全文获取类型
收费全文 | 259761篇 |
免费 | 17882篇 |
国内免费 | 7738篇 |
专业分类
电工技术 | 10875篇 |
技术理论 | 11篇 |
综合类 | 10930篇 |
化学工业 | 44808篇 |
金属工艺 | 12456篇 |
机械仪表 | 16062篇 |
建筑科学 | 14265篇 |
矿业工程 | 4433篇 |
能源动力 | 8732篇 |
轻工业 | 18378篇 |
水利工程 | 3390篇 |
石油天然气 | 9094篇 |
武器工业 | 1205篇 |
无线电 | 35580篇 |
一般工业技术 | 39409篇 |
冶金工业 | 18462篇 |
原子能技术 | 3040篇 |
自动化技术 | 34251篇 |
出版年
2024年 | 572篇 |
2023年 | 3112篇 |
2022年 | 5287篇 |
2021年 | 8437篇 |
2020年 | 6262篇 |
2019年 | 5806篇 |
2018年 | 6914篇 |
2017年 | 7270篇 |
2016年 | 7506篇 |
2015年 | 8249篇 |
2014年 | 11168篇 |
2013年 | 15782篇 |
2012年 | 15677篇 |
2011年 | 17997篇 |
2010年 | 15158篇 |
2009年 | 14974篇 |
2008年 | 14510篇 |
2007年 | 13346篇 |
2006年 | 12754篇 |
2005年 | 11132篇 |
2004年 | 8756篇 |
2003年 | 8174篇 |
2002年 | 8113篇 |
2001年 | 6902篇 |
2000年 | 6178篇 |
1999年 | 5941篇 |
1998年 | 7320篇 |
1997年 | 5242篇 |
1996年 | 4708篇 |
1995年 | 3770篇 |
1994年 | 3070篇 |
1993年 | 2546篇 |
1992年 | 1880篇 |
1991年 | 1642篇 |
1990年 | 1377篇 |
1989年 | 1239篇 |
1988年 | 1006篇 |
1987年 | 799篇 |
1986年 | 656篇 |
1985年 | 580篇 |
1984年 | 475篇 |
1983年 | 370篇 |
1982年 | 319篇 |
1981年 | 282篇 |
1980年 | 279篇 |
1979年 | 204篇 |
1978年 | 180篇 |
1977年 | 238篇 |
1976年 | 325篇 |
1975年 | 139篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
31.
Silicon - Quadruple gate FinFET is a promising candidate among other multi-gate MOS devices due to it’s better scalability and higher short channel effect suppression capability in advanced... 相似文献
32.
Bokyung Kim Young Ho Ko Massimiliano Runfola Simona Rapposelli Gabriella Ortore Grazia Chiellini Jin Hae Kim 《International journal of molecular sciences》2021,22(7)
Thyromimetics, whose physicochemical characteristics are analog to thyroid hormones (THs) and their derivatives, are promising candidates as novel therapeutics for neurodegenerative and metabolic pathologies. In particular, sobetirome (GC-1), one of the initial halogen-free thyromimetics, and newly synthesized IS25 and TG68, with optimized ADME-Tox profile, have recently attracted attention owing to their superior therapeutic benefits, selectivity, and enhanced permeability. Here, we further explored the functional capabilities of these thyromimetics to inhibit transthyretin (TTR) amyloidosis. TTR is a homotetrameric transporter protein for THs, yet it is also responsible for severe amyloid fibril formation, which is facilitated by tetramer dissociation into non-native monomers. By combining nuclear magnetic resonance (NMR) spectroscopy, computational simulation, and biochemical assays, we found that GC-1 and newly designed diphenyl-methane-based thyromimetics, namely IS25 and TG68, are TTR stabilizers and efficient suppressors of TTR aggregation. Based on these observations, we propose the novel potential of thyromimetics as a multi-functional therapeutic molecule for TTR-related pathologies, including neurodegenerative diseases. 相似文献
33.
Fangjun Zhu You Shi Guorong Hu Zhongdong Peng Yanbing Cao Qian Sun Zhichen Xue Yinjia Zhang Ke Du 《Ceramics International》2021,47(3):3070-3078
Titanium and boron are simultaneously introduced into LiNi0.8Co0.1Mn0.1O2 to improve the structural stability and electrochemical performance of the material. X-ray diffraction studies reveal that Ti4+ ion replaces Li+ ion and reduces the cation mixing; B3+ ion enters the tetrahedron of the transition metal layers and enlarges the distance of the [LiO6] layers. The co-doped sample has spherical secondary particles with elongated and enlarged primary particles, in which Ti and B elements distribute uniformly. Electrochemical studies reveal the co-doped sample has improved rate performance (183.1 mAh·g-1 at 1 C and 155.5 mAh·g-1 at 10 C) and cycle stability (capacity retention of 94.7% after 100 cycles at 1 C). EIS and CV disclose that Ti and B co-doping reduces charge transfer impedance and suppresses phase change of LiNi0.8Co0.1Mn0.1O2. 相似文献
34.
Food Science and Biotechnology - MV was reported to have beneficial effects in ameliorating insulin resistance in db/db mice, but the intrinsic mechanisms for glucose homeostasis are unclear. This... 相似文献
36.
Sangmin Lee Biao Che Meiling Tai Wanzhao Li Shin-Hyun Kim 《Advanced functional materials》2021,31(42):2105477
Hydrogel shells that compartmentalize the water core from the aqueous surrounding provide molecular selectivity on size and charge in transmembrane transport. It is highly demanding to produce thin hydrogel shells to minimize diffusion length and maximize core volume. Here, internal osmosis in water-in-oil-in-water-in-oil (W/O/W/O) triple-emulsion droplets is used to produce thin hydrogel shells enclosing a large water core. The triple-emulsion droplets are prepared to have an ultrathin middle oil layer using a capillary microfluidic device. The innermost water droplet has a higher osmolarity than the outer water layer containing photopolymerizable hydrogel precursors, which pumps water from the outer layer to the core through the ultrathin oil layer by the osmosis. Therefore, the outer layer gets thinner and hydrogel precursors are enriched while the size of the triple-emulsion droplets remains unchanged. Through photopolymerization of precursors and phase transfer from oil to water, hydrogel shells enclosing water core are produced in the water environment; the oil layer is ruptured for molecular exchange through the shells. The thickness and composition of the hydrogel shells are precisely controllable by the osmotic conditions. The shells show a high permeation rate due to the thinness as well as controlled cut-off threshold of permeation for neutral and charged molecules. 相似文献
37.
Ping Xiao Jue Wang Lei Fang Zitong Zhao Xiangshi Sun Xiaochen Liu Haiqiang Cao Pengcheng Zhang Dangge Wang Yaping Li 《Advanced functional materials》2021,31(36):2104068
Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. 相似文献
38.
Jinshuang Wang Luyao Chen Mengdi Chen Yuyang Wu Yinghui Wang Yongsheng Yu Junbin Sun Bing Liu Qiangshan Jing 《Ceramics International》2021,47(16):22965-22975
In this study, the destabilization resistance of Sc2O3 and CeO2 co-stabilized ZrO2 (SCZ) ceramics was tested in Na2SO4 + V2O5 molten salts at 750°C–1100 °C. The phase structure and microstructure evolution of the samples during the hot corrosion testing were analyzed with X-ray diffraction (XRD), Raman spectra, scanning electron microscopy (SEM), energy dispersive X-ray spectrum (EDS), and X-ray photoelectron spectroscopy (XPS). Results showed that the destabilization of SCZ ceramics at 750 °C was the result of the chemical reaction with V2O5 to produce m-ZrO2 and CeVO4, and little ScVO4 was detected in the Sc2O3-rich SCZ ceramics. The primary corrosion products at 900 °C and 1100 °C were CeO2 and m-ZrO2 due to the mineralization effect. The Sc2O3-rich SCZ ceramics exhibited excellent degradation resistance and phase stability owing to the enhanced bond strength and the decreased size misfit between Zr4+ and Sc3+. The destabilization mechanism of SCZ ceramic under hot corrosion was also discussed. 相似文献
39.
Li Qian Chen Yan Sun Shikun Zhu Muyuan Xue Jing Gao Zihan Zhao Jinfeng Tang Yihe 《Water Resources Management》2022,36(12):4799-4817
Water Resources Management - Increasing water consumption in agriculture due to global climate change has posed considerable challenges to food security, thus improving the efficiency of water... 相似文献
40.
Cho-Yi Chen Masaoki Kawasumi Tien-Yun Lan Chi-Lam Poon Yi-Sian Lin Pin-Jou Wu Yao-Chung Chen Bing-Hong Chen Cheng-Hsien Wu Jeng-Fan Lo Rueyhung Roc Weng Yi-Chen Sun Kai-Feng Hung 《International journal of molecular sciences》2021,22(1)
Endoplasmic reticulum (ER) stress response is an adaptive program to cope with cellular stress that disturbs the function and homeostasis of ER, which commonly occurs during cancer progression to late stage. Late-stage cancers, mostly requiring chemotherapy, often develop treatment resistance. Chemoresistance has been linked to ER stress response; however, most of the evidence has come from studies that correlate the expression of stress markers with poor prognosis or demonstrate proapoptosis by the knockdown of stress-responsive genes. Since ER stress in cancers usually persists and is essentially not induced by genetic manipulations, we used low doses of ER stress inducers at levels that allowed cell adaptation to occur in order to investigate the effect of stress response on chemoresistance. We found that prolonged tolerable ER stress promotes mesenchymal–epithelial transition, slows cell-cycle progression, and delays the S-phase exit. Consequently, cisplatin-induced apoptosis was significantly decreased in stress-adapted cells, implying their acquisition of cisplatin resistance. Molecularly, we found that proliferating cell nuclear antigen (PCNA) ubiquitination and the expression of polymerase η, the main polymerase responsible for translesion synthesis across cisplatin-DNA damage, were up-regulated in ER stress-adaptive cells, and their enhanced cisplatin resistance was abrogated by the knockout of polymerase η. We also found that a fraction of p53 in stress-adapted cells was translocated to the nucleus, and that these cells exhibited a significant decline in the level of cisplatin-DNA damage. Consistently, we showed that the nuclear p53 coincided with strong positivity of glucose-related protein 78 (GRP78) on immunostaining of clinical biopsies, and the cisplatin-based chemotherapy was less effective for patients with high levels of ER stress. Taken together, this study uncovers that adaptation to ER stress enhances DNA repair and damage tolerance, with which stressed cells gain resistance to chemotherapeutics. 相似文献