Modeling polypharmacy effects with heterogeneous signed graph convolutional networks

Applied Intelligence - Pharmaceutical drug combinations can effectively treat various medical conditions. However, some combinations can cause serious adverse drug reactions (ADR). Therefore,...     

多媒体教学中的问题与对策

随着计算机技术及多媒体技术的发展,多媒体在教学中的应用越来越广泛,多媒体有着传统教学媒体不具备的独特优势,但在实际教学中也有不足之处,在教学中必须根据实际情况灵活运用多媒体才能取得理想的教学效果。     

Symmetry-induced modal characteristics in uniform waveguides or resonators with ferrite rods

A technique of symmetry analysis for modal characteristics in uniform waveguides or resonators with ferrite rods is presented here. Symmetry analysis can provide basic information concerning modal characteristics. After summarizing the basic principles of symmetry analysis, some points concerning symmetry operations are discussed. Then the process of symmetry analysis is applied to structures, i.e. uniform wave guides withC _n symmetry or symmetry and resonators withD _nh symmetry in which exist longitudinally magnetized ferrite rods. Finally, results of the symmetry analysis are given in four tables.     

屏蔽线缆的接地仿真研究

在外界电磁波的干扰下,线缆会在车辆内部产生很强的耦合电流和电压,严重影响车辆正常工作,一般需要采用屏蔽线缆来减少干扰. 屏蔽线缆抑制电磁干扰的能力,不仅和线缆本身的屏蔽层有关,还须选择正确的接地方式. 着重对线缆的多种接地方式进行仿真研究,分析不同接地位置和数目对线缆抗干扰性能的影响,为实际车辆线缆防护提供参考.     

Na+掺杂对LiNi1/3Co1/3Mn1/3O2结构和电化学性质的影响

采用高温固相法成功制备了不同Na+掺杂浓度的Li_1-xNa_xNi_1/3Co_1/3Mn_1/3O₂锂离子电池正极材料,探究了Na元素掺杂对层状氧化物正极材料结构以及电化学性能的影响。通过X射线粉末衍射仪和扫描电子显微镜表征了材料的结构和形貌,结果表明,当x≤0.3时,样品不会出现其它杂相;当x＞0.3时,样品中会出现NaNi_1/3Co_1/3Mn_1/3O₂的杂相。同时随着掺杂浓度的增加,样品的阳离子混排度逐渐增加。电化学性能结果表明,少量Na+的掺入可以提高LiNi_1/3Co_1/3Mn_1/3O₂在0.2C,0.5C下的放电比容量并增强其循环稳定性,但会损坏材料的倍率性能。     

盐雾环境下瓷及复合绝缘子积污特性模拟研究

盐雾环境下的污秽物具有较高的可溶盐含量,可造成绝缘子绝缘性能下降,进而危及电力系统的安全运行.以XWP2-160型瓷双伞绝缘子和FXBW-110/120-2型复合绝缘子为研究对象,基于场致荷电机理,利用多物理场耦合软件COMSOL对其积污特性进行数值模拟,探索了盐密ESDD的计算方法,并验证了其合理性.利用该方法研究了盐雾环境下风速、雾滴粒径、电压类型对瓷及复合绝缘子积污特性的影响,分析了污秽沿绝缘子伞裙的分布规律.结果表明:复合绝缘子的积污量大于同条件下瓷双伞绝缘子积污量,盐雾环境频发地区可优先考虑瓷双伞绝缘子;直流电压下,瓷及复合绝缘子的积污量增长趋势均与风速、粒径呈正相关;复合绝缘子积污量沿伞裙近似呈U型分布,瓷双伞绝缘子积污量沿伞裙近似呈M型分布,且风速越大分布趋势越明显.     

Design,Synthesis, and Biological Evaluation of Novel 6H-Benzo[c]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors

Urolithins (hydroxylated 6H-benzo[c]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series of alkoxylated 6H-benzo[c]chromen-6-one derivatives were designed and synthesized. Furthermore, their biological activities were evaluated as potential PDE2 inhibitors, and the alkoxylated 6H-benzo[c]chromen-6-one derivative 1f was found to have the optimal inhibitory potential (IC₅₀: 3.67 ± 0.47 μM). It also exhibited comparable activity in comparison to that of BAY 60-7550 in vitro cell level studies.     

Hygroresponsive Torsional Yarns and Actuators Based on Cascade Amplification of the Deformation

Fiber-based hygroresponsive torsional actuators provide desirable merits, such as light weight and shapeability, for developing smart systems to harvest energy from moisture which is a ubiquitous natural resource. A key challenge in this development is to realize moisture-triggered actuation combining large actuation and rapid responses. Here, a multiscale design strategy is explored to create high-performance hygroresponsive torsional actuators consisting of chitosan and multiwalled carbon nanotubes (MWCNTs). The superior actuation performance arises from the synergism of contributing factors at different scales, including 1) MWNCTs accelerate the water transport in primary twisted fibers (PTFs), fostering the rotation of PTFs upon moisture stimuli; 2) in situ-formed hierarchically-assembled twists realize cascade amplification of moisture-triggered actuation. Specifically, PTFs are self-twisted to generate secondary helical yarns, that are subsequently over-twisted to yield tertiary coiled yarn. The resultant yarn actuator can reach a maximum rotation speed of 11 400 rpm in 5 s, output gravitational potential energy of 2.4 J kg⁻¹ and gravitational potential power of 0.053 W kg⁻¹ during contraction. This work represents the first design of fiber-based actuators by virtue of moisture-triggered in situ formation of yarns. The established principles of multiscale design will enable high-performance fiber-based hygroresponsive actuators toward advanced intelligent textile and soft robotics.     

基于布尔代数的海底管道风险评价方法研究与应用

根据目标管道的实际情况,将目标海底管道分为平台立管段、海域管段、人工岛登陆段3段,确定了第三方损坏、腐蚀、制造与施工缺陷、误操作4个一级风险因素,细化二级风险因素,建立了包含23个指标的风险评价指标体系.对指数和相加的方法进行改进,把各项风险分值进行归一化处理,量化至0～1之间,基于布尔代数,运用故障树的逻辑或原理,计算失效概率和泄漏影响系数,得到改进后的海底管道半定量风险评价模型,解决了传统模型中的风险值相加导致的风险遮蔽问题.     

La3+ 掺杂对 CeO2 红外发射性能的影响研究

随着飞行器飞行速度和发动机燃烧室温度的提高, 金属类隐身涂层材料已无法满足环境使用要求。 CeO2 具有较高熔点、 抗氧化、 较低红外发射率等特点, 被认为是红外隐身应用的候选材料, 但其发射率仍无法满足 高温红外隐身需求。 本文通过固相反应法对 CeO2 进行 La3+ 掺杂改性, 研究掺杂量对 CeO2 粉体红外发射性能的 影响规律。 结果表明, 随着掺杂量从 10 mol% 增加到 30 mol%, 粉体在 3~6 μm 波段的发射率不断降低, 其中 Ce0.7La0.3O2 的红外发射率仅为 0.1。