Decreased levels of a soluble form of the human adhesion receptor CD58 (LFA-3) in sera and synovial fluids of patients with rheumatoid arthritis

The mode of interaction between muramyl dipeptide (MDP), a compound with immunopharmacological activities, and 5-hydroxtryptamine (5-HT, serotonin) was studied in isolated nerve-smooth muscle preparations of the carp stomach. Application of exogenous 5-HT evoked direct smooth muscle contractions; electric neurogenic stimulation evoked twitches due to release of 5-HT from nerve endings. Contractions evoked by a high concentration of 5-HT (3-30 microM) were resistant to atropine and potentiated in the presence of MDP. Isamoltan (5-HTID antagonist) decreased the amplitude of contractions, whereas ketanserin (5-HT2 antagonist) and MDL 72,222 (5-HT3 antagonist) had no effect. The addition of low concentrations (0.1-1.5 microM) of 5-HT did not contract the preparation but caused a decrease in the amplitude of neurogenic twitches, which might be due to the presynaptic inhibition of serotonin release. This effect of 5-HT was not changed by isamoltan or ketanserin, but it was largely reduced in the presence of 5-HT3 antagonists tropisetron and MDL 72,222. This inhibitory effect of 5-HT on twitch amplitude was potentiated by MDP. The interaction of MDP with the serotonergic system thus involved not only potentiation of the postsynaptic effect of higher 5-HT concentrations, which might have been mediated via the 5-HT1 subsystem, but also presynaptic inhibition. MDP enhancement of 5-HT's inhibitory effect, mediated via 5-HT3 receptors, might represent a new feature in mutual 5-HT-MDP interactions.     

Über das Spreiten von Lipiden auf der Haut

On the Spreading of Lipids on the Skin The spontaneous spreading of liquid lipids on human skin is an important property for the use value of such products in cosmetic and pharmaceutical preparations. A comparative evaluation procedure based on an impression method is described, by means of which it is possible to determine the spreading rates in a reproducible manner. The standardized spreading values of a number of lipids are discussed in comparison with their chemical structure and physico-chemical data such as viscosity and surface tension. None of these data series correlates entirely with the spreading rates of all the lipids tested. However, it is possible to assess relative spreading rates within similarly structured groups of compounds.     

Esteralkohole — Herstellung,Eigenschaften, Reaktionen

Esteralcohols — Production, Properties, Reactions By equimolar reaction of long chain epoxides and aliphatic monocarbonic acids esteralcohols (2-hydroxyalkylester) are obtained, which represent a new oleophilic raw material group and base products for further syntheses. Conditions and limits of the ring opening reaction are investigated, which runs favouredly base catalyzed. From the subsequent reaction of the esteralcohols alcoholysis and catalytic hydrogenation, by which vicinal diols are of easy access, are explained in detail.     

The effect of coupling in a compact handset receiver

This paper deals with the performance of a compact dual diversity receiver. For this study we assume that the channel is characterized by a flat Rayleigh fading and that the incoming waves can be described by a Gaussian angular power distribution. The performance of a maximal-ratio-combiner in a correlated Rayleigh fading is given. These expressions are simplified and studied for the case of a dual diversity receiver. The influence of the mutual coupling between the sensors is taken into account using a simplified model. The results are compared with results obtained from realistic antenna simulations.     

Enhanced detectability of small objects in correlated clutter usingan improved 2-D adaptive lattice algorithm

Two-dimensional (2-D) adaptive filtering is a technique that can be applied to many image processing applications. This paper will focus on the development of an improved 2-D adaptive lattice algorithm (2-D AL) and its application to the removal of correlated clutter to enhance the detectability of small objects in images. The two improvements proposed here are increased flexibility in the calculation of the reflection coefficients and a 2-D method to update the correlations used in the 2-D AL algorithm. The 2-D AL algorithm is shown to predict correlated clutter in image data and the resulting filter is compared with an ideal Wiener-Hopf filter. The results of the clutter removal will be compared to previously published ones for a 2-D least mean square (LMS) algorithm. 2-D AL is better able to predict spatially varying clutter than the 2-D LMS algorithm, since it converges faster to new image properties. Examples of these improvements are shown for a spatially varying 2-D sinusoid in white noise and simulated clouds. The 2-D LMS and 2-D AL algorithms are also shown to enhance a mammogram image for the detection of small microcalcifications and stellate lesions.     

A simple gradient sign algorithm for transmit antenna weight adaptation with feedback

In this paper, a simple algorithm for adaptation of the complex baseband weights of a transmit antenna array using feedback from the receiver is proposed and analyzed. The system utilizes stochastic gradient adaptation to maximize the power delivered to the receiver for a constrained transmission power, which provides both fading diversity and beam steering gain. Dual perturbed transmission weight vectors are time multiplexed onto the pilot signal, and the receiver generates feedback selecting the perturbed weight vector which delivers greater power. This feedback is used to provide weight adaptation at the transmitter, and this adaptation is shown to be an update by a coarse estimate of the gradient of the delivered power. The performance of the algorithm is analyzed in terms of convergence and tracking of an AR1 fading channel, with simulations confirming the analysis. Bit error rate (BER) simulations in a dynamic fading channel show that the algorithm outperforms previously proposed vector selection feedback, and in slower fading, the algorithm substantially outperforms diversity space time coding.     

RDBM—A relational data base machine

After a short introduction to the field of data base machines the design of the RDBM (Relational Data Base Machine) is presented, which provides all the functions required of a relational data base system. Frequently used and time-consuming functions are supported by appropriate hardware components. A transaction-oriented multi-user system was designed which exploits the inherent parallelism of user tasks and data base functions.The RDBM consists of a quasi-associative mass store together with a system of special function processors with common access to a large main memory, and a general purpose mini-computer exercising overall control over all hardware components.