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排序方式: 共有326条查询结果,搜索用时 13 毫秒
321.
Nrusingh Charan Pradhan Pramod Kumar Sahoo Dilip Kumar Kushwaha Yash Makwana Indra Mani Mohit Kumar Aruna T N Soumya Krishnan V 《野外机器人技术杂志》2023,40(6):1543-1561
Agricultural tractor drivers are subjected to high levels of whole-body vibrations and hand arm vibrations during most part of the farm activities due to unevenness of field surface, uneasy posture, improper workplace design, moving parts of the tractor, and other unavoidable circumstances. The comfort level of the operator inside a dynamic tractor is dependent on the level of vibration generated inside the different human body segments. In the present study, a finite element modeling was proposed to predict vertical vibrations (Z-axis) and frequencies at the different body segments of the seated small tractor operator. The forces required for different controls of the tractor were measured to be used as input parameters in the finite element modeling. The maximum mean forces of the brake (172.8 N) and clutch (153.2 N) were used as the input parameters for the simulation study. The simulated results were validated with the field measured values of vertical accelerations at selected body segments of the operator. The simulation could successfully predict vertical vibrations at selected points of interest (i.e., foot, leg, thigh, lower arm, upper arm, back, and head) except the chest of the body, as the buttock of the operator model was fixed (degree of freedom is equal to zero) in the simulation. The obtained results were compared with the international standards ISO 2631-1 (1985/1997) and ISO 5349-1 (2001) to assess the vibration characteristics at the different body segments of the operator. The foot, leg, lower arm, and upper arm of the operator were subjected to vertical vibration frequencies from 10 to 200 Hz. Most of the resonance of vertical accelerations occurred in one-third octave bands of 20–80 Hz frequencies. The thigh, chest, back, and head of the operator were exposed to vibration frequencies below 40 Hz during field operation. At these parts of the body, the vertical acceleration resonated at lower frequencies, between 2 and 8 Hz. 相似文献
322.
Aiswarya Samal Anoop Kumar Kushwaha Debashish Das Mihir Ranjan Sahoo Nicholas A. Lanzillo Saroj Kumar Nayak 《Advanced Engineering Materials》2023,25(13):2201192
Copper-graphene (Cu/Gr) composite carries high thermal (κ) and electrical (σ) conductivities compared with pristine copper film/surface. For further improvement, strain is applied (compressive and tensile) and thickness is changed (of both copper and graphene). It is observed that electronic thermal conductivity (κe) and σ enhance from 320.72 to 869.765 W mK−1 and 5.28 × 107 to 23.01 × 107 S m−1, respectively, by applying 0.20% compressive strain. With the increase in copper thickness (three to seven layers) in Cu(111)/single-layer-graphene (SLG) heterosystem, κe increases from 320.72 to 571.81 W mK−1 while electrical resistivity (ρ ∝ (1/σ)) decreases from 0.189 × 10−7 to 0.117 × 10−7 Ωm. Furthermore, with the increase in graphene thickness (one to four layers) in seven-layer Cu(111)/multilayer-graphene (MLG) heterosystem, κe enhances upto 126% while ρ decreases upto 70% compared with the three-layer Cu(111)/SLG. A large available state near Fermi level (of Cu/Gr heterosystem) offers the conduction of more electrons from valence to conduction bands. The increasing thickness broadens this state and enhances conduction electrons. The electron localization function decreases with increasing thickness, suggesting electrons are delocalized at copper-graphene junction, resulting in an increase of free electrons that enhance κe and σ. Herein, it is useful in advancing the thermal management of electronic chips and in applying hybrid copper-graphene interconnects. 相似文献
323.
Ashish Kumar Yadav Narendra Kumar Abdul Talim Khan Rajesh Kushwaha Dr. Samya Banerjee 《ChemMedChem》2022,17(2):e202100615
In recent years, to overcome the problem of low tissue penetration power of light in photodynamic therapy (PDT), sonodynamic therapy (SDT) with ultrasound (US) as the drug stimulus has emerged as a potential alternative to PDT. The significantly higher tissue penetration capacity of US is reported to allow the treatment of deep-seated tumours. In general, organic molecules and nanomaterials dominate as the sonosensitizers in this area of research, and the potential of metal complexes in SDT is not yet well explored. In this highlight, we have summarized two recent literature reports in which researchers have explored the efficiency of metal complexes as sonosensitizers for the first time. These reports indicate the high potential of metal complexes in SDT. 相似文献
324.
Ashish Kumar Yadav Virendra Singh Rajesh Kushwaha Dr. Dependu Dolui Rohit Rai Dr. Prodyut Dhar Dr. Arnab Dutta Dr. Biplob Koch Dr. Samya Banerjee 《Chembiochem : a European journal of chemical biology》2023,24(10):e202300033
Four new CoII complexes, [Co(bpy)2(acac)]Cl ( 1 ), [Co(phen)2(acac)]Cl ( 2 ), [Co(bpy)2(cur)]Cl ( 3 ), [Co(phen)2(cur)]Cl ( 4 ), where bpy=2,2’-bipyridine ( 1 and 3 ), phen=1,10-phenanthroline ( 2 and 4 ), acac = acetylacetonate ( 1 and 2 ), cur=curcumin monoanion ( 3 and 4 ) have been designed, synthesized and fully characterized. The X-ray crystal structures of 1 and 2 indicated that the CoN4O2 core has a distorted octahedral geometry. The photoactivity of these complexes was tuned by varying the π conjugation in the ligands. Curcumin complexes 3 and 4 had an intense absorption band near 435 nm, which made them useful as visible-light photodynamic therapy agents; they also showed fluorescence with λem≈565 nm. This fluorescence was useful for studying their intracellular uptake and localization in MCF-7 breast cancer cells. The acetylacetonate complexes ( 1 and 2 ) were used as control complexes to understand the role of curcumin. The white-light-triggered anticancer profiles of the cytosol targeting complexes 3 and 4 were investigated in detail. These non-dark toxic complexes displayed significant apoptotic photo-cytotoxicity (under visible light) against MCF-7 cells through ROS generation. The control complexes 1 and 2 did not induce significant cell death in the light or dark. Interestingly, 1-4 produced a remarkable antibacterial response upon light exposure. Overall, the reported results here can increase the boundary of the CoII-based anticancer and antibacterial drug development. 相似文献
325.
Anyi Dao Rajesh Kushwaha Ashish Kumar Dr. Huaiyi Huang Dr. Samya Banerjee 《ChemMedChem》2022,17(10):e202200119
Photodynamic therapy (PDT), a non-/minimally invasive cancer treatment method, has the advantages of low side effects, high selectivity, and low drug resistance. It is currently a popular cancer treatment method. However, given the shortcomings of photosensitizers such as poor photostability, poor water solubility, and short half-life in vivo when used alone, the development of photosensitizer nano-delivery platforms has always been a research hotspot to overcome these shortcomings. In the human body, various types of cells generally release bilayer extracellular vesicles known as exosomes. Compared with traditional materials, exosomes are currently an ideal drug delivery platform due to their homology, low immunogenicity, easy modification, high biocompatibility, and natural carrying capacity. Therefore, in this concept, we focus on the research status and prospects of engineered exosome-based photosensitizer nano-delivery platforms in cancer PDT. 相似文献
326.
Arif Ali Mandal Rajesh Kushwaha Ashish Kumar Yadav Dr. Samya Banerjee 《Chembiochem : a European journal of chemical biology》2023,24(6):e202200597
Sonodynamic therapy (SDT) for cancer treatment is gaining attention owing to its non-invasive property and ultrasound‘s (US) deep tissue penetration ability. In SDT, US activates the sonosensitizer at the target deep-seated tumors to generate reactive oxygen species (ROS), which ultimately damage tumors. However, drawbacks such as insufficient ROS production, aggregation of sonosensitizer, off-target side effects, etc., of the current organic/nanomaterial-based sonosensitizers limit the effectiveness of cancer SDT. Very recently, metal complexes with tunable physiochemical properties (such as sonostability, HOMO to LUMO energy gap, ROS generation ability, aqueous solubility, emission, etc.) have been devised as effective sonosensitizers, which could overcome the limitations of organic/nanomaterial-based sonosensitizers. This concept introduces all the reported metal-based sonosensitizers and delineates the prospects of metal complexes in cancer sonodynamic therapy. This new concept of metal-based sonosensitizer can deliver next-generation cancer drugs. 相似文献