Transdermal Iontophoretic Delivery of Thyrotropin-Releasing Hormone Across Excised Rabbit Pinna Skin

Enhanced transport of a model peptide drug thyrotropin-releasing hormone (TRH), a tripeptide of molar mass 362 g and a pK_a 6.2, through excised rabbit pinna skin was achieved by means of iontophoresis with continuous current or monophase periodically pulsed current. The resulting flux in the steady state was proportional to the applied current density. In the transdermal iontophoretic delivery of TRH, the pulsed iontophoretic flux exceeded that obtained with a continuous current. At a low ionic strength, an increased degree of protonation in TRH increased the rate of permeation. The flux of TRH in a buffer at pH 4 is greater than that at pH 8 when the ionic strength is 0.1 M. At a greater ionic strength, the trend is reversed. The enhanced flux of unprotonated TRH during transdermal iontophoresis is attributed largely to electro-osmotic volume flow. An increased rate of permeation of TRH crossing the skin is achieved at low ionic strength, moderate pH, and a large duly cycle of current; the frequency of pulsed current had no significant influence on the rate of transdermal iontophoretic delivery of TRH.     

Analysis of dispersion characteristics for a circular dielectric waveguide with periodic metallic strips by using the method of lines

The dispersion characteristics of circular dielectric waveguide with periodic metallic strips are analyzed by the method of lines. The filter property of the metallic strip loaded structure is carefully investigated for both TE and TM modes. The brillioum diagrams for both TE₀₁ and TM₀₁ modes are given. A comparison is made between the results obtained by Galerkin's method and those calculated with the method of lines, and very good agreement has been found; the accuracy of the present method is thus justified. On the basis of the analysis, some useful guidelines for the design of the bandreject filters are suggested.     

PAA-PSF交联复合膜的制备及对低浓度有机醇水溶液反渗透分离性能研究

进行了ＰＡＡ（ＰｏｌｙａｃｒｙｌｉｃＡｃｉｄ）－ＰＳＦ（Ｐｏｌｙｓｕｌｆｏｎｅ）交联复合膜的制备，研究了交联剂、添加剂对膜性能的影响，并通过扫描电镜观察了膜的断面结构．研究了ＰＡＡ－ＰＳＦ交联复合膜对低浓度有机醇类水溶液反渗透分离性能．发现对于１０００×１０－６乙醇水溶液截留率达到６６．２％，透过流束可达０．９×１０－６（ｍ３·ｍ－２·ｓ－１）．随醇的分子量的增加，截留率不断上升，对戊醇的截留率达９４．３％，而透过流束则保持相对稳定．对不同结构醇类的分离性能研究表明，截留率存在有：ｔｅｒｔ－＞ｓｅｃ－＞ｉｓｏ－＞ｎ－的规律．     

激光扫描共焦荧光显微镜的电子控制系统研究

介绍了激光扫描共焦荧光显微镜的电子控制系统，为了提高激光扫描器的定位精度，在系统中提出采用基于闭环象素时钟发生器的检流计振镜所固有的扫描非线性失真补偿方案，减少输出图象的枕形畸变，实现行扫描空间位置的均匀性。在以细分梯形波电流驱动反应式步进电机情况下，根据实测θｉ曲线，用反插法求得与步进电机运行非均匀性相补偿的相电流波，从而获得在小电流情况下高角度均匀的步进电机细分运行特性。     

Why spin = 1, 2 species have no electron paramagnetic resonance signal under normal conditions: possible detection by electron paramagnetic resonance at frequency close to D value?

A universal EPR simulation program has been created by the author, which is based on the following spin Hamiltonian equation: [equation: see text] where D and E are the axial and rhombic zero-field splitting parameters, respectively. The program can be used for simulation of EPR spectra with half-integer electronic spin (S = n/2, n = 3, 5, 7, 9) systems. In this article, the integer spin (S = n/2, n = 2, 4) systems are also considered. The EPR simulation results show that when D > frequency, no EPR signal can be seen from EPR simulation; when D approximately frequency, whichever X/Q/W-band is used, the EPR signal can be seen on the basis of the simulated EPR results presented.     

On the J-integral in periodically layered composites

When a heterogeneous elastic material is represented by an effective homogeneous elastic solid, average stress and strain fields are used. The meaning of the J-integral in the effective homogeneous solid is investigated. A periodically layered medium is considered. The relation between the J-integrals in the original layered medium and the effective medium is derived.     

An anthropocentric approach to knowledge-based preventive maintenance

It is common knowledge today that application of sound manufacturing concepts and techniques will only provide cost-effective, long-term return when manufacturing functions are totally integrated with the operators, maintenance engineers and other associated personnel. This paper presents a human-centred methodology and its associated knowledge-based tool, to utilize equipment failure information for the purpose of machine down-time minimization. Based upon a structured and rigorous assessment of each breakdown, and combined with total employee participation, continuous improvement of maintenance function and operational effectiveness of equipment can be made a reality.     

捷克5500m^3／min轴流式高炉鼓风机叶片损坏原因及分析

就５５００ｍ＾３／ｍｉｎ高炉鼓风机动，静叶片损坏事故发生的经过以及有关资料，从几个方面详细分析了事故发生的原因。