A NIR-II AIEgen-Based Supramolecular Nanodot for Peroxynitrite-Potentiated Mild-Temperature Photothermal Therapy of Hepatocellular Carcinoma

Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild-temperature PTT is a more promising antitumor strategy with much lower phototoxicity to neighboring normal tissues. However, the therapeutic efficacy of mild-temperature PTT is always restricted by the thermoresistance of cancer cells. To address this issue, a supramolecular drug nanocarrier is fabricated to co-deliver nitric oxide (NO) and photothermal agent DCTBT with NIR-II aggregation-induced emission (AIE) characteristic for mild-temperature PTT. NO can be effectively released from the nanocarriers in intracellular reductive environment and DCTBT is capable of simultaneously producing reactive oxygen species (ROS) and hyperthermia upon 808 nm laser irradiation. The generated ROS can further react with NO to produce peroxynitrite (ONOOˉ) bearing strong oxidization and nitration capability. ONOOˉ can inhibit the expression of heat shock proteins (HSP) to reduce the thermoresistance of cancer cells, which is necessary to achieve excellent therapeutic efficacy of DCTBT-based PTT at mild temperature (<50 °C). The antitumor performance of ONOOˉ-potentiated mild-temperature PTT is validated on subcutaneous and orthotopic hepatocellular carcinoma (HCC) models. This research puts forward an innovative strategy to overcome thermoresistance for mild-temperature PTT, which provides new inspirations to explore ONOOˉ-sensitized tumor therapy strategies.     

Intercalative Motifs-Induced Space Confinement and Bonding Covalency Enhancement Enable Ultrafast and Large Sodium Storage

Alloying-type metal sulfides with high theoretical capacities are promising anodes for sodium-ion batteries, but suffer from sluggish sodiation kinetics and huge volume expansion. Introducing intercalative motifs into alloying-type metal sulfides is an efficient strategy to solve the above issues. Herein, robust intercalative In S motifs are grafted to high-capacity layered Bi₂S₃ to form a cation-disordered (BiIn)₂S₃, synergistically realizing high-rate and large-capacity sodium storage. The In S motif with strong bonding serves as a space-confinement unit to buffer the volume expansion, maintaining superior structural stability. Moreover, the grafted high-metallicity Indium increases the bonding covalency of Bi S, realizing controllable reconstruction of Bi S bond during cycling to effectively prevent the migration and aggregation of atomic Bi. The novel (BiIn)₂S₃ anode delivers a high capacity of 537 mAh g⁻¹ at 0.4 C and a superior high-rate stability of 247 mAh g⁻¹ at 40 C over 10000 cycles. Further in situ and ex situ characterizations reveal the in-depth reaction mechanism and the breakage and formation of reversible Bi S bonds. The proposed space confinement and bonding covalency enhancement strategy via grafting intercalative motifs can be conducive to developing novel high-rate and large-capacity anodes.     

A Metal-Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme-Activity for Synergistic Treatment of Hypoxic Tumor

As a less O₂-dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia-induced low efficiency against solid tumors. However, the commonly used metal-involved agents suffer from the long-term biosafety concern. Herein, a metal-free type I photosensitizer, N-doped carbon dots/mesoporous silica nanoparticles (NCDs/MSN, ≈40 nm) nanohybrid with peroxidase (POD)-like activity for synergistic PDT and enzyme-activity treatment, is developed on gram scale via a facile one-pot strategy through mixing carbon source and silica precursor with the assistance of template. Benefiting from the narrow bandgap (1.92 eV) and good charge separation capacity of NCDs/MSN, upon 640 nm light irradiation, the excited electrons in the conduction band can effectively generate O₂^•− by reduction of dissolved O₂ via a one-electron transfer process even under hypoxic conditions, inducing apoptosis of tumor cells. Moreover, the photoinduced O₂^•− can partially transform into more toxic ^•OH through a two-electron reduction. Moreover, the POD-like activity of NCDs/MSN can catalyze the endogenous H₂O₂ to ^•OH in the tumor microenvironment, further synergistically ablating 4T1 tumor cells. Therefore, a mass production way to synthesize a novel metal-free type I photosensitizer with enzyme-mimic activity for synergistic treatment of hypoxic tumors is provided, which exhibits promising clinical translation prospects.     

Unveiling the Synergy of Interfacial Contact and Defects in α-Fe2O3 for Enhanced Photo-Electrochemical Water Splitting

Photo-electrochemical (PEC) water splitting is a promising method for converting solar energy into clean energy, but the mechanism of improving PEC efficiency through the interfacial contact and defect strategy remains highly controversial. Herein, reduced graphene oxide (rGO) and oxygen vacancies are introduced into α-Fe₂O₃ nanorod (NR) arrays using a simple spin-coating method and acid treatment. The resultant oxygen vacancy–α-Fe₂O₃/rGO-integrated system exhibits a higher photocurrent, four times than the pristine α-Fe₂O₃. It is well evidenced that the electronic interface interaction between α-Fe₂O₃ and rGO is boosted with the oxygen vacancies, facilitating electron transfer from α-Fe₂O₃ to rGO. Moreover, the oxygen vacancies not only create interband states in α-Fe₂O₃ that can trap photogenerated holes and thus facilitate charge separation but significantly also strengthen the adsorption of oxidative intermediates and reduce the energy barrier of rate-determining step during oxygen evolution reaction (OER). This study demonstrates an rGO–oxygen vacancy synergistic interfacial contact and defect modification approach to design semiconducting photocatalysts for high-efficiency solar energy capture and conversion. The generated principle is expected to be extendable to another material system.     

基于RDMA的区块传输机制设计与实现

随着区块链技术的不断发展,区块的传输延迟成为区块链系统可扩展性的性能瓶颈。远程直接内存访问（RDMA）技术能够支持高带宽和低时延的数据传输,为低延迟区块传输提供了新的思路。因此,结合RDMA原语的特性,设计了用于区块信息共享的区块目录结构,并在此基础上设计并实现了区块传输的基本工作过程。实验结果表明,相较于基于TCP的方案,在1 MB大小的区块上基于RDMA的区块传输机制将节点间的区块传输延迟降低了44%,全网络的区块传输延迟降低了24.4%,在10 000节点规模的区块链上,区块链发生临时分叉的数量降低了22.6%。可见,基于RDMA的区块传输机制充分发挥了高速网络的性能优势,降低了区块传输延迟及临时分叉的数量,提高了现有区块链系统的可扩展性。     

结合全局上下文与融合注意力的干涉相位去噪

目的 干涉相位去噪是合成孔径雷达干涉测量（interferometric synthetic aperture radar,InSAR）技术中的关键环节,其效果对测量精度具有重要影响。针对现有的干涉相位去噪方法大多关注局部特征以及在特征提取方面的局限性,同时为了平衡去噪和结构保持两者之间的关系,提出了一种结合全局上下文与融合注意力的相位去噪网络GCFA-PDNet(global context and fused attention phase denoising network)。方法 将干涉相位分离为实部和虚部依次输入到网络,先从噪声相位中提取浅层特征,再将其映射到由全局上下文提取模块和融合注意力模块组成的特征增强模块,最后通过全局残差学习生成去噪图像。全局上下文提取模块能提取全局上下文信息,具有非局部方法的优势;融合注意力模块既强调关键特征,又能高效提取隐藏在复杂背景中的噪声信息。结果 所提出的方法与对比方法中性能最优者相比,在模拟数据结果的平均峰值信噪比（peak signal to noise ratio, PSNR）和结构相似性（structural similarity,...     

Extended state observer-based finite-region control for 2-D Markov jump systems

In this article, an extended state observer-based finite-region control scheme is presented for two-dimensional Markov jump systems with unknown mismatched disturbances. The mathematical model of the two-dimensional Markov jump systems is built on the well-known Roesser model. By establishing special recursive formulas and utilizing the 2-D Lyapunov function theory, sufficient conditions are obtained, which prove that the resultant system is finite-region bounded, if some linear matrix inequalities are achieved. Then, we provide an algorithm to solve the extended state observer-based controller gains. With the proposed control scheme, the external disturbances can be actively rejected from the system outputs. To conclude, a numerical example based on the Darboux equation is provided to demonstrate the validity and effectiveness of the devised control scheme.     

基于多特征融合的无监督真值发现方法

真值发现是数据集成领域具有挑战性的研究热点之一。传统的方法利用数据源与观测值之间的交互关系推断真值,缺乏足够的特征信息;基于深度学习的方法可以有效地进行特征抽取,但其性能依赖于大量手工标注,而在实际应用中很难获取到大量高质量的真值标签。为克服以上问题,本文提出一种基于多特征融合的无监督真值发现方法（Unsupervised truth discovery method based on multi-feature fusion, MFOTD）。首先,利用集成学习无监督标注“真值”标签;然后,分别使用预训练模型 Bert和独热编码获取观测值的语义特征和交互特征;最后,融合观测值多种特征并使用其“真值”标签构建初始训练集,通过自训练方式训练真值预测模型。在两个真实数据集上的实验结果表明,与已有方法相比,本文所提出的方法具有更高的真值发现准确性。     

图像边缘权重优化的最小生成树分割提取

针对无监督图像分割方法对噪声敏感而导致图像建模困难、分割结果准确率低等问题,该文提出一种图像边缘权重优化的最小生成树分割提取方法。首先,利用L0梯度最小值平滑处理噪声再结合Otsu优化Canny边缘检测,得到更加准确的边缘信息;其次,重新设计权重函数,采用更加合理的色差空间构建加权图,通过改进分割准则优化物体合并与区分过程;最后,选择不同类型图片进行抗噪性、分割效果实验。实验结果表明：相对于其他算法,该文算法的抗噪性能优秀,分割精度平均提升5.15%,过分割率平均下降32.07%,欠分割率平均下降2.69%。将其运用在实际航空遥感图像的河道湖泊提取中,所得结果相比其他主流算法结构更加完整,无关信息更少,抗噪性能更好。     

机载多维度SAR航空观测系统实验初步进展

随着合成孔径雷达(SAR)技术的发展,从极化、频率、角度和时相等多个维度空间联合观测成为SAR发展的重要趋势,但维度联合观测的系统与实验少有报道。该文概要介绍了机载多维度SAR(MSJosSAR)航空观测系统的能力,归纳总结了该系统的技术特点。提出多维度SAR一致性成像方法,实现多波段成像后的配准精度优于1个像元。分析了多波段极化角度特征谱、多方位角层析3维结构重建、多时相相干变化检测等3种SAR多维观测量的初步实验结果,验证了系统的多维观测能力。