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951.
Experimental evidence that indicates a positive effect of rotational transform on thermal transport has been shown for electron cyclotron heated plasmas on large helical device (LHD). Although this positive dependence was suggested by earlier scaling studies on energy confinement time, there was a concern that rotational transform is strongly correlated with another major non-dimensional parameter, that is, aspect ratio, in stellarator–heliotron systems. A careful experiment to exclude correlation between these two non-dimensional parameters was carried out on LHD by means of combining helical coil pitch control and limiter insertion. Plasmas with similar aspect ratio but different rotational transform have been compared in terms of global energy confinement time and local heat diffusivity. Energy confinement time increases with the rotational transform. Also the comparison of plasmas dimensionally similar in terms of normalized gyro-radius, collisionality, normalized pressure and aspect ratio has indicated that thermal transport improves with rotational transform. Since the plasmas studied here are dominated by turbulent transport rather than neoclassical transport, the identified feature, common to toroidal plasmas with tokamak, will stimulate the challenge to resolve the origin of the favorable effect of poloidal field and the compatibility with drift turbulence theory.  相似文献   
952.
953.
Sound field analysis is complicated and computationally intensive. In this paper, a two-dimensional sound field solver based on the Digital Huygens’ Model (DHM) is designed and implemented by a Field Programmable Gate Array (FPGA). In this sound field solver, the original DHM and its boundary condition are extended to reduce operations and hardware resource consumption. The computation is completed locally, and external memory access is avoided. In a two-dimensional space with both length and width being 1.28 m, when boundaries are rigid walls, the FPGA-based analysis system enhances performance from 44 to 217 times, and from 37 to 179 times against the software simulations based on the original DHM and Standard Leapfrog Finite-difference Time-domain (SLF-FDTD), respectively. Compared with the General-purpose Graphic Processing Unit (GPGPU) Tesla C1060, it speeds up by 1223 times in computation and by 114 times in overall performance in the case of time steps being 20,000. When the node scales are different and the calculated time steps are 32,000, the FPGA-based sound field solver achieves about 1795 and 1190 times faster in computation, 218 and 179 times enhancement in final performance over the software simulations based on the original DHM and SLF-FDTD, respectively. Furthermore, the proposed system provides high data throughput, and is easily applied in real-time applications.  相似文献   
954.
955.
Sex pheromone investigations of the domesticated silkmoth, Bombyx mori (Lepidoptera: Bombycidae), helped elucidate the molecular and physiological fundamentals of chemical communication in moths, yet little is known about pheromone evolution in bombycid species. Therefore, we reexamined the sex pheromone communication in the wild silkmoth, Bombyx mandarina, which is considered ancestral to B. mori. Our investigations revealed that (a) B. mandarina females produce (E,Z)-10,12-hexadecadienol (bombykol), but not (E,Z)-10,12-hexadecadienal (bombykal) or (E,Z)-10,12-hexadecadienyl acetate (bombykyl acetate), which are pheromone components in other bombycid moths; (b) antennae of male B. mandarina respond strongly to bombykol as well as to bombykal and bombykyl acetate; and (c) bombykal and bombykyl acetate strongly inhibit attraction of B. mandarina males to bombykol in the field. The present study clarifies the evolution of pheromone communication in bombycid moths.  相似文献   
956.
Alignment methods of nematic liquid crystals (LCs) by surface photoreactions on substrate surfaces were initially proposed around 1990, and the photoalignment technology of nematic LCs has recently been integrated into the LC device fabrication industry due to its profitable features. Accumulated efforts in this field have revealed that applications of photoalignment processes are not limited to conventional nematic LCs but that a variety of functional materials can also be manipulated according to this principle. Target materials have now been extended to thermotropic smectic LCs, discotic LCs, LC polymers, block copolymers, gel networks, conjugated polymers, and organic semiconductors and lyotropic systems including chromonic LCs and inorganic–organic mesostructured hybrids. Through these photochemical approaches, many types of photopatterning for both topographical and orientational modulations have become feasible. This article reviews photoalignment processes applied to a wide range of materials, surveying relatively recent work. Some important related alignment and patterning processes are also introduced to clarify the significance of these photoalignment techniques.  相似文献   
957.
Enamel matrix derivative (EMD) has been found to induce reactive dentin formation; however the molecular mechanisms involved are unclear. The effect of EMD (5–50 μg/mL) on primary human pulp cells were compared to untreated cells and cells incubated with 10−8 M dexamethasone (DEX) for 1, 2, 3, 7, and 14 days in culture. Expression analysis using Affymetrix microchips demonstrated that 10 μg/mL EMD regulated several hundred genes and stimulated the gene expression of proteins involved in mesenchymal proliferation and differentiation. Both EMD and DEX enhanced the expression of amelogenin (amel), and the dentinogenic markers dentin sialophosphoprotein (DSSP) and dentin matrix acidic phosphoprotein 1 (DMP1), as well as the osteogenic markers osteocalcin (OC, BGLAP) and collagen type 1 (COL1A1). Whereas, only EMD had effect on alkaline phosphatase (ALP) mRNA expression, the stimulatory effect were verified by enhanced secretion of OC and COL1A from EMD treated cells, and increased ALP activity in cell culture medium after EMD treatment. Increased levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant proteins (MCP-1) in the cell culture medium were also found. Consequently, the suggested effect of EMD is to promote differentiation of pulp cells and increases the potential for pulpal mineralization to favor reactive dentine formation.  相似文献   
958.
The grafting of vinyl polymers onto the surface of polymethylsiloxane-coated titanium dioxide modified with alcoholic hydroxyl groups (Ti/Si–R–OH) were investigated. The introduction of azo and trichloroacetyl groups onto the surface of Ti/Si–R–OH was achieved by the reaction of the surface alcoholic hydroxyl groups with 4,4′-azobis(4-cyanopentanoic acid) and trichloroacetyl isocyanate, respectively. The radical polymerizations of vinyl monomers were successfully initiated by the azo groups introduced onto the surface and by the system consisting of Mo(CO)6 and Ti/Si–R–COCCl3. During the polymerization, the corresponding polymers were effectively grafted onto the titanium dioxide surface through propagation from surface radicals formed by the decomposition of azo groups and by the reaction of Mo(CO)6 with trichloroacetyl groups on the surface. The percentage of grafting and grafting efficiency in the graft polymerization initiated by the system consisting of Ti/Si–R–COCCl3 and Mo(CO)6 were much larger than those initiated by azo groups. The polymer-grafted titanium dioxide was found to produce a stable colloidal dispersion in good solvents for the grafted polymer. The dispersibility of poly(N,N-diethylacrylamide)-grafted titanium dioxide in water was controlled by temperature. In addition, the wettability of the surface of titanium dioxide to water was readily controlled by grafting of hydrophilic or hydrophobic polymers.  相似文献   
959.
The oval squid Sepioteuthis lessoniana is one of the most economically important squid species in Japan; however, its population structure is poorly understood due to the lack of hypervariable markers. Such information is critical for managing sustainable fisheries, as well as for ensuring the existence of wild S. lessoniana stocks. Eleven candidate microsatellite loci were isolated from a small insert genomic DNA library. Polymorphisms in these 11 loci were screened in 24 wild individuals. The number of alleles per locus was found to range from 5 to 19 alleles, and the observed heterozygosity ranged from 0.292 to 0.958. No evidence for linkage disequilibrium was detected among all the loci. The genotypic proportions conformed to Hardy-Weinberg equilibrium, except at one locus. In conclusion, these polymorphic microsatellite loci may be used to develop a genetic framework to manage S. lessoniana in the future.  相似文献   
960.
    
In humans, the coronin family is composed of seven proteins containing WD-repeat domains that regulate actin-based cellular processes. Some members of the coronin family are closely associated with cancer cell migration and invasion. The Cancer Genome Atlas (TCGA) analysis revealed that CORO1C, CORO2A, and CORO7 were significantly upregulated in oral squamous cell carcinoma (OSCC) tissues (p < 0.05). Moreover, the high expression of CORO2A was significantly predictive of the 5-year survival rate of patients with OSCC (p = 0.0203). Overexpression of CORO2A was detected in OSCC clinical specimens by immunostaining. siRNA-mediated knockdown of CORO2A suppressed cancer cell migration and invasion abilities. Furthermore, we investigated the involvement of microRNAs (miRNAs) in the molecular mechanism underlying CORO2A overexpression in OSCC cells. TCGA analysis confirmed that tumor-suppressive miR-125b-5p and miR-140-5p were significantly downregulated in OSCC tissues. Notably, these miRNAs bound directly to the 3′-UTR of CORO2A and controlled CORO2A expression in OSCC cells. In summary, we found that aberrant expression of CORO2A facilitates the malignant transformation of OSCC cells, and that downregulation of tumor-suppressive miRNAs is involved in CORO2A overexpression. Elucidation of the interaction between genes and miRNAs will help reveal the molecular pathogenesis of OSCC.  相似文献   
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