Non-MHC-restricted cell-mediated lysis of human oligodendrocytes in vitro: relation with CD56 expression

Oligodendrocytes and their myelin membranes are the apparent target of the autoimmune response that characterizes the human adult central nervous system-demyelinating disease multiple sclerosis. Human oligodendrocytes do not express MHC class II molecules, a requirement for MHC-restricted injury mediated by myelin-reactive CD4+ T cells, the cell type implicated in initiating the disease process. In this study we observed that human adult central nervous system-derived oligodendrocytes can be susceptible to non-MHC-restricted lysis mediated by myelin basic protein-reactive CD4+ T cell lines. Cytotoxicity was significantly greater (37 +/- 4 vs 7 +/- 3%) with cell lines in which a high proportion of cells (mean, 28 +/- 6%) expressed CD56 compared with cytotoxicity mediated by low CD56 cell lines (8 +/- 2%). High CD56 cell lines, when rested in IL-2, lost cytotoxic activity and had reduced expression of CD56 (mean, 5 +/- 2%). CD4+ T cells isolated from short term (3-day) anti-CD3/IL-2-activated mononuclear cell cultures did not express CD56 and were not cytotoxic to oligodendrocytes unless lectin was added. In contrast, an enriched population of non-T cells extracted from the same activated MNC cultures expressed CD56 as well as other NK cell-associated surface molecules and was cytotoxic. These results indicate the potential susceptibility of human oligodendrocytes to non-MHC-restricted injury mediated by both Ag-reactive and nonspecific cellular immune effector cells, with CD56 expression being a common feature of the effector cells.     

基于AT89S52和DS18B20的数字温度报警器的设计

以AT89S52单片机为控制核心设计了数字温度报警器,以数字温度传感器DS18B20为检测元件,配合LED数码管来实现对环境温度的实时监测,温度超过预设范围时产生报警信号。本文对系统硬件电路以及软件进行了设计,并对系统进行仿真测试,结果表明温度报警器操作简单,功能实用,有一定的实用价值。     

Intelligent traffic light under fog computing platform in data control of real-time traffic flow

As the global economy develops rapidly, traffic congestion has become a major problem for first-tier cities in various countries. In order to address the problem of failed real-time control of the traffic flow data by the traditional traffic light control as well as malicious attack and other security problems faced by the intelligent traffic light (ITL) control system, a multi-agent distributed ITL control method was proposed based on the fog computing platform and the Q learning algorithm used for the reinforcement learning in this study, and the simulation comparison was conducted by using the simulation platform jointly constructed based on the VISSIM-Excel VBA-MATLAB software. Subsequently, on the basis of puzzle difficulty of the computational Diffie–Helleman (CDH) and Hash Collision, the applicable security control scheme of ITL under the fog computing was proposed. The results reveal that the proposed intelligent control system prolongs the time of green light properly when the number of vehicles increases, thereby reducing the delay time and retention rate of vehicles; the security control scheme of ITL based on the puzzle of CDH is less efficient when the vehicle density increases, while that based on the puzzle of Hash collision is very friendly to the fog equipment. In conclusion, the proposed control method of ITL based on the fog computing and Q learning algorithm can alleviate the traffic congestion effectively, so the proposed method has high security.

     

AdaFuse: Adaptive Multiview Fusion for Accurate Human Pose Estimation in the Wild

International Journal of Computer Vision - Occlusion is probably the biggest challenge for human pose estimation in the wild. Typical solutions often rely on intrusive sensors such as IMUs to...     

结构化对等网络特性及关键技术分析

本文简述了对等网络的概念及分类,分析了结构化对等网络特性、存在问题和关键技术,指出结构化对等网络的发展前景。     

Fast full‐color reflective display via photoluminescent enhancement

Reflective displays are advantageous in applications requiring low power or daylight readability. However, there are no low‐cost reflective technologies capable of displaying bright colors. By employing photoluminescence to more efficiently use ambient light, we created a prototype display that provides bright, full color in a simple, low‐cost architecture. This prototype includes a novel electrokinetic shutter, a layer that incorporates patterned luminescent red, green, and blue sub‐pixel elements, and a novel optical out‐coupling scheme. The luminescent elements convert otherwise‐wasted portions of the incident spectrum to light in the desired color band, resulting in improved color saturation and lightness. This prototype provides a color gamut that is superior to competing reflective display technologies that utilize color filters in single‐layer side‐by‐side sub‐pixel architectures. The current prototype is capable of switching in <0.5 s; future displays based on an alternative electro‐optic shutter technology should achieve video rate operation. A transflective version of this technology has also been prototyped. The transflective version utilizes its backlight with a power efficiency that is at least three times that of a conventional liquid crystal display. These photoluminescence‐based technologies enable a host of applications ranging from low‐power mobile products and retail pricing signage to daylight readable signage for outdoor advertising segments.     

Output chattering attenuation between two tracking controllers

In this paper, an output chattering attenuation scheme is proposed for two tracking controllers. The controllers have integral actions and are used to eliminate the steady-state tracking errors. By designing a compensator and reducing the discontinuous switching, the output chattering at the switching points can be attenuated significantly. Moreover, combining with the generalized Kalman-Yakubovich-Popov (KYP) lemma and the parameter-dependent Lyapunov function method, this problem can be characterized in terms of linear matrix inequality (LMI) formulation. Finally, the simulation results demonstrate the effectiveness of the proposed method.     

Effect and Evolution of Oxide Film in the HDH-Ti Powder Surface on Densification Behavior During Sintering

Metallurgical and Materials Transactions A - In this work, we used hydride-dehydride Ti (HDH-Ti) powders (with the oxygen levels of 0.17 and 0.51 wt pct, respectively) combined with microstructural...     

地聚合物混凝土配比及力学性能研究

混凝土是巷道支护过程中的重要建筑材料,然而混凝土在巷道施工中常常出现质量问题,为了不影响正常生产,需要对其进行修补。地聚合物混凝土凝结时间快,早期强度高,界面结合能力强,耐高温性和抗冻性强,耐腐蚀性良好,具有用作修补材料的潜力。以粉煤灰和矿粉为原料,Na₂SiO₃溶液和NaOH为碱激发剂制备地聚合物胶砂,研究不同的碱激发剂模数（1.0、1.2、1.4）和掺量（10%、15%、20%）对不同龄期胶砂力学性能的影响。结果表明：当碱激发剂模数为1.2,碱掺量为15%时,胶砂强度达到最大值。设计正交试验,研究了不同水胶比（0.45、0.50、0.55）、粉煤灰掺量（30%、50%、70%）和砂率（30%、35%、40%）对不同龄期地聚合物混凝土的工作性能和力学性能的影响。结果表明：粉煤灰掺量对抗压强度影响最为显著,水胶比次之,而砂率对强度发展几乎没有影响。最优的配合比为水胶比为0.50,粉煤灰掺量为50%,砂率为35%。     

一种并行工程信息集成框架的构建

本文针对现有的并行工程信息集成框架对并行工程只提供消极支持的问题展开讨论，通过技术域，支撑域，管理域三个域的建立与分析，特别是对ＣＦ积极支持方法进行探讨，提出一种推拉式的建模思想，实现对并行设计的监督和控制。并依此思想建立了一个ＣＥ信息集成框架。