p53 codon 72 polymorphism in Taiwanese lung cancer patients: association with lung cancer susceptibility and prognosis

Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues. We have now assessed the effect of this agent in vivo on the nasal epithelium of CF mutant mice and also in the nose and lungs of human subjects with CF. Wild-type mice showed a small hyperpolarization of the nasal potential difference (PD) in response to milrinone (100 microM, 1.6 +/- 0.6 mV, n = 8, P < 0.05). In contrast, CF mice carrying either the most common human mutation of the gene for the CF transmembrane regulator (CFTR), DeltaF508 (protein mislocalized), or the G551D mutation (protein normally localized) failed to demonstrate this response. Milrinone perfused alone had no significant effect on the baseline nasal PD of human subjects without CF (14.7 +/- 4.0 mV preperfusion; 15.3 +/- 4.6 mV postperfusion), but significantly (P < 0.05) augmented the hyperpolarization induced by a subsequently perfused low-chloride solution (with milrinone, 36.8 +/- 3.0 mV, n = 6; without milrinone, 18.1 +/- 2.2 mV, n = 19). In contrast, in human subjects with CF (n = 6), milrinone alone significantly (P < 0. 05) altered the nasal baseline PD (52.2 +/- 3.3 mV preperfusion; 57. 4 +/- 4.2 mV, postperfusion) but not the subsequent responses to the low-chloride solution (with milrinone, 1.1 +/- 2.2 mV, n = 4; without milrinone, 0.6 +/- 0.5 mV, n = 28) or to isoproterenol (100 microM). In a separate study in subjects (n = 6) with the DeltaF508 mutation, nasal coadministration of milrinone with isoproterenol produced no effect in the presence of amiloride and a low-chloride solution (-0.8 +/- 0.5 mV). This was also the case in the nasal epithelium of CF subjects (n = 4) carrying at least one G551D allele (-0.3 +/- 0.8 mV). Similarly, milrinone did not hyperpolarize the PD of either the tracheal (n = 6) or segmental (n = 6) airways of CF subjects (DeltaF508) when applied topically in vivo in the presence of amiloride, isoproterenol, or adenosine triphosphate (all 100 microM) in a low-chloride solution. These data do not support the use of milrinone to induce chloride secretion in CF airways in vivo.     

Thermodynamic Study on the Rare Earth Vapour Complex PrAl_3Cl_(12)

ＴｈｅｒｍｏｄｙｎａｍｉｃＳｔｕｄｙｏｎｔｈｅＲａｒｅＥａｒｔｈＶａｐｏｕｒＣｏｍｐｌｅｘＰｒＡｌ３Ｃｌ１２ＷａｎｇＬｉｎｓｈａｎ（王林山），ＧａｏＲｏｎｇｊｉｅ（高荣杰），ＳｕＹｉ（苏轶），ＷａｎｇＺｈｉｃｈａｎｇ（王之昌）（Ｄｅｐａｒｔｍｅｎｔ...     

基于西门子数字驱动伺服611U 的钢轨锯钻床控制系统

近年来,我国铁路客运专线的建设得到高速发展,对钢轨质量提出了更高要求,对钢轨定尺的准确性和钻孔的质量要求也越来越高,通过采用西门子数字驱动伺服611U装置结合上位机PLC系统的步序逻辑控制,能够很好的完成钢轨的定尺和锯钻,大大提高了产品的加工精度.     

炮塔加热过程数学模型与计算机仿真研究

通过对炮塔热处理加热过程的分析研究,取局部最大壁厚处作为二维非稳定态传热问题进行离散化处理,建立了工件加热过程显式有限差分仿真模型。并对计算机仿真结果与实测数据进行了比较验证。     

具有边梁的悬臂矩形板的弯曲问题

本文建议一个求解具有边梁悬臂矩形板弯曲问题的解析解法。该法将有边梁和无边梁悬臂矩形板弯曲问题的解融为一体,在有边梁悬臂矩形板的解中令边梁弯曲刚度为零即得到无边梁悬臂矩形板的解。     

拔染剂的应用性能研究

综合分析了三种拔染剂在拔染浆中的稳定性、吸湿性和渗透性等应用性能，并得出一些重要结论。     

水压引信目标分类的研究

本文提出一种模糊统计分类 FSC 方法,用于研究水压引信目标分类问题。在建立水面目标场多级网络分类模型的基础上,分析讨论了此方法的特征提取、识别函数、模糊与冲突、搜索算法等技术问题,并通过仿真实验,对水面目标航速、吨位、横距进行分类处理,结果表明,FSC 方法行之有效。     

ZL205A高强度铝铜合金的铸造及热处理

探讨了ＺＬＮ２０５Ａ高强度铝铜合金的铸造性能和热处理工艺方法，阐述了ＺＬ２０５Ａ铝铜合金在Ｔ５热处理时，如何才能达到机械性能的工艺方法。     

有一个紧固件的半无限板孔周应力有限元分析

用有限元法计算了有一个紧固件孔的半无限平板在紧固件力作用下的孔周应力．在紧固件与孔之间的接触区域的结点间加无长刚杆元．用反复计算的方法确定接触范围；计算出孔周应力等，并与文献［１］的实验结果进行了比较．