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排序方式: 共有919条查询结果,搜索用时 15 毫秒
901.
Mohammad Ahmadi Dr. Yaghoub Ahmadyousefi Zahra Salimi Dr. Rasoul Mirzaei Dr. Rezvan Najafi Dr. Bagher Amirheidari Dr. Fatemeh Rahbarizadeh Javad Kheshti Armin Safari Dr. Meysam Soleimani 《ChemMedChem》2023,18(3):e202200506
Active targeting using biological ligands has emerged as a novel strategy for the targeted delivery of diagnostic agents to tumor cells. Conjugating functional targeting moieties with diagnostic probes can increase their accumulation in tumor cells and tissues, enhancing signal detection and, thus, the sensitivity of diagnosis. Due to their small size, ease of chemical synthesis and site-specific modification, high tissue penetration, low immunogenicity, rapid blood clearance, low cost, and biosafety, peptides offer several advantages over antibodies and proteins in diagnostic applications. Epidermal growth factor receptor (EGFR) is one of the most promising cancer biomarkers for actively targeting diagnostic and therapeutic agents to tumor cells due to its active involvement and overexpression in various cancers. Several peptides for EGFR-targeting have been identified in the last decades, which have been obtained by multiple means including derivation from natural proteins, phage display screening, positional scanning synthetic combinatorial library, and in silico screening. Many studies have used these peptides as a targeting moiety for diagnosing different cancers in vitro, in vivo, and in clinical trials. This review summarizes the progress of EGFR-targeting peptide-based assays in the molecular diagnosis of cancer. 相似文献
902.
Behrooz Khatir Zahra Azimi Dijvejin Peter Serles Tobin Filleter Kevin Golovin 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(38):2301142
Droplet friction is common and significant in any field where liquids interact with solid surfaces. This study explores the molecular capping of surface-tethered, liquid-like polydimethylsiloxane (PDMS) brushes and its substantial effect on droplet friction and liquid repellency. By exchanging polymer chain terminal silanol groups for methyls using a single-step vapor phase reaction, the contact line relaxation time is decreased by three orders of magnitude–from seconds to milliseconds. This leads to a substantial reduction in the static and kinetic friction of both high- and low-surface tension fluids. Vertical droplet oscillatory imaging confirms the ultra-fast contact line dynamics of capped PDMS brushes, which is corroborated by live contact angle monitoring during fluid flow. This study proposes that truly omniphobic surfaces should not only have very small contact angle hysteresis, but their contact line relaxation time should be significantly shorter than the timescale of their useful application, i.e., a Deborah number less than unity. Capped PDMS brushes that meet these criteria demonstrate complete suppression of the coffee ring effect, excellent anti-fouling behavior, directional droplet transport, increased water harvesting performance, and transparency retention following the evaporation of non-Newtonian fluids. 相似文献
903.
This article addresses an interval observer-based control for stabilizing a class of nonlinear parameter-varying systems with noisy output by designing a switching surface. An input-dependent interval observer is firstly developed to estimate the lower and upper bounds of the states. Next, a switching-based controller is designed to stabilize the interval observer which implies the stability of the main parameter-varying system. The developed stabilizing switching surfaces are designed based on the outputs of the main system and the bounds of the states of the observer. By choosing an appropriate piecewise Lyapunov function, the closed-loop stability analysis of the interval observer system leads to a set of linear matrix inequalities including stability and Metzler constraints, simultaneously. The effectiveness of the proposed method is verified using the simulation results. 相似文献
904.
Zahra Karimi Shoar Hadi Pourpasha Saeed Zeinali Heris Seyed Borhan Mousavi Mousa Mohammadpourfard 《加拿大化工杂志》2023,101(10):5802-5817
At the city gate gas pressure reduction stations (CGSs), to prevent natural gas from forming a hydrate in the throttle valve, the natural gas is heated by the heater before reaching the pressure relief valve. Heat exchangers are an essential component of industrial processes that contribute significantly to total system energy. Since the element impacting heat exchanger performance is the fouling process, all fouling processes and models were dynamically simulated in this study. Through coding in the C++ language and simultaneous use of fluent functions, or, in other words, user-defined function (UDF), fouling-related models were defined for this software. The dynamic simulation was performed, and parameters such as fouling strength and layer thickness were calculated. The effects of changing operating conditions, such as gas inlet velocity, surface temperature, and fouling species concentration on fouling growth, were also evaluated. As the concentration of fouling species increased, the fouling rate also increased. The amount of supersaturation and fouling rate increased as the surface temperature increased. Due to the operational limitations of the system, to reduce the fouling rate, the gas inlet velocity should be as high as possible, and the fluid inlet temperature, surface temperature, and concentration of fouling species should be as low as possible. In this study, the required time to reach the efficiency of 70% of the heat exchanger was calculated using the modelling of this chamber, which was equivalent to 190 days. Additionally, the critical thickness of the fouling layer at this time was 3.5 cm. 相似文献
905.
Mortazavi Sayed Mohsen Najafi Sharif Rezasoltani Zahra Ghashang Majid Hami Zahra 《SILICON》2022,14(15):9695-9700
Silicon - The chemical composition of the insoles inbounded materials influences some of the mechanical properties of silicon insoles including; tensile strain and modules and moisture adsorption... 相似文献
906.
Zahra Shokri Baghi Nima Jafari Navimipour 《International Journal of Communication Systems》2023,36(8):e5458
Cloud computing has appeared as a technology allowing a company to employ computing resources such as applications, software, and hardware to calculate over the Internet. Scholars have paid great attention to cloud computing because of its cutting-edge availability, cost decrement, and boundless applications. A cloud database is a data storage site on the web where the optimal path is spotted to access the needed database. So, placing the ideal path to a database is crucial. The cloud database defined the scheduling problem to choose the perfect route. Cloud database path scheduling is a multifaceted procedure consisting of congestion control, routing list, and network flow distribution. It has a postponement in searching for the needed source route from the cloud database. Offering numerous infinite resources with the growing database workload is an NP-Hard optimization problem where the query request needs optimal schedules to respond to the required services. So, we have used a hybrid cuckoo search (CS) and genetic algorithm (GA), motivated by a social bird's phenomenon, to solve this problem. Integrating genetic operators has dramatically enhanced the balance between the capability of searching and utilization. 相似文献
907.
Khalaj-Amirhosseini Zahra Ashjari Mohsen Jamjah Roghieh Arabi Hassan Nazarabi Masoomeh 《Journal of Inorganic and Organometallic Polymers and Materials》2022,32(3):864-874
Journal of Inorganic and Organometallic Polymers and Materials - The modification of graphene oxide (GO) with octadecylamine was performed to emulsify dimethyl formamide droplets in octane via... 相似文献
908.
Muhammad Nadeem Ali Arshad Saman Riaz Syeda Wajiha Zahra Shahab S. Band Amir Mosavi 《计算机、材料和连续体(英文)》2023,74(2):2625-2640
Many organizations have insisted on protecting the cloud server from the outside, although the risks of attacking the cloud server are mostly from the inside. There are many algorithms designed to protect the cloud server from attacks that have been able to protect the cloud server attacks. Still, the attackers have designed even better mechanisms to break these security algorithms. Cloud cryptography is the best data protection algorithm that exchanges data between authentic users. In this article, one symmetric cryptography algorithm will be designed to secure cloud server data, used to send and receive cloud server data securely. A double encryption algorithm will be implemented to send data in a secure format. First, the XOR function will be applied to plain text, and then salt technique will be used. Finally, a reversing mechanism will be implemented on that data to provide more data security. To decrypt data, the cipher text will be reversed, salt will be removed, and XOR will be implemented. At the end of the paper, the proposed algorithm will be compared with other algorithms, and it will conclude how much better the existing algorithm is than other algorithms. 相似文献
909.
Vazifeh Zahra Mafakheri Fereshteh An Chunjiang 《Clean Technologies and Environmental Policy》2023,25(7):2185-2201
Clean Technologies and Environmental Policy - Biomass as an abundant renewable energy source can play a vital role in controlling the greenhouse gas emissions. The distributed nature of biomass and... 相似文献
910.
Saeed Abbasalizadeh Sahab Babaee Reza Kowsari-Esfahan Zahra Mazidi Yichao Shi Jake Wainer Joaquim M. S. Cabral Robert Langer Giovanni Traverso Hossein Baharvand 《Advanced functional materials》2023,33(49):2210233
“Organoid medicine” has rapidly progressed over the past decade as a new class of therapeutics with high functionality and complexity for addressing unmet medical needs such as effective treatment of patients suffering from chronic liver disease using liver organoids. Here, scalable and xeno-free integrated differentiation platforms are established to generate hepatic progenitors, mesenchymal stromal cells, and endothelial cells using individual human pluripotent stem cell lines as starting cell types for vascularized liver organoids generation. A scalable microfluidic system is developed to continuously generate cells-loaded microcapsules with self-biodegradable 4-arm-PEG-MMP1-sensitive peptide hydrogel as shell material, to support cells proliferation, self-condensation, and liver organoids generation through self-organization. Self-organized vascularized hepatobiliary organoids (VHOs) containing interconnected biliary networks and vascular structures are generated after optimizing the co-culture conditions inside hydrogel microcapsules and transferring the organoids to 3D dynamic suspension culture for further maturation. The VHOs show key functional features similar to the fetal and adult liver tissue including the expression of liver-specific marker genes, the ability to perform main liver metabolic functions, and inducing drug metabolism. The established platforms can be beneficial to the mass production of human liver organoids for liver organoid medicine and the development of safe, effective, and personalized drugs. 相似文献