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101.
Epidemiological studies have linked dietary fiber to the prevention of human colorectal cancer and suggest that short chain fatty acids such as butyric acid, which is produced by fermentation of dietary fiber in the large intestine, may be an important mediator of the protective effects of fiber. We investigated the role of Bcl-2 deregulation on the sensitivity of colorectal carcinoma cells to undergo butyrate-induced apoptosis. Here we report an inverse relationship between the levels of Bcl-2 and the sensitivity of colorectal carcinoma cell lines to undergo apoptosis in response to butyrate. Overexpression of Bcl-2 in colorectal carcinoma DiFi cells resulted in suppression of butyrate-induced apoptosis and enhanced cell survival in response to butyrate. Butyrate-induced apoptosis was accompanied by inhibition of expression of a 30 kDa protein (p30, immunorecognized by anti-Bcl-2 mAb) and this cellular effect of butyrate was inhibited by Bcl-2 overexpression. These findings suggest that deregulation of Bcl-2 in human colorectal carcinoma cells confers resistance to induction of apoptosis by butyrate, a dietary micronutrient. 相似文献
102.
Chih-Chun Hsieh Tao-Chih Chang Dong-Yih Lin Ming-Che Chen Weite Wu 《Metals and Materials International》2007,13(5):411-416
The purpose of this study is to investigate the precipitation characteristics of σ phase in the fusion zone of stainless steel
welds at various welding passes during a tungsten are welding (GTAW) process. The morphology, quantity, and chemical composition
of the δ-ferrite and σ phase were analyzed using optical microscopy (OM), a ferritscope (FS), a X-ray diffractometer (XRD),
scanning electron microscopy (SEM), an electron probe micro-analyzer (EPMA), and a wavelength dispersive spectrometer (WDS),
respectively. Massive δ-ferrite was observed in the fusion zone of the first pass welds during welding of dissimilar stainless
steels. The σ phase precipitated at the inner δ-ferrite particles and decreased δ-ferrite content during the third pass welding.
The σ and δ phases can be stabilized by Si element, which promoted the phase transformation of σ→ϱ+λ2 in the fusion zone of the third pass welds. It was found that the σ phase was a Fe−Cr−Si intermetallic compound found in
the fusion zone of the third pass welds during multi-pass welding. 相似文献
104.
105.
We have made reasonably comprehensive measurements of action potential activity in the Aplysia californica abdominal ganglion to determine the amount of feedback the central nervous system (CNS) receives from a movement which it initiates. Voltage-sensitive dye measurements of action potential activity of cells in the ganglion were made during the gill-withdrawal reflex elicited by siphon stimulation. We compared recordings in two situations which differed dramatically in the amount the gill moved. In the control sea water, the gill withdrawal was normal; in low-Ca2+, high-Mg2+ sea water, the gill movement was blocked. Both the timing and the number of spikes of the individual neurons were similar in the two situations. Histograms of the summed spike activity versus time and histograms of the number of active neurons versus time in the two conditions were also similar. Finally, two numerical measures of trial-to-trial differences, a paired t-test and a measure we named fractional similarity, did not indicate larger differences between two trials in the different sea waters than two trials in the same sea water. Feedback from sensory neurons activated by the gill movement itself does not make a large contribution to the spike activity in the abdominal ganglion. Apparently the Aplysia CNS issues the command for the withdrawal and does not make adjustments for the magnitude of the actual withdrawal. It may not even receive the information necessary for such adjustments to be made. A second motivation for these experiments was to test whether removing the feedback might simplify the neuronal activity that occurs during the gill-withdrawal reflex. This did not occur. 相似文献
106.
107.
研究了55SiMnVB弹簧钢板疲劳断口特征及裂扩展过程。结果表明,喷丸强化在表层产生的残余压应力可明显提高疲劳抗力,增强裂纹闭合效应,降低裂纹扩展速度。 相似文献
108.
109.
智能测温仪表的研究与实现 总被引:1,自引:0,他引:1
文章介绍了一种以8098单片机为核心、以铂铑一铂为测温元件研制的智能化测温仪表,它与传统的接触式温度传感器相比具有价格低、性能高、应用范围广、人机界面好等特点。 相似文献
110.
In order to overcome the limitations of previous columnar-to-equiaxed (CET) models, which neglect melt convection and the
movement of free equiaxed grains, this article presents a three-phase deterministic CET model. With appropriated multiphase
volume-averaging approaches, it is possible to account for nucleation and growth of equiaxed grains ahead of a growing columnar
front, the influence of melt convection, and grain sedimentation, and the occurrence of a CET in a casting of engineering
scale. Special modeling assumptions ensure that both CET mechanisms, namely, “hard” and “soft” blocking, are tackled. It is
highly recommended that both mechanisms should be considered, especially in the situation where grain sedimentation and melt
convection are present. Although the current model incorporates almost all the physical variables relevant to a CET event,
under special condition of a one-dimensional case, the model still reproduces the results of Hunt’s classical CET approach.
This article is based on a presentation made in the symposium entitled “Solidification Modeling and Microstructure Formation:
In Honor of Prof. John Hunt,” which occurred March 13–15, 2006, during the TMS Spring Meeting in San Antonio, Texas, under
the auspices of the TMS Materials Processing and Manufacturing Division, Solidification Committee. 相似文献