Oral absorption improvement of poorly soluble drug using solid dispersion technique

A new triazol antifungal agent, (+)-2-(2,4-difluorophenyl)-3-methyl-1-(1H-1, 2,4-triazol-1-yl)-3-[6-(1H-1,2,4-triazol-1-yl)pyridazin++ +-3-ylthio]butan-2-ol (MFB-1041), shows poor oral absorption and is practically insoluble in water (1.2 micrograms/ml). Solid dispersion systems with an enteric polymer such as hydroxypropylmethylcellulose phthalate (HP-55) and carboxymethylethylcellulose (CMEC), and a nonenteric polymer, hydroxypropylmethylcellulose (Metolose) were evaluated to improve drug absorption and solubility. The oral bioavailabilities of these solid dispersions in beagle dogs were over 6 times higher than that of a suspension system with increasing drug solubility in an alkaline medium. X-Ray powder diffraction measurement of the solid dispersion showed a complete drug phase change from a crystal to an amorphous state. Further, from the results of a stability test, the preparations were stable in a desiccated condition and the absorption profiles also showed no change. From the results, it was suggested that the oral administrative preparation of MFB-1041 having a superior absorption profile and a high stability could be obtained by a drug phase change from a crystal to an amorphous state, especially in the spray-drying method using enteric polymers.     

Discrimnation Of Equilibrium Moisture Equations For Soybean Usmg Nonlinearity Measures

The main goal of this work is to find the best way to represent the equilibrium conditions between soybean and air. The experimental study was based on the static method using saturated salt solutions in order to regulate the vapour pressure of the air surrounding the grains. We developed a discrimination study among some ensting equations used for grains. To discriminate these equations we explored some non-linearity measures. The obtained results showed that the Halsey modified equation was the best model in terms of nonsignifiance for bias and non-linearity measures. The distribution for the estimated parameters. using simulation procedures, also showed good normal behavior for the Halsey equation.     

The merits of varicella vaccination for varicella non-immune health care workers

Immunity against varicella can be reliably established by history and, if negative, confirmed or refuted by serology. If non-immune, the merits of varicella vaccine for a health care worker (HCW) can be stated clearly: Protection from a disease which may be particularly severe in an adult, and evading the inconvenience (investigation time and possible work restriction) and cost of managing an exposure. This paper discusses implementation of a varicella immunity program for HCWs at Columbia Presbyterian Hospital in Oklahoma City.     

Equivalence between Ampere and Grassmann's forces

We calculate the force on part of a single closed circuit due to the remaining circuit in four different geometries according to the forces of Ampere and Grassmann. All analytical calculations are performed using surface or volume current elements in order to avoid the divergences which appear with linear current elements of zero diameter. We conclude that when we consider the action of a closed circuit as a whole and utilize only circuits with closed lines of current, there will be an equivalence between the expressions of Grassmann and Ampere. This means that both of them are compatible with the experimental findings related to Ampere's bridge, contrary to the opinion of some authors     

Twisted axially loaded rod with shear and compressibility

Summary Stability of a twisted and axially compressed elastic rod is analysed using the Euler method of adjacent equilibrium configuration. The constitutive equations of the rod are assumed in the form that takes into account both shear of the cross-sections and compressibility of the rod axis. It is shown that bifurcation points of the non-linear system of equations describing equilibrium are determined from the linearized system of equations. The influence of shear and compressibility on the critical values of twisting couple and compressive force is obtained. Moreover, the bifurcation pattern is examined by using the Liapunov-Schmidt method.     

Critical enhancement of the in-medium nucleon-nucleon cross section at low temperatures

As part of an 18-month carcinogenicity study, 680 Syrian hamsters (Mesocricetus auratus) received daily gavage doses of fenazaquin, an experimental miticide. Mortality associated with severe enteritis was noticed beginning when the hamsters were 4 months old and ranged from one to five deaths per month until the hamsters were about 10 months old, when 41 deaths occurred in a 1-month period. Ante- and postmortem findings were consistent with those reported for antibiotic-induced enteritis in hamsters. Clostridium difficile was isolated from 12 of the 13 samples of cecal contents analyzed. Toxin assays of C. difficile isolates collected from 11 affected animals were positive for both cyto- and enterotoxins. Daily oral administration of vancomycin hydrochloride at a dose of 20 mg/kg was initiated when the hamsters were about 10 months old. Deaths due to C. difficile enteritis were significantly decreased within 2 weeks, and treatment was continued for 3 months. A trial withdrawal period for a subset of 64 hamsters (approximately 16% of the total population) was initiated to evaluate survival after discontinuation of the antibiotic treatment. Clostridium difficile enteritis recurred within 2 weeks and caused 19 deaths during the next month; therefore, these hamsters were returned to daily vancomycin treatment for the remainder of the study. With the exception of severe gaseous distention of the ceca, which caused death in 17 (< 4% of the total population) of the affected hamsters, vancomycin treatment did not cause any major adverse effects.(ABSTRACT TRUNCATED AT 250 WORDS)     

Three-node, 40 Gbit/s OTDM network experiment using electro-opticswitches

The authors demonstrate, for the first time, a three node optically time division multiplexed network with a maximum capacity of 40 Gbit/s. Electro-optical switches were used for both `drop and insert' and demultiplexing, and electronic clock recovery provided synchronisation throughout the network