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排序方式: 共有10000条查询结果,搜索用时 343 毫秒
91.
92.
SI Chowdhury BJ Lee D Mosier JH Sur FA Osorio G Kennedy ML Weiss 《Canadian Metallurgical Quarterly》1997,117(4):295-310
CI-994 (acetyldinaline) is an orally active anticancer drug currently in Phase 1 clinical trials. To assess its preclinical toxicity, CI-994 was administered orally as suspensions to Wistar rats (10/sex/dose) and in capsules to beagle dogs (3/sex/dose) once daily for two weeks. Doses were 1.5, 5, and 15 mg/kg for rats (9, 30, and 90 mg/m2, respectively), and 0.5, 2, and 5 mg/kg for dogs (10, 40, and 100 mg/m2, respectively). Systemic exposure was dose-proportional based on toxicokinetic analysis in dogs. Severe clinical signs and mortality occurred at the highest dose in both species beginning on Day 10. Neutropenia, lymphocytopenia, thrombocytopenia, lymphoid depletion, bone marrow hypocellularity, and testicular degeneration were observed in both species, primarily at the mid- and high-doses. Despite continued treatment, neutrophil counts in dogs returned to control levels in Week 2. Other microscopic findings in rats included splenic hematopoietic depletion at all doses and epithelial cell necrosis in various tissues at 15 mg/kg. Additional bone marrow changes in dogs involved myeloid and megakaryocyte hyperplasia at 2 mg/kg and abnormal myeloid and megakaryocyte maturation at 2 and 5 mg/kg. Except for the testicular effects in both species, all changes were reversible within a 4-week (rat) or 9-week (dog) recovery period. The results of these studies show that target organ effects of CI-994 principally involve tissues with rapidly dividing cell populations and that bone marrow suppression is the dose-limiting toxicity. CI-994 also seems to interfere with the release and/or maturation of cells in the bone marrow. 相似文献
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介绍了在红外系统中,采用步进电机作为扫描机构驱动元件,以D/A数模转换器作细分方式的定频脉宽调制驱动方式,实现微机控制下的扫描机的构步距均匀稳定,满足红外系统分辨率的要求。 相似文献
96.
Y. Yang B. F. Wang J. Xiong Y. Zeng Z. P. Chen X. Y. Yang 《Metallurgical and Materials Transactions A》2006,37(10):3131-3137
The microstructure and microtexture in adiabatic shear bands (ASBs) on the titanium side in the titanium/mild steel explosive
cladding interface are investigated by means of optical microscopy, scanning electron microscopy/electron backscattered diffraction
(SEM/EBSD), and transmission electron microscopy (TEM). Highly elongated subgrains and fine equiaxed grains with low dislocation
density are observed in the ASBs. Microtextures (25 deg, 75 deg, 0 deg), (70 deg, 45 deg, 0 deg), and (0 deg, 15 deg, 30 deg)
formed within the ASBs suggest the occurrence of the recrystallization. The grain boundaries within ASBs are geometrically
necessary boundaries (GNBs) with high angles. Finite element computations are performed to obtain the effective strain and
temperature distributions within the ASBs under the measured boundary conditions. The rotation dynamic recrystallization (RDR)
mechanism is employed to describe the kinetics of the nanograins’ formation and the recrystallized process within ASBs. During
the deformation time (about 5 to 10 μs), the following processes take place: dislocations accumulate to form elongated cell
structures, cell structures break up to form subgrains, and subgrains rotate and finally form recrystallized grains. The small
grains within ASBs are formed during the deformation and do not undergo significant growth by grain boundary migration after
deformation. 相似文献
97.
本文研究了背景噪声限下采用编码的直接检测光PPM系统的性能,分析了具有不同码率的采用硬判决译码的RS码,采用最大似然(ML)译码的卷积码的性能及未编码的PPM系统的性能,给出了相应的误比特率和每信息比特信噪比的关系曲线。结果表明:对背景噪声限下的直接检测光PPM系统,随着码率的降低,编码不一定能改善系统性能。 相似文献
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99.
网带式连续烧结炉炉温及网带速度微机控制系统 总被引:1,自引:0,他引:1
本文介绍一个基于STD总线的单片机网带式连续烧结炉炉温及网带速度控制系统,详细叙述了系统的硬件结构和控制算法。 相似文献
100.