Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege

Interleukin-27 is constitutively secreted by microglia in the retina or brain, and upregulation of IL-27 during neuroinflammation suppresses encephalomyelitis and autoimmune uveitis. However, while IL-35 is structurally and functionally similar to IL-27, the intrinsic roles of IL-35 in CNS tissues are unknown. Thus, we generated IL-35/YFP-knock-in reporter mice (p35-KI) and demonstrated that photoreceptor neurons constitutively secrete IL-35, which might protect the retina from persistent low-grade inflammation that can impair photoreceptor functions. Furthermore, the p35-KI mouse, which is hemizygous at the il12a locus, develops more severe uveitis because of reduced IL-35 expression. Interestingly, onset and exacerbation of uveitis in p35-KI mice caused by extravasation of proinflammatory Th1/Th17 lymphocytes into the retina were preceded by a dramatic decrease of IL-35, attributable to massive death of photoreceptor cells. Thus, while inflammation-induced death of photoreceptors and loss of protective effects of IL-35 exacerbated uveitis, our data also suggest that constitutive production of IL-35 in the retina might have housekeeping functions that promote sterilization immunity in the neuroretina and maintain ocular immune privilege.     

Experimental investigation on the CO2 laser cutting of soda-lime glass

Journal of Mechanical Science and Technology - This study reports on complete glass cutting using a single CO2 laser beam with a low power of several tens of watts. In this study, the morphological...     

光栅衍射缝间干涉因子次极大强度对称性的菲涅耳半波带法证明

本文用菲涅耳半波带法推导出了一个非常有用的次极大位置公式,将该位置公式和振幅矢量法求出的次极大位置结合起来,方便地求出了缝间干涉因子的次极大的强度,证明了缝向干涉因子的次极大强度具有对称性。避免了对振幅矢量法求次极大位置这个方程的直接求解,因为用该方法求出的次极大强度与理论值完全符合,说明菲涅耳半波带法不但可以用来分析单缝衍射,同时还完全能够用来分析光栅衍射。     

Preparation of Mo2C by MPCVD and Its Photocatalytic Properties

Mo2C was prepared by microwave plasma chemical vapor deposition(MPCVD)technique with the power of 800 W and pressure of 18 kPa. Compared with traditional prepar...     

Effects of Tearing Conditions on the Crack Propagation in a Monolayer Graphene Sheet

The path of crack propagation in a graphene sheet is significant for graphene patterning via the tearing approach. In this study, we evaluate the fracture properties of pre-cracked graphene during the tearing process, with consideration of the effects of the aspect ratio, loading speed, loading direction, and ambient temperatures on the crack propagation in the monolayer sheet. Some remarkable conclusions are drawn based on the molecular dynamic simulation results, i.e., a higher loading speed may result in a complicated path of crack propagation, and the propagation of an armchair crack may be accompanied by sp carbon links at high temperatures. The reason for this is that the stronger thermal vibration reduces the load stress difference near the crack tip and, therefore, the crack tip can pass through the sp link. A crack propagates more easily along the zigzag direction than along the armchair direction. The out-of-plane tearing is more suitable than the in-plane tearing for graphene patterning. The path of crack propagation can be adjusted by changing the loading direction, e.g., a rectangular graphene ribbon can be produced by oblique tearing. This new understanding will benefit the application of graphene patterning via the tearing approach.     

关于原酒贮存条件的试验及讨论

对原酒贮存过程,不同的贮存容器和温度对原酒贮存效果进行了研究。结果表明,高温贮酒比常温贮酒在较短时间内效果好;高温贮酒的酸酯转换速度比常温贮存要快,与贮存近两年左右的酒十分相似;高温贮酒可缩短原酒贮存期,而且在室温下放置,其理化指标没有出现可逆现象,口感优于或接近于贮存近2年的原酒;高温贮存30d与60d相比,无论是理化指标和口感都没有明显差异。     

A deep-learning-based prediction method of the estimated ultimate recovery(EUR)of shale gas wells

The estimated ultimate recovery(EUR)of shale gas wells is influenced by many factors,and the accurate prediction still faces certain challenges.As an artificial...     

株溪口电站土石围堰控制性灌浆施工工艺

在水利水电工程中,围堰的防渗效果对工程主体的施工进度和经济效益影响相当大．控制性灌浆是围堰堵漏防渗的重要方法之一。文章就株溪口水电站一期围堰控制性灌浆的施工工艺进行分析,其施工方法可供相同施工条件的围堰进行参考。     

Determination of the embedded electronic states at nanoscale interface via surface-sensitive photoemission spectroscopy

The fabrication of small-scale electronics usually involves the integration of different functional materials. The electronic states at the nanoscale interface ...