Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway

Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role.     

An ANFIS-based approach for predicting the bed load for moderately sized rivers

A total of 346 sets of bed-load data obtained from the Kinta River, Pari River, Kerayong River and Langat River were analyzed using four common bed-load equations. These assessments, based on the median sediment size (d₅₀), show that the existing equations were unable to predict the measured bed load accurately. All existing equations over-predicted the measured values, and none of the existing bed-load equations gave satisfactory performance when tested on local river data. Therefore, the present study applies a new soft computing technique, i.e. an adaptive neuro-fuzzy inference system (ANFIS), to better predict measured bed-load data. Validation of the developed network (ANFIS) was performed using a new set of bed-load data collected at Kulim River. The results show that the recommended network can more accurately predict the measured bed-load data when compared to an equation based on a regression method.     

Prediction of sand mass and organic matter distribution via in situ measured wet sediment bulk density profile

The objective of the study is to develop a spatial prediction model of sand mass and organic matter distribution in an urban stormwater holding pond using in situ measured wet sediment bulk density profile data to spatially distinguish the most likely contaminated sediment deposit areas. The wet bulk density profiles of deposited sediment at 25 locations in the Berembang (Malaysia) stormwater holding pond were measured using a single-probe nuclear density gauge. The sand and organic matter compositions of the surface sediment sample, 5 cm thickness from the bed surface, were determined. Discriminant analysis (DA) was conducted to generate two Fisher’s linear discriminant functions for the prediction of sand mass and organic matter composition areas, respectively. The linear discriminant functions generated better area classifications of surface organic matter composition compared to the sand mass distribution using wet sediment bulk density data measured at more than 15 cm depth levels.     

A Comparative Study of the Mechanical Properties of Jute Fiber and Yarn Reinforced Concrete Composites

ABSTRACT

A relatively better performance of jute fiber and yarn reinforced concrete composites can open up a wide access to application of natural resources in concrete strengthening. In order to achieve this goal, an experimental investigation on the flexural, compressive and tensile strengths of Jute Fiber Reinforced Concrete Composites (JFRCC) and Jute Yarn Reinforced Concrete Composites (JYRCC) has been conducted. To draw a specific conclusion, the mix ratios of 1:1.5:3 and 1:2:4 (by volume) of concrete have been maintained with incorporation of jute fiber and yarn in concrete mortar having different cut lengths with distinct volumetric ratios. Finally, a comparison of the JFRCC and JYRCC strength increments with respect to the plain concrete has been investigated. A significant increment of compressive, flexural and tensile strength was observed only for a short cut length having a low volumetric ratio, where JYRCC increment value was always found progressive. A far more regular arrangement and adequate mixture of JYRCC was also visualized compare to JFRCC in concrete mortar. All the principal increment values were found only in case of JYRCC with a mix ratio of 1:1.5:3. So, it can be concluded that the presence of jute yarn and more cement content can strengthen the concrete to a great extent.     

Effect of sintering on the microstructure and mechanical properties of alloy titanium-wollastonite composite fabricated by powder injection moulding process

Composite biomaterials are in high demand in the medical field of today. The combination of bioactive wollastonite (WA) glass ceramic with the biocompatibility of alloy titanium (Ti6Al4V) could be a good candidate for implant applications. The rheological properties of Ti6Al4V/WA feedstock show a pseudoplastic behaviour with low activation energy. The feedstock was successfully injected as a green part with no defects. The green part was solvent debound for 6?h in heptane and thermal debound in an argon environment for 1?h. The brown part was successfully sintered at 1300?°C for 3?h with 5?°C/min heating and cooling rates. The average sintered density was 4.12?g/cm³; which is 97.5% from the theoretical density. The highest Young's modulus obtained was 18.10?GPa; which is in the range of human bone strength. EDX analysis shows that by increasing sintering temperature, the level of oxygen decreased. Cell viability test shown an absorbance increased with days increasing indicated that the cellular were proliferated on the composite Ti6Al4V/WA composite which also proved that the composite was non-toxic. This indicates that the Ti6Al4V/WA composite is suitable for bone implant applications.     

Evaluation of Polycyclic Aromatic Hydrocarbons Contamination in the Sediments of the Johor Strait,Peninsular Malaysia

In May 2013, sediment samples were collected from five stations in the Straits of Johor, near the southern tip of Peninsular Malaysia, in order to evaluate the distribution and sources of polycyclic aromatic hydrocarbons (PAHs). The concentrations of 16 United States Environmental Protection Agency PAHs varied from 650.5 to 1441.2 ng g ^?1 dry weight (dw) with a mean value of 985.5 ng g ^?1 dw. PAHs can be classified as moderate level pollution in the collected samples. When comparing PAHs in this study with that of the sediment quality guidelines (SQGs), it was found that the total PAHs, low molecular weight (LMW), and high molecular weight (HMW) PAHs might incur minimal adverse biological effects. The diagnostic ratios of individual PAHs indicated both petrogenic and pyrogenic origins with predominantly pyrogenic sources, the findings of which are further supported by the results from principal component analysis (PCA). The PCA results reveal contributions of 44.44%, 32.3%, and 18.96% for traffic-related, coal combustion, and petroleum-related products, respectively. These findings indicate that the effective monitoring and significant improvement resulting from the implementation of environmental regulations in Malaysia might have caused a shift in the source of petroleum hydrocarbons in the Straits of Johor's aquatic ecosystems from petrogenic to pyrogenic origins.     

Privacy issues in a psychiatric context: applying the ISD privacy framework to a psychiatric behavioural monitoring system

Privacy issues are frequently discussed amongst researchers, practitioners and patients in healthcare. However, psychiatric patients’ privacy issues get less attention in information system development (ISD), whereby they are one of the most important stakeholders. This paper applies Carew and Stapleton’s ISD privacy framework to psychiatric monitoring systems to understand the issues that are related to monitoring psychiatric patients’ behaviour. By understanding the privacy issues amongst patients, the research will be able to provide guidance to system developers to produce a privacy-sensitive system that can contribute to the system engineering for international stability. We will elaborate each factor in the framework (physical, social, psychological and informational) and then explain the relationship to the privacy of psychiatric patient.     

On business process monitoring using cross-flow coordination

This paper presents an approach for monitoring the execution progress of business processes. The monitoring focuses on the exceptions that could arise during this execution and, hence, could make the processes fail if not handled properly and timely. The approach relies on three flows known as control, communication, and navigation. The control flow connects tasks together with respect to a certain business logic. The communication flow captures the messages exchanged between persons/machines when they perform tasks of processes. Finally, the navigation flow captures the interactions between specialized networks that offer solutions to exceptions. These networks are built upon relations between tasks, between persons, and between machines. The coordination of control, communication, and navigation flows focuses on both the actions that are taken and the messages that are exchanged when handling exceptions. A system demonstrating flow development and coordination is, also, presented in the paper.