Significant reduction of medical costs by differentiation therapy with all-trans retinoic acid during remission induction of newly diagnosed patients with acute promyelocytic leukemia. The Japan Adult Leukemia Study Group

OBJECTIVE: For resuscitation of hemorrhagic hypovolemia, we compared the effectiveness of (1) isotonic lactated Ringer's solution (LRS), (2) 2400 mOsm of 7.5% NaCl:6% dextran 70 (HSD), and (3) 2400 mOsm of 7.9% sodium acetate:1.9% NaCl:6% dextran 70 (HAD). DESIGN: In six randomized, blinded experiments for each solution, conscious instrumented adult sheep were hemorrhaged by removing approximately 1.8 L (42 +/- 3 mL/kg) of blood, while maintaining the mean arterial pressure (MAP) at 50 mm Hg for 2 hours. METHODS: Test solutions were infused as needed to restore the cardiac index to baseline. RESULTS: Volume requirements with HAD (236 +/- 29 mL) and HSD (244 +/- 39 mL) were significantly less (p < 0.05) than LRS (3463 +/- 234 mL). Mean arterial pressure was normalized with HSD and LRS, but not with HAD, which resulted in MAPs of 20 to 25 mm Hg less than baseline resulting from a reduced peripheral resistance. Oxygen delivery, however, was significantly higher with HAD during the resuscitation period. Acid-base balance (pH) and oxygen consumption were normalized within 5 minutes of infusion only with HAD. CONCLUSIONS: Small-volume infusion with HAD resulting in "high-flow-low-pressure" resuscitation may offer unique hemodynamic and metabolic advantages for the initial treatment of hemorrhage from trauma.     

High-rate Decoupled Water Electrolysis System Integrated with α-MoO3 as a Redox Mediator with Fast Anhydrous Proton Kinetics

Hydrogen is a promising alternative to fossil fuels that can reduce greenhouse gas emissions. Decoupled water electrolysis system using a reversible proton storage redox mediator, where the oxygen evolution reaction and hydrogen evolution reaction are separated in time and space, is an effective approach to producing hydrogen gas with high purity, high flexibility, and low cost. To realize fast hydrogen production in such a system, a redox mediator capable of releasing protons rapidly is required. Herein, α-MoO₃, with an ultrafast proton transfer property that can be explained by a dense hydrogen bond network in the lattice oxygen arrays of HxMoO₃, is examined as a high-rate redox mediator for fast hydrogen production in acidic electrolytes. The α-MoO₃ redox mediator shows both a large capacity of 204 mAh g⁻¹ and fast hydrogen production at a current rate of 10 A cm⁻²(≈153 A g⁻¹), outperforming most of the previously reported solid-state redox mediators.     

Self-identification algorithm for zeolite-based thermal capacity gas sensor

Microsystem Technologies - We demonstrate a new operation mode of thermal gas sensor based on thermal capacity extraction with identification algorithm. The system is a silicon microstructure...     

In vivo anti-influenza virus activity of Kampo (Japanese herbal) medicine "sho-seiryu-to"--stimulation of mucosal immune system and effect on allergic pulmonary inflammation model mice

When BALB/c mice were treated with a Kampo (Japanese herbal) medicine "Sho-seiryu-to (SST)" (1 g/kg, 10 times) orally from 7 days before to 5 days after the infection and infected with mouse-adapted influenza virus A/PR/8/34 by nasal-site restricted infection, SST caused increment of the influenza virus hemagglutinin-specific IgA antibody secreting cells in nasal lymphocyte but not in Peyer's patch lymphocyte at 6 days after infection in comparison with water-treated mice. Oral administration of SST also augmented IL-2 receptor beta chain+ (activated) T-cell in Peyer's patch lymphocyte, but not in the nasal lymphocyte. We previously reported that SST showed potent anti-influenza virus activity through augmentation of the antiviral IgA antibody titer in the nasal and broncho-alveolar cavities of the mice (T. Nagai and H. Yamada, 1994, Int. J. Immunopharmacol. 16, 605-613). These results suggest that oral administration of SST shows anti-influenza virus activity in the nasal cavity by activation of T-cell in Peyer's patch lymphocyte and stimulation of production of anti-influenza virus IgA antibody in nasal lymphocyte. When ovalbumin-sensitized allergic pulmonary inflammation model mice were administered orally with SST (1 g/kg) from 8 days before (11 times) or from 2 h after (4 times) to 4 days after the infection and infected with mouse-adapted influenza virus A/PR/8/34, replications of the virus in the both nasal and broncho-alveolar cavities or only nasal cavity were significantly inhibited at 5 days after infection in comparison with water-treated control by augmenting antiviral IgA antibody, respectively. These results suggest that SST is useful for both prophylaxis and treatment of influenza virus infection on patients with allergic pulmonary inflammation, such as bronchial asthma.     

Carbon felt-based bioelectrocatalytic flow-through detectors: Highly sensitive amperometric determination of H2O2 based on a direct electrochemistry of covalently modified horseradish peroxidase using cyanuric chloride as a linking agent

Horseradish peroxidase (HRP) was chemically modified using cyanuric chloride (CC) as a linking agent onto a carbon felt (CF), which is a microelectrode ensemble of micro carbon fiber (>7 μm, diameter) with a random three-dimensional structure. The resulting HRP-modified CF (HRP-ccCF) exhibited well-defined redox waves based on the HRP heme Fe^III/Fe^II redox couple at −0.23 V vs. Ag/AgCl (at pH 7.0), while the HRP-adsorbed CF (HRP-CF) showed no apparent redox couple in the same potential range, indicating that the chemical modification of HRP via CC facilitated the direct electron transfer (DET) between HRP and CF. The apparent heterogeneous electron transfer rate constant k_s was estimated to be 35 s⁻¹. Cyclic voltammetry and electrochemical impedance spectroscopy revealed that the interfacial properties (i.e., structure, morphology of enzyme-layer) of covalently modified HRP (HRP-ccCF) and physically adsorbed HRP (HRP-CF) are different, resulting in the difference in the electron transfer properties. The HRP-ccCF was successfully used as a working electrode unit in bioelectrocatalytic flow-through detector for highly sensitive amperometric determination of H₂O₂. Under the optimized conditions (i.e., applied potential, 0 V vs. Ag/AgCl; carrier flow rate, 3.25 ml/min; and carrier pH 7.0), the cathodic peak current of H₂O₂ linearly increased up to 3 μM (sensitivity, 1.94 μA/μM; the detection limit, 0.08 μM [S/N = 3]) with sample through-put of ca. 90 samples/h.     

Information gathering and searching approaches on the Web

The information accessible through the Internet is increasing explosively as the Web is getting more and more widespread. In this situation, the Web is indispensable information resource for both of information gathering and information searching. Though traditional information retrieval techniques have been applied to information gathering and searching in the Web, they are insufficient for this new form of information source. Fortunately some Al techniques can be straightforwardly applicable to such tasks in the Web, and many researchers are trying this approach. In this paper, we attempt to describe the current state of information gathering and searching technologies in the Web, and the application of AI techniques in the fields. Then we point out limitations of these traditional and AI approaches and introduce two aapproaches: navigation planning and a Mondou search engine for overcoming them. The navigation planning system tries to collect systematic knowledge, rather than Web pages, which are only pieces of knowledge. The Mondou search engine copes with the problems of the query expansion/modification based on the techniques of text/web mining and information visualization. Seiji Yamada, Dr. Eng.: He received the B.S., M.S. and Ph.S. degrees in control engineering and artificial intelligence from Osaka University, Osaka, Japan, in 1984, 1986 and 1989, respectively. From 1989 to 1991, he served as a Research Associate in the Department of Control Engineering at Osaka University. From 1991 to 1996, he served as a Lecturer in the Institute of Scientific and Industrial Research at Osaka University. In 1996, he joined the Department of Computational Intelligence and Systems Science at Tokyo Institute of Technology, Yokohama, Japan, as an Associate Professor. His research interests include artificial intelligence, planning, machine learning for a robotics, intelligent information retrieval in the WWW, human computer interaction, He is a member of AAAI, IEEE, JSAI, RSJ and IEICE. Hiroyuki Kawano, Dr.Eng.: He is an Associate Professor at the Department of Systems Science, Graduate School of Informatics, Kyoto University, Japan. He obtained his B.Eng. and M.Eng. degrees in Applied Mathematics and Physics, and his Dr.Eng. degree in Applied Systems Science from Kyoto University. His research interests are in advanced database technologies, such as data mining, data warehousing, knowledge discovery and web search engine (Mondou). He has served on the program committees of several conferences in the areas of Data Base Systems, and technical committes of advanced information systems.     

Isolation of penicillin-resistant Streptococcus pneumoniae in Saga Medical School Hospital

A recent nationwide increase in beta-lactams-resistant Streptococcus pneumoniae has attracted a great deal of attention. We studied the drug sensitivity of S. pneumoniae isolated from various clinical specimens in Saga Medical School Hospital between April 1988 and December 1991. To determine the drug sensitivity of the strains, we used a micro-dilution method and determined the MIC. Drug resistance was evaluated using MIC of ampicillin (ABPC) as a reference MIC, and the results were roughly classified into the following three groups: sensitive (< or = 0.1 microgram/ml), moderately resistant (0.2-3.13 micrograms/ml) and highly resistant (> or = 6.25 micrograms/ml). The isolation frequency was calculated on the basis of one strain from one patient. No strain of S. pneumoniae with high resistance against ABPC was found in 1988 (94 strains of S. pneumoniae were isolated) and 1990 (115 strains isolated), but one such strain (0.8%) was found among 129 strains isolated in 1989, and 2 such strains (2.4%) among 84 strains isolated in 1991. Moderately resistant strains were isolated at the frequencies of 12.8%, 15.5%, 22.6%, and 21.4% respectively, in 1988, 1989, 1990, and 1991. A sum of the frequencies of "moderately resistant" and "highly resistant" (2.4%) strains was 23.8% in 1991. The frequency of resistant strains is increasing and the intensity of resistance is also being elevated.     

Localization of vitamin A in the small intestine of mouse. An electron microscope radioautographic study

Localization of vitamin A in the small intestine of mice was studied with electron microscope radioautography after administration of tritiated vitamin A. The label was concentrated over lipid droplets in cells distributed in the lamina propria and the submucous layer. The cells were similar both to fibroblasts and to fat-storing cells in their morphological features. The name "Vitamin A-Storing Cell" is proposed for these labeled cells, including the fat-storing cell in the liver.     

Seamless handover supported by parallel polling and dynamic multicast group in connected WLAN micro-cells system

WLAN (Wireless Local Area Network) has been seen to be one of the promising access technologies that adapts to 4G cellular network systems in providing very high speed connection with QoS guarantee through the polling function. However, when the handover happens, the contention-based medium access mechanism which is mainly used in WLAN is invoked and introduces unbounded transmission delay due to idle time periods and retransmission because of collision during the handover. If this technique is expanded to use in a microcellular network such as connected WLAN micro-cells, contention-based mechanism, therefore, should not be used to handle the MT’s handover, especially for vehicular users who change access point every few seconds. To overcome these difficulties in handover, we introduce parallel polling scheme in dynamic LMC (Logical Macro Cell) which can reduce delays much and remove packet loss rate. LMC is a virtual single macro cell which is built on a multicast group of adjacent micro-cells. In the same LMC, polling signals are sent from every BS (base station) to give MT (mobile terminal) permission to access one of these BSs. Instead of wasting much time to contend for resources of a new BS during handover, the MT answers the polling as an acknowledgment to connect to that new BS. The polling response is controlled to multicast to all BSs of the same LMC via the core network to synchronize for the next polling cycle. LMC is controlled to dynamically change when the MT comes in a new BS to make polling signals be continuous in a new LMC. Through analytical and simulation results, we show that the parallel polling scheme can achieve no handover latency, no packet loss and maintain mobile users’ throughput stably in the high traffic load condition though it causes overhead on the neighboring cells in both of wired and wireless sections. At speeds of up to70 m/s, the MT can still maintain its stable connection. OMNeT++ simulator with INET project is used to evaluate our proposal.