒性.