Effect of puerarin on the P13K pathway for glucose transportation and insulin signal transduction in adipocytes

To explore the effect of puerarin on insulin receptor (IR), insulin receptor substrate-1 (IRS-1) and protein expression of protein kinase B(PKB) in the P13K pathway of the glucose consumption, transportation and insulin signal transduction in 3T3-L1 adipocytes with insulin resistance. The insulin resistance 3T3-L1 adipocytes model was established by free fatty acid induction. The model cells were managed with puerarin in different concentrations. Glucose consumption was detected with glucose oxidase method, glucose transportation rate was determined by 2-deoxy-3H glucose ingesting method, and the IR, IRS-1 and PKB expression were determined by Western blot. Glucose consumption and transportation were significantly decreased in the model adipocytes, but increased after treated with puerarin (P<0.01). Moreover, the level of tyrosine phosphorylation of IR subunit β was higher in the puerarin treated groups, and that of IRS-1 was higher in the group treated with low dose puerarin than that in the model group. The 3T3-L1 adipocytes of insulin resistance model could be induced by free fatty acid successfully, puerarin could promote the glucose utilization in them to alleviate the insulin resistance, which may be related with the action in advancing the tyrosine phosphorylation of IR and IRS-1.     

Zn掺杂对GdMnO体系的晶体结构影响

系统研究了Gd（1-x）ZnxMnO3（x=0,0.2,0.4,0.6,0.8,1.0）体系的结构。结果表明,实验样品具有正交对称性结构。当Zn掺杂浓度x≤0.4时,随着Zn掺杂浓度的增加,晶格常数b、c减小,而晶格常数a增大,晶胞体积逐渐减小;当掺杂浓度x≥0.6时,Zn掺杂浓度的增加,晶格常数b、c增大,而晶格常数a减小,晶胞体积逐渐增大。计算表明Gd（1-x）ZnxMnO3系列化合物的容忍因子在0.76~0.92范围,可以形成稳定的钙钛矿结构。     

Damage and deterioration mechanism and curing technique of concrete structure in main coal cleaning plants

Concrete structures in main coal cleaning plants have been rebuilt and reinforced in the coal mines of the Shanghai Da-tun Energy Sources Co. Ltd., the first colliery of the Pingdingshan Coal Co. Ltd. and the Sanhejian mine of the Xuzhou Mining Group Co. Ltd. In these projects, the operating environment and reliability of concrete structures in the main plants of the three companies were investigated and the safety of the structures inspected. Qualitative and quantitative analyses were made on the spe-cial natural, technological and mechanical environments around the structures. On the basis of these analyses, we discuss the long-term, combined actions of the harsh natural (corrosive gases, liquids and solids) and mechanical environments on concrete structures and further investigated the damage and deteriorating mechanisms and curing techniques of concrete structures in the main coal cleaning plants. Our study can provide a theoretical basis for ensuring the reliability of concrete structures in main coal cleaning plants.     

一锅法催化合成N-苄基-4-甲基苯胺

以Raney-Ni为催化剂,对甲基硝基苯和苯甲醛为原料一锅法催化合成了N-苄基-4-甲基苯胺.考察了氢压、反应温度、反应时间、催化剂用量及物料配比等对N-苄基-4-甲基苯胺合成的影响,探讨了一锅法催化合成了N-苄基-4-甲基苯胺的反应机理.实验结果表明,以对甲基硝基苯和苯甲醛为原料一锅法催化合成N-苄基-4-甲基苯胺的反应过程是分二步进行的.优化的合成N-苄基-4-甲基苯胺工艺条件为:苯甲醛与对甲基硝基苯的摩尔比为1:1.0～1:1.02;Raney-Ni催化剂用量为5%(以对甲基硝基苯用量计);氢压为1.0 Mpa;反应温度为353 K;反应时间为90 min.在此所选择的条件下,N-苄基-4-甲基苯胺的收率达99.1%～99.7%.     

高压旋喷桩复合地基承载特性的有限元分析

结合工程实际,运用大型有限元分析软件ANSYS分析了不同桩长、不同桩土模量比和不同桩间距情况下高压旋喷桩复合地基的承载特性.结果表明,该地基存在有效桩长,当桩土模量较合适时,该地基能够发挥最大作用;同时运用ANSYS优化功能,得出了最优桩长、最优桩体弹性模量和最优桩间距,为实际工程提供一些参考.     

层状磷酸锆的制备及插层研究

具有层状结构的磷酸锆α-Zr（HPO4）2·H2O通过粉末X-射线衍射（XRD）,振动光谱（红外IR和拉曼光谱Raman）,热分析仪（TG）,透射电子显微镜（TEM）,扫描电子显微镜（SEM）和BET氮气吸附等手段进行了表征.所制备的α-Zr（HPO4）2·H2O的BET表面积为12.29 m^2/g.研究了α-Zr（HPO4）2·H2O的插入行为,与四甲基溴化铵和十六烷基三甲基溴化铵的插入反应表明插入是完全的,层间距分别增加了0.46 nm和1.68 nm,且插入化合物的荧光性质在室温被检测.     

基于CSY型传感器的悬臂力学试验确定材料弹性模量的方法

对在CSY型传感器综合实验仪上拓展悬臂梁力学实验进行了研究,研究了在该实验仪上实现材料弹性模量的测定.通过材料力学的理论推导出悬臂梁弹性模量与其受力和挠度比值的关系,通过应变式传感器的实验确定出悬臂梁受力与其挠度的比值关系,进一步可推导出悬臂梁材料的弹性模量,并验证了该方法的可行性及有效性.该方法集合了电阻应变效应、全桥差动电路等传感器电测技术以及材料弹性力学、悬臂梁结构力学的基础知识,具有综合应用性.同时,对高校实验室如何有效利用设备资源、开发拓展型实验有一定的示范作用.     

顺应论语境观与言语幽默的解读

言语幽默本质上是一种语言的使用现象,幽默效果的实现取决于语境.维索尔伦提出的顺应论语境观认为语言现象的理解必须顺应言语语境和交际语境,从而达到全面解读语言现象.顺应论语境观更强调从认知、心理和社会的角度全方位地理解语言的使用,因而对言语幽默具有更强的解释力.     

《电力电子技术》精品课程建设的研究与实践

精品课程建设是示范院校专业建设的主要内涵。电力电子技术是电气自动化技术专业的一门主要课程,通过对该院级精品课程的建设和实践,从硬件平台、教学方法、教学内容、考核评价、教学水平等方面进行了不断的探索和实践,总结提炼了一些本课程的特色和创新。     

光谱法研究Ni[S2P（OCH2CH2Ph）2]2与α,α＇-联吡啶加合反应

利用紫外光谱法研究了Ni[S2P（OCH2CH2Ph）2]2与α,α-联吡啶的加合反应。研究发现Ni[S2P（OCH2CH2Ph）2]2与α,α-联吡啶形成1∶1型加合物,在25℃的苯溶剂中,加合物的离解度α=0.07,稳定常数K稳^θ=2.1×10^6。